RESUMO
The effects of single evening doses of alpha-methyldopa and placebo have been compared in 40 women with climacteric hot flushes. The study was designed as a double-blind, randomized and cross-over investigation. Of the 24 patients who completed the study, 15 reported that they preferred the alpha-methyldopa treatment (p greater than 0.05). alpha-methyldopa seemed to affect both the severity (p less than 0.05) and the frequency of climacteric hot flushes (p greater than 0.05). It is concluded that alpha-methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.
Assuntos
Climatério/efeitos dos fármacos , Rubor/tratamento farmacológico , Metildopa/administração & dosagem , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Humanos , Pessoa de Meia-Idade , Distribuição AleatóriaAssuntos
Anestesia Epidural , Procedimentos Cirúrgicos Operatórios , Adolescente , Adulto , Idoso , Anestesia Epidural/efeitos adversos , Criança , Comportamento do Consumidor , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores SexuaisRESUMO
The influence of HLA matching has been studied in a Norwegian material of 147 living related first transplants, 281 cadaveric first transplants and 48 cadaveric second transplants. Graft survival corresponded closely to HLA antigen disparity and degree of MLC response in combinations transplanted with kidneys from living related donors. In patients transplanted with cadaveric grafts. HLA identical and compatible grafts performed significantly better than imcompatible grafts. Matching for HLA-C in addition to HLA-A and -B did not seem to improve graft survival.
