1.
Bioorg Med Chem Lett
; 18(2): 670-3, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18240383
RESUMO
A chemoselective reaction between oxyamines and unprotected, unactivated reducing sugars was used to construct for the first time a panel of linkage-diversified neoglycosides. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage. These results validate linkage diversification through neoglycosylation as a unique and simple strategy to powerfully complement existing methods for the optimization of glycoconjugates.