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1.
Singapore Med J ; 48(1): 34-40, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17245514

RESUMO

INTRODUCTION: Breast cancer is the commonest female cancer in Singapore. It is steadily rising with an incidence of 53.1 cases per 100,000 persons per year among women. Screening for detection of early lesions which are highly curable helps to reduce mortality. METHODS: Over three afternoon sessions in December 2003, 224 female patients aged 40-65 years, participated in interviews conducted by the National Healthcare Group Polyclinics, Singapore. The survey sought information on mammographic screening history, the time interval since the previous mammographic screening, and the reasons for not going for the screening. RESULTS: The survey found that only 26.4 percent (28 out of 106) among those aged 40 to 49 years had mammographic screening done within the past one year, and 43.2 percent (51 out of 118) among those aged 50 to 65 years had screening done within the last two years. Chinese women were twice more likely than Malay women to have a mammogram done. The commonest reasons for not wanting to have mammographic screening among women who did not have a mammogram done or had mammogram done more than two years ago, were lack of time (42.5 percent), fear of pain during the procedure (26.9 percent), and the belief that cancer would not happen to them (24.6 percent). CONCLUSION: Despite publicity on breast cancer being the commonest cancer among women in Singapore and cure being possible if the malignancy was detected early, close to half of the women aged 40-65 years old who attended the National Healthcare Group Polyclinics did not have mammographic screening done. One-quarter of the women who did not have mammogram screening did not do so as they did not think cancer would happen to them.


Assuntos
Assistência Ambulatorial/métodos , Neoplasias da Mama/diagnóstico por imagem , Mamografia , Programas de Rastreamento/métodos , Pacientes Ambulatoriais/estatística & dados numéricos , Vigilância da População , Adulto , Idoso , Neoplasias da Mama/epidemiologia , Feminino , Seguimentos , Humanos , Incidência , Malásia/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Singapura/epidemiologia
2.
Ann Acad Med Singap ; 35(1): 38-44, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16470273

RESUMO

INTRODUCTION: Severe rotavirus gastroenteritis in children causes significant morbidity worldwide and substantial deaths in developing countries. Hence, a live attenuated vaccine Rotarix was developed with human strain RIX4414 of G1P1A P[8] specificity. RIX4414 trials in infants have begun in developed and developing countries worldwide. An overview of RIX4414 in developed and developing countries and prospects with this vaccine in Asia are presented. METHODS: Completed RIX4414 trials have been reviewed. RESULTS: Two oral doses of RIX4414 were well tolerated with a reactogenicity profile similar to placebo. RIX4414 was also highly immunogenic, e.g., in a dose-ranging study conducted in Singapore, 98.8% to 100% of infants had a vaccine take after 2 doses. RIX4414 did not affect the immune response of simultaneously administered routine infant vaccines. RIX4414 significantly reduced severe rotavirus gastroenteritis in settings where multiple serotypes including the emerging G9 type co-circulated. CONCLUSION: These encouraging results warrant further evaluation of the vaccine worldwide and especially in developing countries with the highest need. Therefore, evaluation of the Rotarix vaccine is continuing in large phase III trials in Asia and worldwide.


Assuntos
Gastroenterite/prevenção & controle , Infecções por Rotavirus/prevenção & controle , Vacinas contra Rotavirus , Rotavirus/imunologia , Ásia , Pré-Escolar , Países em Desenvolvimento , Humanos , Lactente , Recém-Nascido , Rotavirus/classificação , Sorotipagem , Especificidade da Espécie , Vacinas Atenuadas
3.
Ann Acad Med Singap ; 33(5): 623-9, 2004 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15531959

RESUMO

INTRODUCTION: The study aimed to assess the effectiveness of massive SARS public education effort on SARS awareness and the conduct of those suspected of having SARS. MATERIALS AND METHODS: Five hundred and ninety-three respondents attending the National Healthcare Group Polyclinics (NHGP) participated in the survey from 9 to 13 June 2003. Associations between awareness of SARS symptoms and (i) first action to be taken and (ii) mode of transportation used, if the respondent was suspected of having SARS, were analysed using Chi-square or Fisher's exact tests. Logistic regression was performed to adjust for relevant covariates. RESULTS: The majority (92.7%) of the respondents were aware of SARS symptoms. Television (91.6%), newspaper (65.2%) and radio (30.4%) formed the top 3 sources of information on SARS. Slightly more than half (51.6%) of those who suspect themselves of having SARS would choose to visit their primary health care doctors, while 22.7% of the respondents would go to Tan Tock Seng Hospital (TTSH). If they suspected themselves to have SARS, most (84.9%) of the 578 respondents would react appropriately by taking the SARS ambulance or driving themselves to TTSH. However, 60 respondents would nonetheless take public transport to TTSH [by taxi 8.5%, mass rapid transit (MRT) or bus 1.9%]. In particular, the retired with lower educational levels were likely to be oblivious both to the symptoms of SARS and the possible consequences of travelling by inappropriate transport. CONCLUSION: Despite more than 2 months of intensive SARS public education in Singapore, there remain important gaps in knowledge and appropriate behaviour that have to be bridged.


Assuntos
Instituições de Assistência Ambulatorial/estatística & dados numéricos , Atitude Frente a Saúde , Controle de Doenças Transmissíveis , Síndrome Respiratória Aguda Grave/diagnóstico , Síndrome Respiratória Aguda Grave/terapia , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave/isolamento & purificação , Adolescente , Adulto , Distribuição por Idade , Idoso , Assistência Ambulatorial , Conscientização , Intervalos de Confiança , Surtos de Doenças/prevenção & controle , Feminino , Inquéritos Epidemiológicos , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Probabilidade , Medição de Risco , Estudos de Amostragem , Síndrome Respiratória Aguda Grave/epidemiologia , Distribuição por Sexo , Singapura/epidemiologia , Taxa de Sobrevida
4.
Singapore Med J ; 45(5): 199-213, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15143355

RESUMO

INTRODUCTION: The 2001 survey on primary medical care was undertaken to compare updated primary healthcare practices such as workload and working hours in the public and private sectors; determine private and public sector market shares in primary medical care provision; and gather the biographical profile and morbidity profile of patients seeking primary medical care from both sectors in Singapore. This is the third survey in its series, the earlier two having been carried out in 1988 and 1993, respectively. METHODS: The survey questionnaire was sent out to all the 1480 family doctors in private primary health outpatient practice, the 89 community-based paediatricians in the private sector who were registered with the Singapore Medical Council and also to all 152 family doctors working in the public sector primary medical care clinics. The latter comprised the polyclinics under the two health clusters in Singapore, namely the Singapore Health Services and National Healthcare Group, and to a very much smaller extent, the School Health Service's (SHS) outpatient clinics. The survey was conducted on 21 August 2001, and repeated on 25 September 2001 to enable those who had not responded to the original survey date to participate. Subjects consisted of all outpatients who sought treatment at the private family practice clinics (including the clinics of the community-based paediatricians), and the public sector primary medical care clinics, on the survey day. RESULTS: The response rate from the family doctors in private practice was 36 percent. Owing to the structured administrative organisation of the polyclinics and SHS outpatient clinics, all returns were completed and submitted to the respective headquarters. Response from the community-based paediatricians was poor, so their findings were omitted in the survey analysis. The survey showed that the average daily patient-load of a family doctor in private practice was 33 patients per day, which was lower than the 40 patients a day recorded in 1993. The average working hours of each of these private practitioners was 7.6 hours per day. Family doctors in public sector primary medical care clinics were responsible for 16.6 percent of the patient-load for primary medical care in Singapore while the remaining 83.4 percent was provided by family doctors in private practice. Singaporeans made approximately 4.4 visits to a family doctor in 2001, which was lower than the 5.0 visits ascertained in 1993. Chronic medical conditions seen by family doctors as a whole, increased from 29.2 percent in 1993 to 34.3 percent in 2001. Upper respiratory tract infections and hypertension were the two leading disease conditions seen at both private and public sector primary medical care clinics in 2001. The load of hypertension managed at primary medical care clinics had notably increased. CONCLUSION: The public sector share of outpatient load at 17 percent in 2001 is well within the 25 percent level set in the Government's 1993 White Paper on Affordable Healthcare. The private sector remains the main provider of primary medical care in Singapore, serving 83 percent of the population. The average workload for each family doctor in private practice had dropped from 40 to 33 patients a day between 1993 and 2001. There had been a notable growth in family doctors working in the private sector over this period. Both sectors saw an increase in the chronic disease load that they managed.


Assuntos
Pesquisas sobre Atenção à Saúde , Atenção Primária à Saúde/estatística & dados numéricos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Medicina de Família e Comunidade , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Pacientes/estatística & dados numéricos , Pediatria , Singapura
5.
Ann Acad Med Singap ; 32(1): 92-5, 2003 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-12625104

RESUMO

INTRODUCTION: It has been well established that proper treatment and management of human immunodeficiency virus (HIV)-infected mothers can decrease virus transmission to their fetuses. HIV screening of antenatal mothers attending government polyclinics was offered from 1998 at a subsidized cost of $5 and given on a voluntary basis. The polyclinics provide antenatal care to approximately 12% of pregnant mothers in Singapore who belong mainly to the lower socio-economic group. The uptake of the HIV screening by these mothers has been poor. MATERIALS AND METHODS: A one-month study was first undertaken in 1999 to determine the reasons for the poor uptake and to propose recommendations for improving the uptake. A second one-month study was undertaken in 2001 to evaluate the effect of the new strategies after implementation. FINDINGS: This first study showed that refusal for the test was mainly due to poor perception of risk among the mothers. The HIV screening test was incorporated into an antenatal screening package and consent was obtained for this package. This was implemented on an opt-out basis. The second study done after implementation showed that the uptake of the HIV screening improved from 45% to 99%. CONCLUSION: The incorporation of the antenatal HIV screening into an antenatal screening package, and implementing this on an opt-out basis, improves uptake to almost a universal level.


Assuntos
Infecções por HIV/diagnóstico , Serviços de Saúde Materna/estatística & dados numéricos , Complicações Infecciosas na Gravidez/diagnóstico , Diagnóstico Pré-Natal/estatística & dados numéricos , Atenção Primária à Saúde , Feminino , Humanos , Programas de Rastreamento , Gravidez , Singapura , Recusa do Paciente ao Tratamento
10.
Ann Acad Med Singap ; 31(4): 431-9, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12161877

RESUMO

INTRODUCTION: The Comprehensive Chronic Care Programme (CCCP) is an intensified programme designed to provide comprehensive care for the management of diabetes mellitus, hypertension and hyperlipidaemia at a primary healthcare setting. A formative study was done to evaluate the effectiveness of the CCCP compared to the normal polyclinic management of diabetes mellitus. MATERIALS AND METHODS: Control of diabetes (HbA1c) and hypertension (blood pressure) in 63 diabetic patients of a pilot CCCP was compared with 100 diabetic patients not on the programme (non-CCCP) after a 6-month follow-up. Paired t-tests were conducted for differences in mean HbA1c values between baseline and after 6 months. The H-rank test was applied to check for significant differences in change categories of hypertension control between CCCP and non-CCCP cases. RESULTS: In the CCCP group, there was a two-point decrease in HbA1c after 6 months and 65.1% of the patients showed improvement. The proportion of patients achieving optimal diabetic control increased from 9.5% to 36.5%. Conversely, there was deterioration in the non-CCCP group with decrease in the proportion of patients achieving optimal diabetic control from 31% to 21%. Of the hypertensive patients in the CCCP group, 54.5% showed an improvement in blood pressure (BP) control while 44% of the non-CCCP group showed improvement at 6 months. CONCLUSIONS: CCCP, a comprehensive chronic disease management programme, is effective for good diabetic control of patients with diabetes mellitus.


Assuntos
Assistência Integral à Saúde/organização & administração , Diabetes Mellitus/terapia , Gerenciamento Clínico , Hipertensão/terapia , Atenção Primária à Saúde/organização & administração , Avaliação de Programas e Projetos de Saúde , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Fatores de Tempo
11.
Ann Acad Med Singap ; 31(4): 474-8, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12161883

RESUMO

INTRODUCTION: Many developed and developing countries are grappling with recent epidemics of non-communicable diseases and how to effectively control them. Singapore as a small, compact and highly urbanized country has similarly experienced a rapid increase in its chronic disease load and has adopted a national approach to control them. METHODS: This paper traces the strategies taken in the 80s and the 90s to control non-communicable diseases and evaluates the effectiveness of the two approaches. RESULTS: In the 80s, the control programme was largely a Ministry of Health responsibility using a persuasive approach to reach out to the target groups. This produced some results through the lowering of hypertension and cholesterol. For the 90s, the approach was one of leadership by government working with relevant agencies to reach out to all relevant sectors in the population. This National Healthy Lifestyle Programme was given top political support. The integrated and comprehensive approach used showed some improvements in health and gave the direction where efforts should be channelled. CONCLUSION: The countrywide approach taken in Singapore for the control of non-communicable diseases illustrates a model where a national framework was adopted, harnessing health promotion and disease prevention and involving personal responsibility as a key success factor. This rides on a well-developed continuum of healthcare which aims to become an integrated and seamless one.


Assuntos
Controle de Doenças Transmissíveis/organização & administração , Programas Nacionais de Saúde/organização & administração , Doença Crônica , Comportamentos Relacionados com a Saúde , Humanos , Avaliação de Programas e Projetos de Saúde , Singapura , Fatores de Tempo
12.
Ann Acad Med Singap ; 31(4): 479-86, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12161884

RESUMO

INTRODUCTION AND METHODS: Cardiovascular diseases have progressively increased in importance as a major contributor of morbidity and mortality in Asia. However, many countries in Asia do not have nationwide systematically-collected and standardised data on myocardial infarction (MI). To accurately document the extent of atherosclerotic coronary heart disease in Singapore, a nationwide myocardial infarct registry was established in the mid-1986. Possible myocardial infarct events were identified through daily national lists of cardiac enzymes, hospital discharge codes, mortuary records and the national death registry. Data obtained from clinical history, cardiac enzymes and 12-lead electrocardiogram Minnesota codes were entered into an algorithm based on the WHO MONICA study. Cases identified as "definite" MI were included in the decade's review for this study. RESULTS: From 1988 to 1997, 13,048 myocardial infarct events were diagnosed with 3367 deaths. There was a 39.1% decline in mortality, with an average decline of 6.5% per year [95% confidence intervals (CI), -3.9% to -9.1%]. However, the decline in incidence was only 20.8% with an average decline of 2.4% per year (95% CI, -6.6% to -1.2%). The highest incidence and mortality rates for both genders were seen in the Indians, followed by the Malays and the Chinese. CONCLUSION: Over 10 years, from 1988 to 1997, we documented a significant fall in mortality from MI in Singapore. There was a smaller decline in the incidence of infarction. Singapore implemented a National Healthy Lifestyle Programme in 1992 as a 10-year effort. The disparity in the incidence and mortality may suggest that a more dramatic and immediate impact has taken place in mortality through therapeutic programmes; primary preventive programmes would be more difficult to evaluate and have a more gradual impact. Only with continual accurate data collection through the whole country, over a much longer period, can the relative value of preventive and therapeutic programmes in coronary heart disease be assessed.


Assuntos
Etnicidade/estatística & dados numéricos , Infarto do Miocárdio/etnologia , Infarto do Miocárdio/epidemiologia , Sistema de Registros/estatística & dados numéricos , Adulto , Distribuição por Idade , China/etnologia , Comparação Transcultural , Feminino , Humanos , Incidência , Índia/etnologia , Malásia/etnologia , Masculino , Pessoa de Meia-Idade , Distribuição por Sexo , Singapura/epidemiologia , Fatores de Tempo
13.
Atherosclerosis ; 155(1): 179-86, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11223440

RESUMO

AIMS: To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS: Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non-diabetics, 179 newly diagnosed diabetics and 150 known diabetics. Amongst the diabetics, there were 185 Chinese, 66 Malays and 78 Asian Indians. Diagnosis of diabetes mellitus (DM) was based on the 2 h glucose alone, after a 75 g oral glucose tolerance test. Blood pressure (BP), lipid profile, glucose, insulin and anthropometric indices were obtained from all subjects. RESULTS: Subjects with diabetes (new and known) exhibited significantly higher triglyceride (TG), lower high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL)/apolipoprotein B (apo B) ratio (LDL size) compared with normoglycaemic subjects. They were more obese (generalised and central) and had higher systolic and diastolic BP. There was no difference in lipid risk factors between the two groups with diabetes although those with new diabetes were more obese whilst those with known diabetes had higher fasting glucose. Amongst subjects with diabetes, there were no significant differences between ethnic groups in TG, HDL-C, LDL/apo B ratio, or waist to hip ratio (WHR). Female Malays with diabetes had higher total cholesterol and were more obese whilst male Asian Indians with diabetes had higher fasting insulin. CONCLUSION: Asian Indians had lower HDL-C and LDL/apo B ratio than Chinese or Malays amongst normoglycaemic subjects. However, these differences between ethnic groups were not seen in subjects with DM.


Assuntos
Doenças Cardiovasculares/etnologia , Diabetes Mellitus/etnologia , Adolescente , Adulto , Idoso , Glicemia/análise , Índice de Massa Corporal , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/etiologia , China/etnologia , Coleta de Dados , Complicações do Diabetes , Diabetes Mellitus/sangue , Feminino , Humanos , Índia/etnologia , Insulina/sangue , Lipídeos/sangue , Malásia/etnologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Singapura
14.
Singapore Med J ; 41(6): 271-8, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-11109343

RESUMO

AIM OF THE STUDY: To evaluate the feasibility of an improved visual acuity screening program for Singapore 4-year-old preschool children and to draw up an appropriate referral criteria as well as evaluating the rates and outcomes of these referrals. METHOD: A total of 450 children aged 4 to 4 1/2 years, who attended 3 polyclinics of the Family Health Service (FHS) for their 4-year-old Developmental Health Screening during the study period from 1/4/1997 to 30/6/1997 were recruited for the study. Children who were tested with Snellen (or Sloan) visual acuity chart resulting in visual acuity of 6/9 or worse, or failed to pass the 3 mm medium plate at 30 cm distance (300 seconds of arc) in the Frisby Stereotest, or were found to have strabismus, or were untestable in either visual acuity test or stereotest were offered referral to ophthalmologists in the hospitals for specialist assessment. RESULT: 82.7% of the 450 children were successfully screened with Snellen (or Sloan) chart while 91.6% were successfully screened with Frisby Stereotest. In all, 180 children were evaluated by ophthalmologists. Majority of the children were referred because of their abnormal visual acuity test while only 2 children were referred for failing stereotest alone. Among the 180 children referred, 63 (35.0%) were found to have refractive errors for which spectacles were prescribed. Eight children had amblyopia and 2 children had strabismus which were not detected at the polyclinic screening. The untestable children evaluated had significantly higher abnormality rate (37.5%) than that of children who had 6/9 vision (8.8%) therefore they should be offered referral for further evaluation. There was high "refused referral" rate of 39.0%. Parents of children who were untestable or had 6/9 vision were found to be more likely to refuse offer of referral. If these two groups of children were excluded, the "refused referral" rate dropped to 13.3%. When the referral criteria for visual acuity was reset at 6/12 instead of 6/9, the referral rate dropped from 39.6% to a more manageable 26.7% and the positive predictive value improved from 35.4% to 48.3% and none of the children with amblyopia were missed being screened-out. CONCLUSION: The study confirmed the feasibility of doing visual acuity screening at 4 to 41/2 year-old. The referral criteria for abnormal visual acuity should be set at 6/12. The efficacy of adding Frisby stereotest needs further evaluation.


Assuntos
Serviços de Saúde da Criança/organização & administração , Transtornos da Visão/diagnóstico , Seleção Visual/organização & administração , Acuidade Visual , Fatores Etários , Viés , Pré-Escolar , Estudos de Viabilidade , Humanos , Avaliação de Resultados em Cuidados de Saúde , Encaminhamento e Consulta/estatística & dados numéricos , Singapura , Fatores de Tempo , Transtornos da Visão/terapia
15.
J Clin Endocrinol Metab ; 85(8): 2854-9, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10946893

RESUMO

Recent studies using the ratio of plasma aldosterone concentration (PAC) to PRA as the screening test for primary aldosteronism in hypertensive populations suggested that the prevalence may be as high as 5-15%, with well over half of the subjects having normal serum potassium concentrations. Despite an increasing clinical awareness of this entity, many clinicians are reluctant to consider routine screening for primary aldosteronism in essential hypertensive patients because there are few community-based prevalence studies of primary aldosteronism in different populations. Furthermore, genetic and environmental differences may affect the prevalence and presentation of primary aldosteronism in distinct populations. This study was designed to determine the prevalence of primary aldosteronism in the predominantly Chinese population in Singapore. Three hundred and fifty unselected adult hypertensive patients attending two primary care clinics had random ambulatory measurements for PAC (nanograms per dL) and PRA (nanograms per mL/h). Serum urea, creatinine, and electrolyte measurements were obtained simultaneously. Subjects with renal insufficiency (serum creatinine, >140 micromol/L) and those treated with glucocorticoids or spironolactone were excluded. Screening was considered positive if the PAC: PRA ratio was more than 20 and the PAC was more than 15 ng/dL (>416 pmol/L). Primary aldosteronism was confirmed with the determination of PAC after 2 L saline administered iv over 4 h. Adrenal computed tomographic (CT) scans were performed in biochemically confirmed cases of primary aldosteronism. Further localization with adrenal vein sampling was carried out in selected patients with equivocal findings on adrenal CT scan. Sixty-three (18%) of the 350 hypertensive patients (215 women and 135 men; age range, 23-75 yr) were screened positive for primary aldosteronism. Only 13 of these 63 subjects (21%) were hypokalemic (serum potassium, <3.5 mmol/L). Confirmatory studies were carried out in 56 (89%) of the subjects with a positive PAC:PRA ratio. Using a PAC above 10 ng/dL (>277 pmol/L) after saline infusion as the diagnostic cut-off, 16 of the 56 patients had biochemically confirmed primary aldosteronism. Hypokalemia was found in 6 of the 16 patients (37.5%) with primary aldosteronism. Subtype evaluation with adrenal CT scan and adrenal vein sampling indicated that half of the patients with primary aldosteronism may have had potentially curable unilateral adrenal adenoma. Our data suggest that primary aldosteronism occurs in at least 5% of the adult Asian hypertensive population, and approximately half of these individuals may have potentially curable, unilateral, aldosterone-producing adrenal adenoma. Our findings also confirm the poor predictive value of hypokalemia in both the diagnosis and the exclusion of primary aldosteronism.


Assuntos
Hiperaldosteronismo/complicações , Hiperaldosteronismo/epidemiologia , Hipertensão/complicações , Adulto , Idoso , Aldosterona/sangue , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , China/etnologia , Feminino , Humanos , Hiperaldosteronismo/diagnóstico , Hipertensão/sangue , Hipertensão/epidemiologia , Índia/etnologia , Malásia/etnologia , Masculino , Pessoa de Meia-Idade , Potássio/sangue , Prevalência , Renina/sangue , Singapura/epidemiologia
16.
Respirology ; 5(2): 175-82, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10894108

RESUMO

OBJECTIVE: From late July to the beginning of October 1997, countries of Southeast Asia experienced severe smoke haze pollution from uncontrolled forest fires mainly in the Indonesian states of Kalimantan and Sumatra. In Singapore, the impact of the 1997 haze was felt in the period from the end of August to the first week of November 1997 as a result of prevailing winds. METHODOLOGY: The Ministry of the Environment monitors ambient air quality by a country-wide telemetric air quality monitoring and management network, with 15 stations located throughout the island, linked via a public telephone network to a central control station at the Environment Building. The monitoring methods used are the United States Environmental Protection Agency (USEPA) reference methods. The Pollutant Standards Index (PSI) developed by the USEPA is used for the reporting of daily air pollution concentrations. Intervals on the PSI scale are related to the potential health effects of the daily measured concentrations of the five major air pollutants: sulfur dioxide, particulate matter (PM10), nitrogen dioxide, ozone and carbon monoxide. Public sector health facilities which come under the Ministry of Health, have computerized patient care systems which enable the routine ongoing surveillance of disease conditions for the period of the haze. Attention during the period of the haze was focused on conditions related to health effects of the haze. Data sources for the monitoring of the lung health effects of the haze included morbidity from public sector outpatient care facilities, accidents and emergency departments, public sector inpatient care facilities and national mortality data. RESULTS: Findings from the health impact of the haze showed that there was a 30% increase in outpatient attendance for haze-related conditions. An increase in PM10 levels from 50 microg/m3 to 150 microg/m3 was significantly associated with increases of 12% of upper respiratory tract illness, 19% asthma and 26% rhinitis. Supplementary findings from scanning the electron microscopic sizing of the haze particles showed that 94% of the particles in the haze were below 2.5 microm in diameter. This was consistent with emissions from combustion sources originating over 500 km from Singapore. This has been of some concern because particles smaller than 2.5 microm in diameter can easily bypass normal body defence metabolism and penetrate deeply into the alveoli of the lungs. During the same period, there was also an increase in accident and emergency attendance for haze-related conditions. There was no significant increase in hospital admissions or in mortality. CONCLUSION: The present study found that the health effects from the 1997 smoke haze in Singapore were generally mild.


Assuntos
Poluentes Atmosféricos/efeitos adversos , Poluentes Atmosféricos/análise , Incêndios , Doenças Respiratórias/epidemiologia , Doenças Respiratórias/etiologia , Monóxido de Carbono/efeitos adversos , Monóxido de Carbono/análise , Conjuntivite/epidemiologia , Conjuntivite/etiologia , Dermatite/epidemiologia , Dermatite/etiologia , Humanos , Dióxido de Nitrogênio/efeitos adversos , Dióxido de Nitrogênio/análise , Ozônio/efeitos adversos , Ozônio/análise , Doenças Respiratórias/mortalidade , Singapura/epidemiologia , Fumaça/efeitos adversos , Dióxido de Enxofre/efeitos adversos , Dióxido de Enxofre/análise , Árvores
17.
Diabetes ; 48(5): 1088-92, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-10331414

RESUMO

Individuals with isolated low HDL cholesterol are at increased risk of coronary artery disease. It has been reported previously that this is an insulin-resistant state. We analyzed data from the 1992 Singapore National Health Survey with the objective of defining the clinical and metabolic parameters associated with isolated low HDL cholesterol. A total of 3,568 individuals were selected by stratified random sampling. Subjects with low HDL cholesterol (<0.9 mmol/l) and "ideal" total cholesterol (<5.2 mmol/l) were identified. Data on anthropometry, blood pressure (BP), insulin resistance, glucose tolerance, sex, smoking habit, and ethnic group were examined. We found that this group was heterogeneous. Those with fasting triglyceride (TG) >1.7 mmol/l (low HDL/high TG) displayed features of the insulin resistance syndrome characterized by obesity, higher diastolic BP, greater insulin resistance, and a greater tendency to have diabetes or impaired glucose tolerance (IGT). If fasting TG was <1.7 mmol/l (isolated low HDL cholesterol), individuals were similar to the general population in terms of insulin resistance and obesity. Both groups were more commonly men and Asian Indian. The ethnic difference in prevalence could not be explained by differences in diet, exercise, alcohol ingestion, or smoking. Our data support the view that Asian Indians are genetically predisposed to isolated low HDL cholesterol as well as the insulin resistance syndrome. The higher prevalence of isolated low HDL cholesterol, the young age at which individuals exhibit this phenotype (mean age 32.5 years), along with the greater propensity for Asian Indians to develop insulin resistance and IGT contribute to the threefold increased incidence of myocardial infarction in those <65 years of age in this ethnic group.


Assuntos
HDL-Colesterol/deficiência , Jejum , Hipertrigliceridemia/complicações , Resistência à Insulina , Adolescente , Adulto , Idoso , Pressão Sanguínea , Diástole , Humanos , Índia/etnologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/fisiopatologia
18.
Diabetes Care ; 22(2): 241-7, 1999 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10333940

RESUMO

OBJECTIVE: The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS: A combination of disproportionate stratified sampling and systematic sampling were used to select the sample for the survey. The final number of respondents was 3,568, giving a response rate of 72.6%. All subjects fasted for 10 h and were given a 75-g glucose load, except those known to have diabetes. Blood was taken before and 2 h after the glucose load. Diagnosis of diabetes was based on 2-h glucose alone. RESULTS: The age-standardized prevalence of diabetes in Singapore residents aged 18-69 years was 8.4%, with more than half (58.5%) previously undiagnosed. Prevalence of diabetes was high across all three ethnic groups. The prevalence of impaired glucose tolerance was 16.1%, that of hypertension was 6.5%, and 19.0% were regular smokers. The total cholesterol (mean +/- SD) of nondiabetic Singaporeans was 5.18 +/- 1.02 mmol/l; 47.9% had cholesterol > 5.2 mmol/l, while 15.4% had levels > 6.3 mmol/l. Mean LDL cholesterol was 3.31 +/- 0.89 mmol/l; HDL cholesterol was 1.30 +/- 0.32 mmol/l, and triglyceride was 1.23 +/- 0.82 mmol/l. CONCLUSIONS: Prevalence of diabetes was high across all three ethnic groups. Ethnic differences in prevalence of diabetes, insulin resistance, central obesity, hypertension, smoking, and lipid profile could explain the differential coronary heart disease rates in the three major ethnic groups in Singapore.


Assuntos
Doenças Cardiovasculares/epidemiologia , Diabetes Mellitus/epidemiologia , Angiopatias Diabéticas/epidemiologia , Etnicidade/estatística & dados numéricos , Inquéritos Epidemiológicos , Adolescente , Adulto , Fatores Etários , Idoso , Constituição Corporal , Índice de Massa Corporal , China/etnologia , Colesterol/sangue , Complicações do Diabetes , Feminino , Humanos , Índia/etnologia , Resistência à Insulina , Malásia/etnologia , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Fatores Sexuais , Singapura/epidemiologia , Triglicerídeos/sangue
19.
Ann Acad Med Singap ; 27(2): 154-60, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9663301

RESUMO

Mammographic screening for breast cancer has been shown to be an effective tool for reducing mortality from the disease in many studies in the West, if high technical quality and acceptance by the target population are achieved. The objective of the Singapore Breast Screening Project was to determine if the same results could be obtained among local women by inviting a random sample of 69,500 women aged 50 to 64 years for a screening mammogram over two years. To date, the compliance rate among the women invited has been 41.7%. The objective of the present substudy was to determine participants' views on the accessibility and acceptability of organised mammographic screening. Of the three hundred women interviewed, 85% were satisfied with the information given prior to the visit, while 67% needed to change the original appointment given. The majority were satisfied with aspects of the visit such as waiting time, privacy and explanation given during the test. However, 35.1% reported at least moderate discomfort during mammography. A substantial proportion (39.7%) of attenders felt that there was very little hope of cure even if cancer was detected early. When asked the most important reason for attending, most indicated they had taken the opportunity for a free check-up to be assured they were well. Almost all (95.7%) reported a willingness to be screened again, but most would not be willing to pay for a mammogram at the current rates.


Assuntos
Atitude Frente a Saúde , Neoplasias da Mama/prevenção & controle , Mamografia , Programas de Rastreamento , Agendamento de Consultas , Neoplasias da Mama/diagnóstico por imagem , Feminino , Financiamento Pessoal , Acessibilidade aos Serviços de Saúde , Humanos , Mamografia/normas , Programas de Rastreamento/economia , Pessoa de Meia-Idade , Aceitação pelo Paciente de Cuidados de Saúde , Educação de Pacientes como Assunto , Satisfação do Paciente , Relações Médico-Paciente , Vigilância da População , Privacidade , Prognóstico , Tecnologia Radiológica/normas , Fatores de Tempo
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