Microbial metabolomic responses to changes in temperature and salinity along the western Antarctic Peninsula.

Seasonal cycles within the marginal ice zones in polar regions include large shifts in temperature and salinity that strongly influence microbial abundance and physiology. However, the combined effects of concurrent temperature and salinity change on microbial community structure and biochemical composition during transitions between seawater and sea ice are not well understood. Coastal marine communities along the western Antarctic Peninsula were sampled and surface seawater was incubated at combinations of temperature and salinity mimicking the formation (cold, salty) and melting (warm, fresh) of sea ice to evaluate how these factors may shape community composition and particulate metabolite pools during seasonal transitions. Bacterial and algal community structures were tightly coupled to each other and distinct across sea-ice, seawater, and sea-ice-meltwater field samples, with unique metabolite profiles in each habitat. During short-term (approximately 10-day) incubations of seawater microbial communities under different temperature and salinity conditions, community compositions changed minimally while metabolite pools shifted greatly, strongly accumulating compatible solutes like proline and glycine betaine under cold and salty conditions. Lower salinities reduced total metabolite concentrations in particulate matter, which may indicate a release of metabolites into the labile dissolved organic matter pool. Low salinity also increased acylcarnitine concentrations in particulate matter, suggesting a potential for fatty acid degradation and reduced nutritional value at the base of the food web during freshening. Our findings have consequences for food web dynamics, microbial interactions, and carbon cycling as polar regions undergo rapid climate change.

Ten-year incidence and time trends of railway suicides in Germany from 1991 to 2000.

BACKGROUND: Railway suicides strongly impact psychological and socioeconomic aspects of the railway company, its employees and possible eye witnesses. We aimed to assess the incidence of railway suicides compared with the total burden of suicides in Germany and its time trend over a 10-year observation period. METHODS: From 1991 to 2000, a total of 8,653 fatal railway suicides were recorded by the national central registry of all passenger accidents on the German railway net. To assess time trends, the average annual percentage change (AAPC) of the number of suicides was estimated using Poisson regression. Adjustments were made for two age groups and measures of availability. RESULTS: Railway suicides accounted for 7.0% (annual range 5.0-7.9%) of all suicides in Germany. The time trend of the number of suicides by all means declined, with a significant stronger decline for older subjects [AAPC -2.2; 95% confidence intercal (CI) -3.0 to -1.5; and -4.2; 95% CI -5.2 to -3.0]. An AAPC of 1.8% (95% CI 0.1-3.4) indicated an increasing time trend of the number of railway suicides for subjects aged 65 years exhibited a strong decrease (AAPC -6.2%; 95% CI -10.9 to -1.3). CONCLUSIONS: The present study demonstrates different time trends for railway suicides compared with all suicides. It underlines the urgent need for amplified research efforts in the particular field of railway suicides. Further examinations are recommended, in particular concerning possible reasons for this suicidal method.

Factors associated with failed and completed railway suicides.

BACKGROUND: The present analysis aimed to assess the proportion of survivors of railway suicides and to compare survivors and completers in terms of personal characteristics and temporal patterns surrounding the event, to identify potential differences between those who completed suicide and those who survived a serious suicide attempt. METHODS: A total of 5731 suicide victims (including 4003 cases with complete documentation on sex) of the German central railway registry of person accidents covering a six-year observation period of 1997 to 2002 and satisfying the operational definition of an act of suicidal behaviour according to the ICD-10 were included into the data set. To assess the impact of sex, age, local and temporal factors on case fatality, a multivariate logistic regression analysis was performed. RESULTS: A minority of 540 (9.4%) subjects survived the suicidal event leading to a fatal to non-fatal ratio of 9.6:1 (chi(2)-test for equal proportions, p<0.001). Multivariate logistic regression analysis identified the following variables as risk factors for fatal outcome: men (vs. women: Odds ratio (OR)=2.05; 95% CI: 1.65-2.56), night (vs. day: OR=1.80; 95% CI: 1.43-2.27), open track (vs. station area: OR=2.95; 95% CI: 2.36-2.67) and main railway line (vs. local railway line: OR=2.29; 95% CI: 1.43-3.68). Interactions between two factors on fatal outcome were multivariate tested but showed no significance. CONCLUSIONS: Close to 10% of all railway suicide attempts are nonfatal. Fatality of suicidal behaviour on railway tracks is significantly associated with male sex pointing to a certain degree of ambivalence. Higher odds to die on open track area, fast track lines and during night-time suggest a reduced opportunity to survive due to circumstances.

[Regional and local clusters of railway suicides]. / Regionale und örtliche Verteilungsmuster von Bahnsuiziden.

BACKGROUND AND METHOD: Suicide research has identified regional and local clusters of increased suicide prevalence. As part of a comprehensive prevention strategy to fight railway suicides, we sought to identify such particular clusters on the German Railway net (total length 37,080 km) during a 6-year observation period (1997-2002). Data stem from the central registry of all person accidents on the German Railway net. RESULTS: During the observation period, a total of 5,731 suicides (in average 18 cases per week) were registered. Against expectation derived from distribution patterns in the general suicide research, we found a preponderance in the southern part compared to the northern part of Germany and a significant downward trend from west to east ( p=0.004). Most suicides occurred on open track (66%) compared to suicides at railway platforms (34%). We identified 16 places of high risk with 6 to 29 suicides per railway km. Of these high risk places, 75% were in the proximity of psychiatric hospitals. CONCLUSION: Increased awareness for regional and local suicide clusters, initiatives to reduce the accessibility and warning infra-red beams are among recommendations for suicide prevention derived from these data.

Sex-specific time patterns of suicidal acts on the German railway system. An analysis of 4003 cases.

OBJECTIVE: To examine sex-specific time patterns of suicidal behaviour on railway tracks as basis of suicide preventive strategies. METHOD: Cases were derived from the National Central Registry of all person accidents on the German railway net (STABAG) between 1997 and 2002 satisfying the operational definition of suicidal behaviour and included sex, age, date, clock time and outcome of the incidence. RESULTS: Over the 6-year observation period, 4003 fatal and non-fatal suicidal incidences were documented. Male to female ratio was 2.70:1 (p<0.0001). The female subgroup was significantly older than the male subgroup (p<0.0001). The monthly distribution revealed a bimodal pattern (p=0.01), particularly in men younger than 65 years, with an excess risk in April and September. This circannual pattern attenuated in the second half of the observation period as shown by adjusted Poisson regression. Monday and Tuesday proved to be high risk days for both sexes. For males and females, a bimodal diurnal distribution pattern with a morning and an evening peak was observed. While both sexes followed the same pattern in the winter half year, in summer females showed a pronounced excess risk in the morning hours while for men the evening peak was substantially amplified (p<0.0001). Risk assessment revealed a marked broadening by approximately 6 h of the time window in the summer half year compared to the winter half year. LIMITATIONS: About 30% of cases were excluded because of missing data on sex specification. However, cases with and without sex information did not differ significantly in the variables under investigation. CONCLUSION: The analysis revealed marked seasonal, weekly and diurnal peaks of railway suicide intensity. Differences between men and women indicate sex-specific processes underlying their suicidal behaviour. The findings may increase alertness of railway and security personal for particular vulnerable time windows of excess risk for railway suicides.

[Confrontation instead of avoidance. Why anxiety patients should face the causes]. / Konfrontieren statt vermeiden. Warum Angstpatienten sich ihren Auslösern stellen müssen.

Psychiatric management forms the basis of any integrated psychiatric treatment. It serves to maximize the patient's level of performance, safety and quality of life. It also involves the patient's family members--who are usually indirectly affected by the disorder and may provide support during the course of treatment--in the therapeutic strategy. The psychiatric management of anxiety disorders can be effectively carried out, also by the family doctor familiar with mental disorders, since the GP is usually the first primary care instance to be approached by the patient, who assumes an underlying organic cause rather than a mental problem. Within the framework of psychiatric management, the family doctor should be kept fully informed of the individual steps in the treatment strategy, and coordinate the necessary interventions by other care providers. By taking psychoeducative measures he can already initiate effective treatment, and may create a positive atmosphere in which treatment-requiring anxiety can be openly discussed and perhaps partly resolved. Talking to the patient about early symptoms may help to avoid severe relapses. Psychiatric management as part of the general practitioner's activities helps achieve the goal of integrating the treatment of patients with anxiety disorders in the doctor's office.

Disinhibition of libido: an adverse effect of SSRI?

BACKGROUND: The article focuses on adverse drug reactions (ADR) to selective serotonin reuptake inhibitors (SSRI) concerning libido and sexual behaviour: cases of disinhibition of libido observed at the Psychiatric Hospital of Kilchberg near Zurich are described. METHOD: Within the scope of a drug safety program, the physicians of the hospital are regularly asked about severe and unexpected events under drug treatment. RESULTS: During remission of depression, five outpatients noticed an increase of libido experienced as strange to them, i.e. preoccupation with sexual thoughts, first appearance of promiscuity, of unsafe sexual intercourse, and of excessive pursuit of pornography, respectively, during administration, change in dose or discontinuation of SSRI. DISCUSSION: The case studies suggest that SSRI treatment might be associated with increase and disinhibition of libido. The phenomena are discussed as a "selective switch" into partly manic symptomatology or an induction of mixed states with prevailing sexual symptoms.

Identifying somatization disorder in a population-based health examination survey: psychosocial burden and gender differences.

Despite its enormous medical burden, little is known about the epidemiology of somatization in the community. The present study screened a representative population-based survey of 7,466 subjects in the age range of 25 to 69 years for the occurrence of somatization. A total of 137 (1.84%) individuals experienced six or more symptoms from at least two different body sites without an identifiable organic cause. These patients exhibited a lower quality of life (P < or = 0.0001) and suffered from higher levels of emotional stress (P < or = 0.0001) than their counterparts in the healthy subsample (n=906). Somatization was not associated with a medical diagnosis, but disability days, the use of medical services, and the level of medication was higher in the somatization disorder group (P < or = 0.004). The somatization risk was only 1.6-fold higher for women in comparison to men but escalated for women rapidly to an approximately 4-fold risk when being female was combined with low social class and high emotional distress. Against expectation, the somatization risk for men also mounted 3-fold under the identical risk constellation.

[Model creation in art therapy. A sculpture project at a psychiatric clinic]. / Zum plastischen Gestalten in der Kunsttherapie. Ein Bildhauerprojekt an einer Psychiatrischen Klinik.

Therapeutic modelling has found little attention in the literature. For the first time, the present article reports about sculptural work in psychiatric art therapy. Since 1994 the Psychiatric Hospital Kilchberg/Zürich is carrying out a sculpture project, in which about 30 patients work with sand- or limestone for 2 1/2 hours daily, cared for by eight therapists and protected by detailed safety regulations. At the beginning and the end of each afternoon the patients stand in a circle to communicate inner mood and ideas about the work. An exposition at the end of the project gives the opportunity to demonstrate the sculptures to family, friends and clinical staff. Until now there have been only positive experiences, which speak in favour of a wider use of sculpture in psychiatric art therapy. Sculptural work stimulates the vitality of the patients, who are challenged to use their willpower adaptedly and rhythmically. Especially on patients with autodestructive tendencies sculptural work seems to exert a beneficial influence.

Differential response to lithium and carbamazepine in the prophylaxis of bipolar disorder.

In a randomized, prospective, multicenter study with an observation period of 2.5 years, the differential prophylactic efficacy of lithium versus carbamazepine was compared in 171 patients fulfilling DSM-IV criteria for bipolar disorder. Serum drug levels were 0.6+/-0.1 mmol/L for lithium and 6.1+/-1.3 microg/mL for carbamazepine. Patients were subdivided into a classical subgroup (bipolar I patients without mood-incongruent delusions and without comorbidity, N = 67) and a nonclassical subgroup including all other patients (N = 104). Classical bipolar patients had a lower rehospitalization rate with lithium than with carbamazepine prophylaxis (p = 0.005). For the nonclassical group, a trend in favor of carbamazepine was found. In the lithium group, there was a positive association between hospitalization rate and number of nonclassical features (bipolar II/not otherwise specified, mood-incongruent delusions, comorbidity; p = 0.035). For carbamazepine, this association was negative (p = 0.033). Analyses including mixed states as an additional nonclassical feature confirmed the results. In conclusion, lithium seems to be superior to carbamazepine in treating classical bipolar cases. Patients with nonclassical features might profit more from prophylaxis with carbamazepine, which seems to have a broader spectrum of activity.

[Sleep deprivation in inpatient treatment of depression. A report of experiences]. / Wachtherapie in der stationären Depressionsbehandlung. Ein Erfahrungsbericht.

Sleep deprivation or "stay awake"-therapy), given in addition to drug therapy, is seen as an effective anti-depressive treatment with actually no side effects. Nevertheless, it is not regularly and systematically used. A reason for this might be doubts about its feasibility in psychiatric hospitals without specialised depression wards. Only a few reports exist on the practical aspects of sleep deprivation. The present article informs about the "stay awake"-therapy on 101 depressive patients (in the mean 25 patient-nights per month), carried out at the Psychiatric Hospital Sanatorium Kilchberg/Zurich. The patients (age between 19 and 76, mean 47 years) participated on average in 4.4 partial sleep deprivations. 72% participated at least for a set of three nights. One staff person takes care of a group of at most five patients. Indication, organisation, night programme, care and possible strains are reported. A stay awake night (three times a week) consists of breakfast, games, conversations, taking two walks, and discussions about depression and about treatment (psychoeducation), with the aim to avoid naps and to provide a pleasant social event. The experiences made with serial partial sleep deprivation are encouraging.

Lithium versus carbamazepine in the maintenance treatment of bipolar disorders--a randomised study.

In a randomised multicentre study, the prophylactic efficacy of lithium and carbamazepine was compared in 144 patients with bipolar disorder (74 vs. 70 patients; observation period: 2.5 years; lithium serum level: 0.63 +/- 0.12 mmol/l, carbamazepine dose: 621 +/- 186 mg/day). Hospitalisations, recurrences, need of psychotropic comedication and adverse effects prompting discontinuation were defined as treatment failures. Survival analyses regarding hospitalisations and recurrences showed no statistically significant differences between both drugs. Results were distinctly in favour of lithium, considering recurrences combined with comedication (P = 0.041) and/or adverse effects (P = 0.007). Whereas adverse effects prompting discontinuation were more frequent under carbamazepine (9 vs. 4, ns), lithium patients reported more often slight/moderate side effects (61% vs. 21% after 2.5 years; P = 0.0006). In completers, recurrences occurred in 28% (lithium) vs. 47% (carbamazepine) of the patients (P = 0.06). Lithium seems to be superior to carbamazepine in maintenance treatment of bipolar disorder, in particular when applying broader outcome criteria including psychotropic comedication and severe side effects.

Lithium vs carbamazepine in the maintenance treatment of schizoaffective disorder: a randomised study.

In a randomised multicentre study, the prophylactic efficacy of lithium and carbamazepine was compared in schizoaffective disorder. A total of 90 ICD-9 schizoaffective patients were included in the maintenance phase (2.5 years). They were also diagnosed according to RDC and DSM-III-R and classified into subgroups. Mean serum levels were 0.58 +/- 0.12 mmol/l for lithium and 6.4 +/- 1.5 micrograms/ml for carbamazepine (mean dose 643 +/- 179 mg/d). Outcome criteria were hospitalisation, recurrence, concomitant psychotropic medication and adverse effects leading to discontinuation. There were more non-completers under carbamazepine than under lithium (p = 0.02). Survival analyses demonstrated no significant differences between lithium and carbamazepine in treatment outcome. Patient's ratings of side effects (p = 0.003) and treatment satisfaction (p = 0.02) favoured carbamazepine. Following the RDC criteria, patients of the schizodepressive and non-classifiable type did better under carbamazepine (p = 0.055 for recurrence), whereas in the schizomanic patients equipotency of both drugs was found. Applying DSM-III-R, carbamazepine demonstrated a superiority in the patient group with more schizophrenia-like or depressive disorders (p = 0.040 for recurrence), but not in patients fulfilling the DSM-III-R criteria of bipolar disorder. Lithium and carbamazepine seem to be equipotent alternatives in the maintenance treatment of broadly defined schizoaffective disorders. However, in subgroups with depressive or schizophrenia-like features and regarding its long-term tolerability carbamazepine seems to be superior.

Comparative efficacy of lithium and amitriptyline in the maintenance treatment of recurrent unipolar depression: a randomised study.

The present study, including 81 depressive patients, compares the prophylactic efficacy of lithium and amitriptyline in recurrent unipolar depression over a treatment period of 2.5 years in a randomised multicentre design. Hospitalisation, re-emergence of depressive or subdepressive recurrences, unwanted side-effects and need of concomitant psychotropic medication were considered to indicate treatment failures. Average dosage for amitriptyline was 98 +/- 37 mg/day, average lithium blood level was 0.59 +/- 0.12 mmol/l. Survival analyses demonstrated a significant superiority of lithium (P = 0.015) regarding the outcome criteria 'recurrences and/or subclinical recurrences' and non-significantly better results of lithium compared to amitriptyline concerning 'recurrence' (P = 0.059) or 'recurrence and/or concomitant medication' (P = 0.066).