Myotonia congenita-associated mutations in chloride channel-1 affect zebrafish body wave swimming kinematics.

Myotonia congenita is a human muscle disorder caused by mutations in CLCN1, which encodes human chloride channel 1 (CLCN1). Zebrafish is becoming an increasingly useful model for human diseases, including muscle disorders. In this study, we generated transgenic zebrafish expressing, under the control of a muscle specific promoter, human CLCN1 carrying mutations that have been identified in human patients suffering from myotonia congenita. We developed video analytic tools that are able to provide precise quantitative measurements of movement abnormalities in order to analyse the effect of these CLCN1 mutations on adult transgenic zebrafish swimming. Two new parameters for body-wave kinematics of swimming reveal changes in body curvature and tail offset in transgenic zebrafish expressing the disease-associated CLCN1 mutants, presumably due to their effect on muscle function. The capability of the developed video analytic tool to distinguish wild-type from transgenic zebrafish could provide a useful asset to screen for compounds that reverse the disease phenotype, and may be applicable to other movement disorders besides myotonia congenita.

LBP-based edge-texture features for object recognition.

This paper proposes two sets of novel edge-texture features, Discriminative Robust Local Binary Pattern (DRLBP) and Ternary Pattern (DRLTP), for object recognition. By investigating the limitations of Local Binary Pattern (LBP), Local Ternary Pattern (LTP) and Robust LBP (RLBP), DRLBP and DRLTP are proposed as new features. They solve the problem of discrimination between a bright object against a dark background and vice-versa inherent in LBP and LTP. DRLBP also resolves the problem of RLBP whereby LBP codes and their complements in the same block are mapped to the same code. Furthermore, the proposed features retain contrast information necessary for proper representation of object contours that LBP, LTP, and RLBP discard. Our proposed features are tested on seven challenging data sets: INRIA Human, Caltech Pedestrian, UIUC Car, Caltech 101, Caltech 256, Brodatz, and KTH-TIPS2-a. Results demonstrate that the proposed features outperform the compared approaches on most data sets.

Human detection by quadratic classification on subspace of extended histogram of gradients.

This paper proposes a quadratic classification approach on the subspace of Extended Histogram of Gradients (ExHoG) for human detection. By investigating the limitations of Histogram of Gradients (HG) and Histogram of Oriented Gradients (HOG), ExHoG is proposed as a new feature for human detection. ExHoG alleviates the problem of discrimination between a dark object against a bright background and vice versa inherent in HG. It also resolves an issue of HOG whereby gradients of opposite directions in the same cell are mapped into the same histogram bin. We reduce the dimensionality of ExHoG using Asymmetric Principal Component Analysis (APCA) for improved quadratic classification. APCA also addresses the asymmetry issue in training sets of human detection where there are much fewer human samples than non-human samples. Our proposed approach is tested on three established benchmarking data sets--INRIA, Caltech, and Daimler--using a modified Minimum Mahalanobis distance classifier. Results indicate that the proposed approach outperforms current state-of-the-art human detection methods.

Laplacian eigenmap with temporal constraints for local abnormality detection in crowded scenes.

This paper addresses the problem of detecting and localizing abnormal activities in crowded scenes. A spatiotemporal Laplacian eigenmap method is proposed to extract different crowd activities from videos. This is achieved by learning the spatial and temporal variations of local motions in an embedded space. We employ representatives of different activities to construct the model which characterizes the regular behavior of a crowd. This model of regular crowd behavior allows the detection of abnormal crowd activities both in local and global contexts and the localization of regions which show abnormal behavior. Experiments on the recently published data sets show that the proposed method achieves comparable results with the state-of-the-art methods without sacrificing computational simplicity.

Quantifying limb movements in epileptic seizures through color-based video analysis.

This paper proposes a color-based video analytic system for quantifying limb movements in epileptic seizure monitoring. The system utilizes colored pyjamas to facilitate limb segmentation and tracking. Thus, it is unobtrusive and requires no sensor/marker attached to patient's body. We employ Gaussian mixture models in background/foreground modeling and detect limbs through a coarse-to-fine paradigm with graph-cut-based segmentation. Next, we estimate limb parameters with domain knowledge guidance and extract displacement and oscillation features from movement trajectories for seizure detection/analysis. We report studies on sequences captured in an epilepsy monitoring unit. Experimental evaluations show that the proposed system has achieved comparable performance to EEG-based systems in detecting motor seizures.

Non-intrusive head movement analysis of videotaped seizures of epileptic origin.

In this work we propose a non-intrusive video analytic system for patient's body parts movement analysis in Epilepsy Monitoring Unit. The system utilizes skin color modeling, head/face pose template matching and face detection to analyze and quantify the head movements. Epileptic patients' heads are analyzed holistically to infer seizure and normal random movements. The patient does not require to wear any special clothing, markers or sensors, hence it is totally non-intrusive. The user initializes the person-specific skin color and selects few face/head poses in the initial few frames. The system then tracks the head/face and extracts spatio-temporal features. Support vector machines are then used on these features to classify seizure-like movements from normal random movements. Experiments are performed on numerous long hour video sequences captured in an Epilepsy Monitoring Unit at a local hospital. The results demonstrate the feasibility of the proposed system in pediatric epilepsy monitoring and seizure detection.

Markerless video analysis for movement quantification in pediatric epilepsy monitoring.

This paper proposes a markerless video analytic system for quantifying body part movements in pediatric epilepsy monitoring. The system utilizes colored pajamas worn by a patient in bed to extract body part movement trajectories, from which various features can be obtained for seizure detection and analysis. Hence, it is non-intrusive and it requires no sensor/marker to be attached to the patient's body. It takes raw video sequences as input and a simple user-initialization indicates the body parts to be examined. In background/foreground modeling, Gaussian mixture models are employed in conjunction with HSV-based modeling. Body part detection follows a coarse-to-fine paradigm with graph-cut-based segmentation. Finally, body part parameters are estimated with domain knowledge guidance. Experimental studies are reported on sequences captured in an Epilepsy Monitoring Unit at a local hospital. The results demonstrate the feasibility of the proposed system in pediatric epilepsy monitoring and seizure detection.

Regularized common spatial pattern with aggregation for EEG classification in small-sample setting.

Common spatial pattern (CSP) is a popular algorithm for classifying electroencephalogram (EEG) signals in the context of brain-computer interfaces (BCIs). This paper presents a regularization and aggregation technique for CSP in a small-sample setting (SSS). Conventional CSP is based on a sample-based covariance-matrix estimation. Hence, its performance in EEG classification deteriorates if the number of training samples is small. To address this concern, a regularized CSP (R-CSP) algorithm is proposed, where the covariance-matrix estimation is regularized by two parameters to lower the estimation variance while reducing the estimation bias. To tackle the problem of regularization parameter determination, R-CSP with aggregation (R-CSP-A) is further proposed, where a number of R-CSPs are aggregated to give an ensemble-based solution. The proposed algorithm is evaluated on data set IVa of BCI Competition III against four other competing algorithms. Experiments show that R-CSP-A significantly outperforms the other methods in average classification performance in three sets of experiments across various testing scenarios, with particular superiority in SSS.

Between classification-error approximation and weighted least-squares learning.

This paper presents a deterministic solution to an approximated classification-error based objective function. In the formulation, we propose a quadratic approximation as the function for achieving smooth error counting. The solution is subsequently found to be related to the weighted least-squares whereby a robust tuning process can be incorporated. The tuning traverses between the least-squares estimate and the approximated total-error-rate estimate to cater for various situations of unbalanced attribute distributions. By adopting a linear parametric classifier model, the proposed classification-error based learning formulation is empirically shown to be superior to that using the original least-squares-error cost function. Finally, it will be seen that the performance of the proposed formulation is comparable to other classification-error based and state-of-the-art classifiers without sacrificing the computational simplicity.

Robust human detection within a highly dynamic aquatic environment in real time.

This paper presents a real-time foreground detection method for monitoring swimming activities at an outdoor swimming pool. Robust performance and high accuracy of detecting objects-of-interest are two central issues of concern. Therefore, in this paper, a considerable amount of attention has been placed on the following aspects: 1) to establish a better method of modeling aquatic background, which exhibitis dynamic characteristics with random spatial movements, and 2) to establish a method of enhancing the visibility of the foreground by removing specular reflection at nighttime. First, the development of a new background modeling method is reported. In the proposed approach, the background is modeled as a composition of homogeneous blob movements. With an implementation of a spatial searching process, the proposed method shows capability in associating and distinguishing movements caused by the background. Hence, this contributes to better performance in foreground detection. On the issue of enhancing the visibility of the foreground, a decision-based filtering scheme is proposed as a preprocessing step. A defined concept term, fluctuation measure, is defined for classifying each pixel to be one of the predefined types. This has allowed suitable spatial or spatiotemporal filters to be applied accordingly for color the compensation step. All of these developments are evaluated by testing live on a busy Olympic-size outdoor public swimming pool. Both qualitative and quantitative evaluations are reported. This provides a comprehensive study of the system.