The association between the social adaptive skills of school-aged children with congenital heart disease and mothers' decision factors for providing disease explanations in Japan: a cross-sectional study.

PURPOSE: This study aimed to clarify the factors related to mothers' decisions to provide disease explanations to their children, investigate the associations between those factors and social adaptive skills, and examine support relative to children's growth and development. METHODS: Data were collected from anonymous, self-administered questionnaires answered by 71 mothers of outpatient school-aged children with congenital heart disease. The questionnaire items included characteristics of mothers and children, decision factors for providing disease explanations, and children's social adaptive skills (Asahide-Shiki social adaptive skills test). Factor analysis was performed on the decision factors, and multiple regression analysis was performed to examine the association between the identified factors and each social adaptive skill. RESULTS: The decision factors for providing disease explanations were the mother's explanation ability, the receptive capability of the child, and the child's interest and literacy regarding the explanation. Multiple regression analysis showed that language and social life skills were significantly associated with the child's receptive capability, and language and daily life skills were significantly associated with the child's interest and literacy regarding the explanation. CONCLUSION: Improving children's language, social life, and daily life skills may enhance their receptive capability and literacy regarding explanations of their disease.

Clinical course of drug-induced collagenous colitis and histological changes after drug withdrawal in a Japanese case series.

Although the incidence of drug-induced collagenous colitis has been increasing, details of its clinical course and histological changes after withdrawal of the suspected causative drugs remain unclear. To shed light on this issue, we studied 15 patients with collagenous colitis diagnosed between 1999 and 2011 in our hospital. Clinical cure was achieved in 14 patients after withdrawal of the suspected causative drugs and in one patient after the administration of prednisolone. Six patients underwent a second colorectal endoscopic examination after clinical cure, and the histological features were compared with those in patients during the clinically active phase. Four of these six patients showed disappearance of the collagen band and a decrease in inflammatory cells, but the collagen band remained in the other two despite a decrease in inflammatory cells. Cell proliferation as shown by Ki-67 immunostaining was restored to normal, irrespective of whether the collagen band was retained. The surface-absorptive epithelia became mature in all patients. Histological improvement in collagenous colitis is believed to involve normalization of cell proliferation and maturation of the absorptive epithelium, and not necessarily disappearance of the collagen band.