Perceptual task drives later fixations and long latency saccades, while early fixations and short latency saccades are more automatic.

We used a simple stimulus, dissociating perceptually relevant information in space, to differentiate between bottom-up and task-driven fixations. Six participants viewed a dynamic scene showing the reaction of an elastic object fixed to the ceiling being hit. In one condition they had to judge the object's stiffness and in the other condition its lightness. The results show that initial fixations tend to land in the centre of an object, independent of the task. After the initial fixation, participants tended to look at task diagnostic regions. This fixation behaviour correlates with high perceptual performance. Similarly, low-latency saccades lead to fixations that do not depend on the task, whereas higher latency does.

The color appearance of curved transparent objects.

Studies on colored transparent objects have elucidated potential mechanisms, but these studies have mainly focused on flat filters overlaying flat backgrounds. While they have provided valuable insight, these studies have not captured all aspects of transparency, like caustics, specular reflections/highlights, and shadows. Here, we investigate color-matching experiments with curved transparent objects for different matching stimuli: a uniform patch and a flat filter. Two instructions were tested: simply match the color of the glass object and the test element (patch and flat filter) or match the color of the dye that was used to tint the transparent object (patch). Observers' matches differed from the mean, the most frequent, and the most saturated color of the transparent stimuli, whereas the brightest regions captured the chromaticity, but not the lightness, of patch matches. We applied four models from flat filter studies: the convergence model, the ratios of either the means (RMC) or standard deviations (RSD) of cone excitations, and a robust ratio model. The original convergence model does not fully generalize but does not perform poorly, and with modifications, we find that curved transparent objects cause a convergence of filtered colors toward a point in color space, similar to flat filters. Considering that, the RMC and robust ratio models generalized more than the RSD, with the RMC performing best across the stimuli we tested. We conclude that the RMC is probably the strongest factor for determining the color. The RSD seems instead to be related to the perceived "clarity" of glass objects.

Geometrical structure of perceptual color space: Mental representations and adaptation invariance.

Similarity between percepts and concepts is used to accomplish many everyday tasks, e.g., object identification; so this similarity is widely used to construct geometrical spaces that represent stimulus qualities, but the intrinsic validity of the geometry, i.e., whether similarity operations support a particular geometry, is almost never tested critically. We introduce an experimental approach for equating relative similarities by setting perceived midpoints between pairs of stimuli. Midpoint settings are used with Varignon's Theorem to test the intrinsic geometry of a representation space, and its mapping to a physical space of stimuli. For perceptual color space, we demonstrate that geometrical structure depends on the mental representation used in judging similarity: An affine geometry was valid when observers used an opponent-color mental representation. Similarities based on a conceptual space of complementary colors thus power a geometric coordinate system. An affine geometry implies that similarity can be judged within straight lines and across parallel lines, and its neural coding could involve ratios of responses. We show that this perceptual space is invariant to changes in illumination color, providing a formal justification to generalize color constancy results measured for color categories, to all of color space. The midpoint measurements deviate significantly from midpoints in the extensively used "uniform" color spaces CIELAB and CIELUV, showing that these spaces do not provide adequate metric representation of perceived colors. Our paradigm can thus test for intrinsic geometrical assumptions underlying the representation space for many perceptual modalities, and for the extrinsic perceptual geometry of the space of physical stimuli.

Disentangling simultaneous changes of surface and illumination.

Retinally incident light is an ambiguous product of spectral distributions of light in the environment and their interactions with reflecting, absorbing, and transmitting materials. An ideal color constant observer would unravel these confounded sources of information and account for changes in each factor. Scene statistics have been proposed as a way to compensate for changes in the illumination, but few theories consider changes of 3-dimensional surfaces. Here, we investigated the visual system's capacity to deal with simultaneous changes in illumination and surfaces. Spheres were imaged with a hyperspectral camera in a white box and their colors, as well as that of the illumination were varied along "red-green" and "blue-yellow" axes. Both the original hyperspectral images and replica scenes rendered with Mitsuba were used as stimuli, including rendered scenes with Glavens (Acta Psychologica, 2009, 132, 259-266). Observers viewed sequential, random pairs of our images, with either the whole scene, only the object, or only a part of the background being present. They judged how much the illuminant and object color changed on a scale of 0-100%. Observers could extract simultaneous illumination and reflectance changes when provided with a view of the whole scene, but global scene statistics did not fully account for their behavior, while local scene statistics improved the situation. There was no effect of color axis, shape, or simulated vs. original hyperspectral images. Observers appear to be making use of various sources of local information to complete the task.

Hyperspectral database of fruits and vegetables.

We have built a hyperspectral database of 42 fruits and vegetables. Both the outside (skin) and inside of the objects were imaged. We used a Specim VNIR HS-CL-30-V8E-OEM mirror-scanning hyperspectral camera and took pictures at a spatial resolution of ∼57 px/deg by 800 pixels at a wavelength resolution of ∼1.12 nm. A stable, broadband illuminant was used. Images and software are freely available on our webserver (http://www.allpsych.uni-giessen.de/GHIFVD; pronounced "gift"). We performed two kinds of analyses on these images. First, when comparing the insides and outsides of the objects, we observed that the insides were lighter than the skins, and that the hues of the insides and skins were significantly correlated (circular correlation=0.638). Second, we compared the color distribution within each object to corresponding human color discrimination thresholds. We found a significant correlation (0.75) between the orientation of ellipses fit to the chromaticity distributions of our fruits and vegetables with the orientations of interpolated MacAdam discrimination ellipses. This indicates a close relationship between sensory processing and the characteristics of environmental objects.

Categorizing natural color distributions.

The natural objects that we are surrounded with virtually always contain many different shades of color, yet the visual system usually categorizes them into a single color category. We examined various image statistics and their role in categorizing the color of leaves. Our subjects categorized photographs of autumn leaves and versions that were manipulated, including: randomly repositioned pixels, leaves uniformly colored with their mean color, leaves that were made by reflecting the original leaves' chromaticity distribution about their mean ("flipped leaves"), and simple patches colored with the mean colors of the original leaves. We trained a linear classifier with a set of image statistics in order to predict the category that each object was assigned to. Our results show that the mean hue of an object is highly predictive of the natural object's color category (>90% accuracy) and observers' choices are consistent with their use of unique yellow as a decision boundary for classification. The flipped leaves produced consistent changes in color categorization that are possibly explained by an interaction between the color distributions and the texture of the leaves.

Seeing lightness in the dark.

From intense sunlight in bright snow down to a moonless night in a dark forest, we can use light to recognize objects and guide our actions. This remarkable range mainly rests on having two different types of photoreceptors, the rods and the cones. The cones are active under daylight conditions, allowing high acuity and color vision. Rods are mainly active under very dim illumination conditions and have an exquisite sensitivity to light [1]. There are obvious detriments to visual perception in near darkness, such as a central scotoma, reduced motion perception [2], and most of all a lack of color [3]. There is only one type of rod, and thus intensity and wavelength differences cannot be disentangled when only the rods are active. This is captured well by the old saying "at night all cats are gray", meaning that different colors inevitably get mapped onto different shades of gray. Here we show that the perception of lightness is also different for night vision: our results indicate that surfaces that appear to be white under daylight conditions, at best, appear medium gray under night vision, suggesting that activation of the cones is necessary for the perception of white.

Retinal adaptation abnormalities in primary open-angle glaucoma.

PURPOSE: Dynamic color and brightness adaptation are crucial for visual functioning. The effects of glaucoma on retinal ganglion cells (RGCs) could compromise these functions. We have previously used slow dynamic changes of light at moderate intensities to measure the speed and magnitude of subtractive adaptation in RGCs. We used the same procedure to test if RGC abnormalities cause slower and weaker adaptation for patients with glaucoma when compared to age-similar controls. We assessed adaptation deficits in specific classes of RGCs by testing along the three cardinal color axes that isolate konio, parvo, and magno RGCs. METHODS: For one eye each of 10 primary open-angle glaucoma patients and their age-similar controls, we measured the speed and magnitude of adapting to 1/32 Hz color modulations along the three cardinal axes, at central fixation and 8° superior, inferior, nasal, and temporal to fixation. RESULTS: In all 15 comparisons (5 locations × 3 color axes), average adaptation was slower and weaker for glaucoma patients than for controls. Adaptation developed slower at central targets than at 8° eccentricities for controls, but not for patients. Adaptation speed and magnitude differed between affected and control eyes even at retinal locations showing no visual field loss with clinical perimetry. CONCLUSIONS: Neural adaptation is weaker in glaucoma patients for all three classes of RGCs. Since adaptation abnormalities are manifested even at retinal locations not exhibiting a visual field loss, this novel form of assessment may offer a functional insight into glaucoma and an early diagnosis tool.

Eye movements and the neural basis of context effects on visual sensitivity.

The effects of context on visual sensitivity are well established (e.g., sensitivity to luminance flicker is substantially higher on mean-gray surrounds than on white or black surrounds). The neural mechanisms generating context effects, however, remain unresolved. In the absence of direct tests, some theories invoke enhancement of edges by lateral inhibition, whereas others rely on transients caused by miniature eye movements that maintain fixation. We first replicated the luminance results on human observers and found unexpectedly that sensitivity to red-green flicker is also affected by surround color, being substantially higher on mean-gray surrounds than on red or green surrounds. To identify the neural bases of both context effects, we used in vivo electrophysiological recordings of primate magnocellular and parvocellular ganglion cell responses to luminance and red-green modulations, respectively. To test neuronal sensitivity to stationary edge contrast, neuronal responses were measured at various distances from the modulation edge against various surrounds. We found no evidence of enhanced responses to stationary edges on any surrounds, ruling out lateral inhibition-type explanations. To simulate the effects of eye movements, target patches were abruptly displaced while measuring responses. Abruptly displaced edges evoked vigorous transient responses that were selective for modulation-phase on mean-gray surrounds, but were phase-invariant on other surrounds. Eye movements could thus enhance detection of flicker on mean-gray surrounds, and neurometric analyses supported a primary role for eye movements in enhancing sensitivity. In addition, the transformation of spatial edges to transient neuronal responses by eye movements provides the signals for detecting luminance and color edges in natural scenes.

Neural locus of color afterimages.

After fixating on a colored pattern, observers see a similar pattern in complementary colors when the stimulus is removed [1-6]. Afterimages were important in disproving the theory that visual rays emanate from the eye, in demonstrating interocular interactions, and in revealing the independence of binocular vision from eye movements. Afterimages also prove invaluable in exploring selective attention, filling in, and consciousness. Proposed physiological mechanisms for color afterimages range from bleaching of cone photopigments to cortical adaptation [4-9], but direct neural measurements have not been reported. We introduce a time-varying method for evoking afterimages, which provides precise measurements of adaptation and a direct link between visual percepts and neural responses [10]. We then use in vivo electrophysiological recordings to show that all three classes of primate retinal ganglion cells exhibit subtractive adaptation to prolonged stimuli, with much slower time constants than those expected of photoreceptors. At the cessation of the stimulus, ganglion cells generate rebound responses that can provide afterimage signals for later neurons. Our results indicate that afterimage signals are generated in the retina but may be modified like other retinal signals by cortical processes, so that evidence presented for cortical generation of color afterimages is explainable by spatiotemporal factors that modify all signals.

Pandemic (H1N1) 2009 outbreak at Canadian Forces cadet camp.

We conducted a case-control study to describe the clinical and epidemiologic characteristics of an outbreak of pandemic (H1N1) 2009 at a Canadian military cadet training center. We found that asthma and obesity confer greater risk for infection. Viral shedding was detected by PCR up to 18 days after symptom onset.

Transitions between central and peripheral vision create spatial/temporal distortions: a hypothesis concerning the perceived break of the curveball.

BACKGROUND: The human visual system does not treat all parts of an image equally: the central segments of an image, which fall on the fovea, are processed with a higher resolution than the segments that fall in the visual periphery. Even though the differences between foveal and peripheral resolution are large, these differences do not usually disrupt our perception of seamless visual space. Here we examine a motion stimulus in which the shift from foveal to peripheral viewing creates a dramatic spatial/temporal discontinuity. METHODOLOGY/PRINCIPAL FINDINGS: The stimulus consists of a descending disk (global motion) with an internal moving grating (local motion). When observers view the disk centrally, they perceive both global and local motion (i.e., observers see the disk's vertical descent and the internal spinning). When observers view the disk peripherally, the internal portion appears stationary, and the disk appears to descend at an angle. The angle of perceived descent increases as the observer views the stimulus from further in the periphery. We examine the first- and second-order information content in the display with the use of a three-dimensional Fourier analysis and show how our results can be used to describe perceived spatial/temporal discontinuities in real-world situations. CONCLUSIONS/SIGNIFICANCE: The perceived shift of the disk's direction in the periphery is consistent with a model in which foveal processing separates first- and second-order motion information while peripheral processing integrates first- and second-order motion information. We argue that the perceived distortion may influence real-world visual observations. To this end, we present a hypothesis and analysis of the perception of the curveball and rising fastball in the sport of baseball. The curveball is a physically measurable phenomenon: the imbalance of forces created by the ball's spin causes the ball to deviate from a straight line and to follow a smooth parabolic path. However, the curveball is also a perceptual puzzle because batters often report that the flight of the ball undergoes a dramatic and nearly discontinuous shift in position as the ball nears home plate. We suggest that the perception of a discontinuous shift in position results from differences between foveal and peripheral processing.

Accuracy of diagnostic tests for Cushing's syndrome: a systematic review and metaanalyses.

CONTEXT: The diagnosis of Cushing's syndrome (CS) requires the use of tests of unregulated hypercortisolism that have unclear accuracy. OBJECTIVE: Our objective was to summarize evidence on the accuracy of common tests for diagnosing CS. DATA SOURCES: We searched electronic databases (MEDLINE, EMBASE, Web of Science, Scopus, and citation search for key articles) from 1975 through September 2007 and sought additional references from experts. STUDY SELECTION: Eligible studies reported on the accuracy of urinary free cortisol (UFC), dexamethasone suppression test (DST), and midnight cortisol assays vs. reference standard in patients suspected of CS. DATA EXTRACTION: Reviewers working in duplicate and independently extracted study characteristics and quality and data to estimate the likelihood ratio (LR) and the 95% confidence interval (CI) for each result. DATA SYNTHESIS: We found 27 eligible studies, with a high prevalence [794 (9.2%) of 8631 patients had CS] and severity of CS. The tests had similar accuracy: UFC (n = 14 studies; LR+ 10.6, CI 5.5-20.5; LR- 0.16, CI 0.08-0.33), salivary midnight cortisol (n = 4; LR+ 8.8, CI 3.5-21.8; LR- 0.07, CI 0-1.2), and the 1-mg overnight DST (n = 14; LR+ 16.4, CI 9.3-28.8; LR- 0.06, CI 0.03-0.14). Combined testing strategies (e.g. a positive result in both UFC and 1-mg overnight DST) had similar diagnostic accuracy (n = 3; LR+ 15.4, CI 0.7-358; LR- 0.11, CI 0.007-1.57). CONCLUSIONS: Commonly used tests to diagnose CS appear highly accurate in referral practices with samples enriched with patients with CS. Their performance in usual clinical practice remains unclear.

Postoperative deep vein thrombosis prophylaxis: a retrospective analysis in 1000 consecutive hip fracture patients treated in a community hospital setting.

The occurrence of deep vein thrombosis (DVT) following cases of major trauma, in particular pelvic and hip fracture, has ranged from 36% to 60%, depending on the study quoted and the method of detection. The frequency of fatal pulmonary embolism (PE) has been reported as 0.5%-12.9% of the cases. A retrospective study of 1000 consecutive hip fracture patients in a community hospital setting reveals that 95% received a combination of mechanical and pharmacologic prophylaxis for prevention of DVT. Sixty-one patients were excluded for insufficient data, leaving 939 for analysis. There were 724 female patients with an average age of 83 years and 215 male patients with an average age of 78 years. Fifty-one patients (18.4%) received no prophylaxis in the eligible population. Three hundred eighty-seven patients (41.2%) received only aspirin as the pharmacologic agent for anticoagulation. Four hundred twenty-nine patients (45.6%) were treated with the low-molecular-weight heparin (LMWH), enoxaparin. Ten patients (1.1%) received heparin for anticoagulation and 17 patients (1.8%) were treated with warfarin. A total of 43 patients received a combination of therapies. Four hundred ninety-five of the patients used concomitant intermittent pneumatic compression in addition to pharmacologic prophylaxis. There were 15 perioperative deaths from all causes, including five cases of DVT two distal and three proximal). One distal DVT occurred prior to surgery. A second distal DVT and one fatal PE occurred in the aspirin group. The rates of minor bleeding complications in the aspirin group, the < 12-hour postoperative dosing of the enoxaparin group, and the 12 to 24-hour postoperative dosing of the enoxaparin group were 3.1%, 5.7%, and 2.8%, respectively. There were no major bleeds in the aspirin group and 0.9% in the enoxaparin group. The LMWH group also had two proximal DVTs but no PEs. The combination of a relatively short half-life, predictable pharmacokinetics, and favorable safety profile makes enoxaparin an excellent drug for use in hip fracture patients. Additional trials will be necessary to establish an optimal duration of prophylaxis in this population.

Pathophysiology of headache associated with cough in patients with Chiari I malformation.

OBJECT: The aim of this study was to evaluate the pathophysiology underlying headache associated with cough in patients with Chiari I tonsillar abnormality. The authors hypothesized that peak intrathecal pressure during coughing is higher in patients with headache aggravated by cough than in patients without or in healthy volunteers. In addition, the authors evaluated the use of intrathecal pressure during cough as a means of assessing obstruction to the free flow of cerebrospinal fluid (CSF) at the craniocervical junction. METHODS: Twenty-six adult patients with Chiari I malformation and syringomyelia, four adult patients with Chiari I malformation without syringomyelia, and 15 healthy volunteers were prospectively studied. Testing before surgery included the following: 1) clinical evaluation for the presence of headache associated with cough; and 2) evaluation of lumbar subarachnoid pressure at rest, during three to five coughs, while performing the Valsalva maneuver, during jugular compression, and after removal of CSF. Patients underwent suboccipital craniectomy, C-1 laminectomy, and duraplasty. Testing was repeated 6 months after surgery. CONCLUSIONS: Peak intrathecal pressures during cough and at baseline were elevated in patients with headache associated with cough compared with either patients without headache or healthy volunteers. After surgery, intrathecal pressures during cough were significantly lower than preoperative values and headache aggravated by cough was resolved partially or completely. Headache linked to coughing in patients with Chiari I malformation is associated with sudden increased intrathecal pressure caused by obstruction to the free flow of CSF in the subarachnoid space.