Pharmacokinetics of CuDIPS in mice.

Pharmacokinetic evaluation of Cu(II)2(3,5-diisopropylsalicylate)4(H2O)2 (CuDIPS), a copper complex with anticancer activity in mice, showed rapid absorption into the circulation after subcutaneous (SC) injection of a 0.50mumol, 0.75 mumol or 1.0 mumol dose. A direct relationship was observed between peak plasma copper concentration (one or two hours) and dose. Rate of plasma release also appeared to be dose related. The lowest dose of CuDIPS had no effect on plasma zinc levels; higher doses produced significant increases, but only at one hour. Rapid absorption into the blood (apparent peak in concentration, Tmax, at 0.5 hours) was also found in studies to determine distribution of 67Cu after SC injection of 67Cu and 14C double-labeled CuDIPS (50 mumol/kg body weight). Distribution to other tissues and organs occurred less rapidly with apparent peak 67Cu concentrations at three hours after administration in femur (bone marrow) and intestine, and at six hours in spleen and thymus.

Bioavailable copper complexes offer a physiologic approach to treatment of chronic diseases.

Copper (II)2(3,5-Diisopropylsalicylate)4(H2O)2 has been found to have antiinflammatory, antiulcer, anticonvulsant, anticancer, anticarcinogenic, antimutagenic, and radiation recovery activities and it prevents reperfusion injury. To study pharmacokinetic parameters accounting for these pharmacological effects the double labeled 67Cu(II)2(carboxy-14C-3,5-diisopropylsalicylate)4 complex was synthesized and used to obtain these parameters. Treatment of mice with 1 mumol of this complex revealed that 67Cu was distributed to blood, liver, kidney, intestine, lung, thymus, femur, muscle, spleen, brain, urine, and feces within 0.5 hr and patterned changes in 67Cu content of these tissues and excreta were found throughout the 96 hr term of this study.

Distribution of radionuclides in Dardanelle Reservoir sediments.

Natural and reactor-discharged gamma-ray emitting radionuclides were measured in Dardanelle Reservoir surface sediments taken near the Arkansas Nuclear One Power Plant site. Samples represented several water depths and particle sizes, at 33 locations, in a field survey conducted in early September 1980. Radionuclide contents of dry sediments ranged as follows: natural radioactivity (40K as well as uranium and thorium decay products) 661-1210 Bq/kg; and reactor discharged radioactivity (137Cs, 134Cs, 60Co,, 58Co, 54Mn), no detectable activity to 237 Bq/kg. In general, radionuclide contents were positively correlated with decreasing sediment particle size. The average external whole-body and skin doses from all measurable reactor-discharged radionuclides were calculated according to the mathematical formula for determining external dose from sediment given by the U.S. Nuclear Regulatory Commission (NRC). Inside the discharge embayment near the reactor discharge canal, the doses were 1.7 X 10(-3) mSv/yr to the whole body and 2.0 X 10(-3) mSv/yr to the skin. Outside this area, the doses were 0.15 X 10(-3) and 0.18 X 10(-3) mSv/yr to the whole body and skin, respectively.