RESUMO
Selective serotonin reuptake inhibitors (SSRIs) are usually well tolerated in the pediatric population, and widely used in the treatment of obsessive-compulsive disorder (OCD). Of the 51 pediatric patients with obsessive-compulsive disorder seen in our outpatient clinic between January 2009 and July 2009, 3 of them developed behavioral disinhibition after treatment with fluvoxamine. These cases are described and discussed in relation to the use of CYP2D6 and CYP2C19 pharmacogenetic testing in patients treated with serotonin-selective reuptake inhibitors.
Assuntos
Fluvoxamina/efeitos adversos , Comportamento Impulsivo/induzido quimicamente , Inibidores Seletivos de Recaptação de Serotonina/efeitos adversos , Hidrocarboneto de Aril Hidroxilases/metabolismo , Criança , Citocromo P-450 CYP2C19 , Citocromo P-450 CYP2D6/metabolismo , Fluvoxamina/uso terapêutico , Humanos , Inibição Psicológica , Masculino , Transtorno Obsessivo-Compulsivo/tratamento farmacológico , Farmacogenética , Inibidores Seletivos de Recaptação de Serotonina/uso terapêuticoRESUMO
Does the magical number four characterize our visual working memory (VWM) capacity for all kinds of objects, or is the capacity of VWM inversely related to the perceptual complexity of those objects? To find out how perceptual complexity affects VWM, we used a change detection task to measure VWM capacity for six types of stimuli of different complexity: colors, letters, polygons, squiggles, cubes, and faces. We found that the estimated capacity decreased for more complex stimuli, suggesting that perceptual complexity was an important factor in determining VWM capacity. However, the considerable correlation between perceptual complexity and VWM capacity declined significantly if subjects were allowed to view the sample memory display longer. We conclude that when encoding limitations are minimized, perceptual complexity affects, but does not determine, VWM capacity.
