Mechanical thrombectomy with Embolus Retriever with Interlinked Cages device for medium vessel occlusions: First pass results and safety profile.

BACKGROUND: Reperfusion of medium vessel occlusions is correlated with good outcomes. However, optimal techniques and medical devices are still unclear. In this study, we sought to evaluate the safety and efficacy of mechanical thrombectomy with Embolus Retriever with Interlinked Cages (ERIC™) retrieval device in patients with acute ischemic stroke due to distal medium vessel occlusions. METHODS: A retrospective review of the prospectively collected mechanical thrombectomy database revealed 50 patients who had fulfilled the inclusion criteria. The data collected includes clinical patient characteristics, procedural measures, timestamps at each stage, and patient outcomes. Intravenous thrombolytics application, pre- and post-intervention imaging findings, device-related adverse events and any type of intracranial hemorrhage were recorded. RESULTS: There were 25 men (50%) and 25 women (50%) with a median of 67 years (interquartile range (IQR) 41-84). Median presenting NIHSS was 14 (IQR, 3-23). First pass rates were: eTICI3 in 16 cases (32%), eTICI-2c in eight cases (16%), eTICI-2B67 in nine cases (10%), eTICI2B50 in three cases (6%) and mTICI 0-2A in 18 cases (36%). Final recanalization rate of mTICI 2b-3 was 90% and 2c-3 was 70%. CONCLUSION: In conclusion, the ERIC thrombectomy device offers a high rate of first-pass success along with a favorable safety profile. Larger series and multi-center studies are needed for further investigation.

RapidpulseTM cyclic aspiration system for acute ischemic stroke due to large vessel occlusions.

BACKGROUND: The best strategy to achieve optimal reperfusion outcomes during mechanical thrombectomy remains to be defined. The RapidPulseTM Cyclic Aspiration System is a novel technology, delivering high-frequency pulsed vacuum forces to increase the efficiency of aspiration thrombectomy. METHODS: Prospective, multicenter, open-label, core lab-adjudicated, two-arm study comparing safety and efficacy of a feasibility version of the RapidPulseTM system compared with contemporary controls. Primary endpoint was the rate of mTICI ≥ 2c after first-pass effect (FPE). Additional efficacy endpoints were the rates of mTICI ≥ 2b after first pass (modified FPE (mFPE)), last pass with study device defined as frontline technical success, and after all passes including rescue therapy. The primary safety endpoints included symptomatic ICH (sICH) within 24 h post-procedure. RESULTS: Between February 2022 to December 2022, 80 subjects were consented and enrolled in the study (n = 40 treatment arm, n = 40 control arm). In the intent to treat (ITT) population, mean age was 67.8 ± 11.5 years; 19 (47.5%) were male. Median NIHSS score was 16 (IQR: 13-22). Median ASPECTS score was 9 (IQR: 8-10). The rate of mTICI ≥ 2c after first pass was 53.9% in ITT population (60.0% in per-protocol population) versus 38.5% in the corresponding control population. Functional independence (mRS 0-2) at 90 days was achieved in 61.1% (22/36) in the RapidPulseTM arm and 52.8% (19/36) in the control arm. In the RapidPulseTM arm, no sICH within 24 h and no device-related morbidity or mortality occurred. CONCLUSION: Preliminary data suggests RapidPulseTM Aspiration System is highly effective and safe for recanalization of large vessel occlusions.

First pass results of mechanical thrombectomy with two-drop zone NeVaTM device.

BACKGROUND: Occlusive thrombi in acute ischemic stroke can be in various types which limits the success of the thrombectomy. The NeVaTM (Vesalio, Nashville, Tennessee) thrombectomy device was originally designed for all types of clot. Our aim was to evaluate the efficacy and safety of the NeVaTM device for mechanical thrombectomy. METHODS: Retrospective review of prospectively collected mechanical thrombectomy database revealed 145 patients who had fullfilled the inclusion criteria. The data collected includes clinical patient characteristics, procedural measures, timestamp at each stage, and patient outcome. IV thrombolytics application, pre and post-intervention imaging findings, device related adverse event and any type of intracranial hemorrhage were recorded. RESULTS: There was female pre-dominance (54.5%). Median presenting national institutes of health stroke scale (NIHSS) was 16 (IQR, 3-32). 88 MCA-m1 (60,6%), 43 ICA-tip (29,6%), 11 MCA-m2 (7,5%), 2 ACA (1,4%) and 1 basilar (0,7%) occlusions were underwent for mechanical thrombectomy. Median procedure time was 25 min (IQR, 7-136). First-pass reperfusion scores were mTICI 0-2a 22.7%, mTICI 2b 23.4%, mTICI 2c 17.9% and mTICI 3 35.9%. Mean number of pass was 1,84 ± 1,14. Final mTICI 2b-3 score was 97.9% and TICI2c-3 score was 87.6%. No device related adverse event occurred. The mean 24-h NIHSS score was 6 (IQR 0-33). CONCLUSION: In conclusion, the NeVa thrombectomy device offers a high rate of first-pass success along with favorable safety profile. Larger series and multi-center studies are needed for further investigation.

Radiofrequency-targeted vertebral augmentation for the treatment of vertebral compression fractures as a result of multiple myeloma.

STUDY DESIGN: A retrospective review of a consecutive population of patients treated with radiofrequency-targeted vertebral augmentation (RF-TVA) for malignant vertebral compression fractures (VCFs). OBJECTIVE: To investigate the safety and efficacy of RF-TVA in patients with malignant VCFs. SUMMARY OF BACKGROUND DATA: The use of polymethylmethacrylate (PMMA) in vertebroplasty and balloon kyphoplasty for patients with recalcitrant pain after acute VCFs is shown to be safe, successful in stabilizing the VCF, and effective for the relief of pain after osteoporotic and malignant VCFs. RF-TVA using targeted cavity creation and ultrahigh viscosity PMMA delivery with a long handling time was developed to address the potential adverse issues that arise with vertebroplasty and balloon kyphoplasty. METHODS: Between December 2008 and May 2009, a consecutive series of 66 RF-TVA procedures were performed by the authors for VCF secondary to multiple myeloma. Pre- and postoperatively, a standard 10-point visual analogue scale was used to assess back pain. Pain medication use and activity categories were defined and monitored for changes before and after RF-TVA. All patients were followed for 6 months postoperatively. RESULTS: At 6 months postoperatively, significant improvement in pain, activity, and narcotic use was observed. There were no pulmonary or neurological complications, and one patient had radiographical evidence of asymptomatic leakage of PMMA into the vertebral disc space. CONCLUSION: We report optimum safety and efficacy results in the treatment of malignant VCFs with a novel RF-TVA technique in which controlled delivery of an ultrahigh viscosity PMMA is used for fracture stabilization. The deposition of PMMA with RF-TVA is predictable and uniform, and can be performed without the PMMA handling constraints that may be encountered with vertebroplasty and balloon kyphoplasty. The safety and efficacy we report with RF-TVA achieved equivalency with other methods of treatment for VCF stabilization.

Transcatheter arterial embolization of a uterine artery pseudoaneurysm with Onyx® following D&C for uterine bleeding.

Transcatheter uterine artery embolization is well described and performed for treatment of symptomatic uterine leiomyomas, for postpartum hemorrhage, and for hemorrhage following hysterectomy. Embolic agents have included polyvinyl alcohol, gelfoam, coils, and Embospheres®. We present a case of severe uterine hemorrhage after a missed abortion (after two instances of dilatation and curettage), which could not be managed with traditional embolic techniques but was successfully controlled with Onyx®.

Successful intra-arterial thrombolytic therapy for a right middle cerebral artery stroke in a 2-year-old supported by a ventricular assist device.

Embolic stroke is a common complication in patients on ventricular assist devices in both adults and children. The reported incidence of strokes in children supported by VAD's varies from 7 to 38%. The rapid increase in recent years in the availability of both adult and pediatric VADs will likely add to the overall prevalence of strokes in patients being bridged to heart transplant. Strokes in this population can be lethal as they frequently necessitate withdrawal of the extracorporeal device support and withdrawal from the organ transplant waiting list. We present a case of a fully anti-coagulated 29-month-old supported on a Berlin EXCOR LVAD (Berlin, Germany) with embolic stroke which was treated successfully with direct thrombolysis with recombinant tissue plasminogen activator. This is the first report which uses intra-arterial thrombolytics while on a ventricular assist device in a pediatric patient.

Developmental venous anomaly coexisting with a true arteriovenous malformation: a rare clinical entity.

Two patients diagnosed with arteriovenous malformation (AVM) in close association with a developmental venous anomaly (DVA) are reported. The first patient presented with episodes of left extremity weakness and numbness as well as chronic headaches. The second patient presented with spontaneous intracerebral hemorrhage. Cerebral angiography showed that both the AVM and the transmedullary veins of the DVA drained through the transcortical vein. The AVMs were treated by highly selective transarterial embolization with Onyx embolic agent while preserving the DVAs. It is suggested that the cause of the presentation in both patients was secondary to the association of the AVM with the delicate hemodynamic balance and less robust angioarchitecture of the DVA.

Endovascular management of symptomatic vertebral artery origin stenosis in the presence of an acute thrombus.

A woman in her early 60s with hypertension and hyperlipidemia was undergoing investigations for anemia of unknown etiology. She developed a sudden reduction in visual acuity and bilateral visual field impairment. MRI and angiography revealed acute infarcts in the posterior circulation and severe narrowing of the left vertebral artery origin. Digital subtraction angiography demonstrated a high-grade stenosis of the left vertebral artery origin with a thrombus just distal to the stenosis. The patient developed recurrent infarcts while on antithrombotic therapy. The lesion was successfully treated by vertebral artery origin angioplasty and stenting (VOAS) using a flow reversal technique and distal embolic protection. She was discharged to a rehabilitation facility 4 days later without worsening or new neurological deficits. A search of the literature yielded a similar report managed with anticoagulation and subsequent VOAS after complete lysis of the thrombus. Our report highlights the technique, safety and feasibility of VOAS in the presence of a thrombus using a flow reversal technique and distal protection.

MRI-validation of SEP monitoring for ischemic events during microsurgical clipping of intracranial aneurysms.

OBJECTIVE: During surgical clipping of intracranial aneurysms, reduction in SEP amplitude is thought to indicate cortical ischemia and subsequent neurological deficits. Since the sensitivity of SEP is questioned, we investigated SEP with respect to post-operative ischemia. METHODS: In 36 patients with 51 intracranial aneurysms, clinical evaluation and diffusion-weighted MRI (DWI) was performed before and within 24h after surgery. During surgery, time of temporary occlusion was recorded. MRI images were reviewed for signs of ischemia. RESULTS: For 43 clip applications (84%), we observed neither pathologic SEP events nor ischemia in MRI. In two cases where reduction lasted >10 min after clip release, SEP events correlated with ischemia in the MRI. Only one of the ischemic patients was symptomatic and developed a transient hemiparesis. CONCLUSIONS: While pathologic SEP events correlated with visible ischemia in MRI only in two cases with late SEP recovery, ischemia in MRI may have been transient or may not have reached detection threshold in the other cases, in agreement with the absence of permanent neurological deficits. SIGNIFICANCE: In complex aneurysm cases, where prolonged temporary occlusion is expected, SEP should be used to detect ischemia at a reversible stage to improve the safety of aneurysm clipping.

The impact of minimizing brain retraction in aneurysm surgery: evaluation using magnetic resonance imaging.

BACKGROUND: Recent advances in skull base and microsurgical techniques minimize the need for brain retraction. OBJECTIVE: We studied the impact of such techniques in 36 patients (51 aneurysms) using magnetic resonance imaging (MRI). METHODS: Preoperative and 24 hours postoperative MR imaging was performed in patients undergoing microsurgical clipping of intracranial aneurysms. Images were evaluated for parenchymal signal changes. During surgery, use and time of brain retraction were recorded. The degree of cortical injury was quantified using a 0 to 3 scale (grade 0 = normal surface; 1 = pial/arachnoidal damage; 2 = gray matter injury; 3 = contusion/necrosis). RESULTS: Brain retraction by use of a brain spatula was used in all patients. Retraction times ranged from 14 to 290 minutes (mean, 84.1). Cortical surface changes were grade 0 in 86% and grade 1 in 14%; none showed grade 2 or 3 changes. In the postoperative MRI, 4 patients presented with parenchymal alterations, 4 with edema (11.1%), and 1 patient had additional contusion (2.8%). All lesions were confined to the temporal pole. The grade of cortical surface changes was not related to lesions found on MR imaging. No patients showed retraction-related neurological deficits. CONCLUSION: The incidence of evident mechanical parenchymal injury (infarction or contusion) is very low when appropriate microsurgical and skull base techniques are used. Minor pia-arachnoid injury should nevertheless continue to be attended through future advances.

Salvage percutaneous vertebral augmentation in failed spinal interbody fusions associated with multiple myeloma.

BACKGROUND CONTEXT: Failed posterior spinal interbody fusion is a known phenomenon with clinical consequences. PURPOSE: This technical note of percutaneous vertebral augmentation in patients with failed posterior interbody construct can be used in patients at high risk for repeat surgery, like patients with multiple myeloma. STUDY DESIGN/SETTING: Retrospective analysis of the two procedures was done. Clinical and radiologic follow-up was available for 1.5 years at the time of manuscript preparation. PATIENT SAMPLE: Both patients were referred to us after undergoing posterior spinal interbody fusion from outside institutions with persistent pain. The patients had a pain level requiring opioid analgesics and changes in the activities of daily living. The patients had active multiple myeloma at the time of the surgical intervention and vertebral augmentation procedure. OUTCOME MEASURES: Visual analog scales were used to gauge the pain relief after the procedure and during further follow-ups. In addition, radiologic follow-up was obtained by means of computed tomography and magnetic resonance imaging scans. METHODS: Vertebral augmentation procedures in both patients were done under intravenous conscious sedation with the patient prone. High-quality biplane fluoroscopy was used for the procedure. No immediate- or long-term complications were noted. RESULTS: Both patients had an appreciable relief from pain immediately after the procedure and on follow-up. Follow-up radiologic imaging revealed consistent cement distribution around the construct, no further collapse of the vertebra, with no new lucency surrounding the construct. CONCLUSIONS: This modified technique of vertebral augmentation can be helpful in management of cases with clinical or radiologic evidence of failed posterior spinal interbody fusion. The cage construct can be stabilized with the injection of cement. The cement surrounding the construct provides strength to the axis and prevents further loosening.

Symptomatic and silent ischemia associated with microsurgical clipping of intracranial aneurysms: evaluation with diffusion-weighted MRI.

BACKGROUND AND PURPOSE: Silent ischemic events are known to occur during diagnostic and interventional endovascular procedures between 10% and 69% of the time. The occurrence of silent and symptomatic ischemic events in the surgically treated population is not known, although atherosclerotic changes of intracranial vessels or within the aneurysms wall or neck area are seen often during surgery. METHODS: Patients with unruptured and ruptured intracranial aneurysms treated by microsurgical clipping were prospectively evaluated with MRI using diffusion-weighted imaging sequences before and within 24 hours after surgery. Patients were evaluated clinically before and after surgery. During surgery, the overall and maximal time of temporary occlusion as well as the total number of temporary and finally applied clips was noted. Diffusion-weighted images were analyzed with determination and characterization of diffusion-weighted imaging abnormalities. RESULTS: Thirty-six patients with 51 aneurysms were included. One symptomatic and 5 silent ischemic lesions were found in 5 patients. This represents a risk of silent ischemia of 9.8% per treated aneurysm and a risk of symptomatic stroke of 2%. The most significant risk factor in increasing order was: age (P<0.05), presence of thrombus (P<0.05), number of final clips applied (P<0.05), number of temporary clips used (P<0.01), total time of temporary clip occlusion (P<0.001), and maximal time of temporary occlusion (P<0.001). CONCLUSIONS: The risk of silent and symptomatic ischemic events during microsurgical clipping of intracranial aneurysms seems to be low. Microsurgical clipping is safe and should continue to be strongly considered as a treatment option.

Arteriovenous fistula originating from proximal part of the anterior cerebral artery.

Intracerebral arteriovenous fistulas of the brain may be misdiagnosed as arteriovenous malformation. There are only a few reports in the literature about this concept and to the best of our knowledge this is the first case arising from the proximal part of the anterior cerebral artery in association with an aneurysm that ruptured. A 64-year-old man presented with subarachnoid hemorrhage. The patient was neurologically intact. Cerebral angiography and magnetic resonance imaging of the patient revealed a small arteriovenous malformation of the brain involving the region of gyrus rectus and the posteromedial aspect of the orbitofrontal gyrus in addition to an aneurysmal dilatation within the malformation. An arteriovenous fistula arising from the junction of the A1 and A2 segments of the right anterior cerebral artery connected to a vein that has tributaries spreading over the fronto-orbital gyrus and gyrus rectus, were observed during surgery. The patient was successfully treated with clip ligatation of the fistula. Intracerebral arteriovenous fistulas are rare lesions. They may easily be misdiagnosed as arteriovenous malformations. There preoperative consideration in the differential diagnosis can help to decide the most appropriate treatment option.

Selective intracranial magnification angiography of the rabbit: basic techniques and anatomy.

Development of new therapies for stroke requires animal models with well-defined intracranial vasculature. The rabbit as a small animal model has many desirable traits; however, a modern atlas of rabbit angiographic anatomy is not readily available. Improved digital subtraction magnification angiography and superselective small-catheter techniques now allow excellent anatomical definition. Angiographic techniques include selection of the internal carotid artery and subselection with microcatheters that can progress to branches of the circle of Willis and provide high-resolution cerebral angiography. The authors present an overview of current techniques and illustrations of the angiography of cerebral vessels.

Magnetic resonance imaging in multiple myeloma: diagnostic and clinical implications.

PURPOSE: Magnetic resonance imaging (MRI) permits the detection of diffuse and focal bone marrow infiltration in the absence of osteopenia or focal osteolysis on standard metastatic bone surveys (MBSs). PATIENTS AND METHODS: Both baseline MBS and MRI were available in 611 of 668 myeloma patients who were treated uniformly with a tandem autologous transplantation-based protocol and were evaluated to determine their respective merits for disease staging, response assessment, and outcome prediction. RESULTS: MRI detected focal lesions (FLs) in 74% and MBS in 56% of imaged anatomic sites; 52% of 267 patients with normal MBS results and 20% of 160 with normal MRI results had FL on MRI and MBS, respectively. MRI- but not MBS-defined FL independently affected survival. Cytogenetic abnormalities (CAs) and more than seven FLs on MRI (MRI-FLs) distinguished three risk groups: 5-year survival was 76% in the absence of both more than seven MRI-FLs and CA (n = 276), 61% in the presence of one MRI-FL (n = 262), and 37% in the presence of both unfavorable parameters (n = 67). MRI-FL correlated with low albumin and elevated levels of C-reactive protein, lactate dehydrogenase, and creatinine, but did not correlate with age, beta-2-microglobulin, and CA. Resolution of MRI-FL, occurring in 60% of cases and not seen with MBS-defined FL, conferred superior survival. CONCLUSION: MRI is a more powerful tool for detection of FLs than is MBS. MRI-FL number had independent prognostic implications; additionally, MRI-FL resolution identified a subgroup with superior survival. We therefore recommend that, in addition to MBS, MRI be used routinely for staging, prognosis, and response assessment in myeloma.

Esophageal stent erosion into the common carotid artery.

A pseudoaneurysm of the common carotid artery was found with computed tomography in a 62-year-old woman with an esophageal stent that had eroded through her skin. The pseudoaneurysm was treated with a self-expanding nitinol stent; after massive hemoptysis, an endograft was placed on the pseudoaneurysm. The patient then underwent ligation of the left common carotid artery, proximal to the carotid bulb, and excision of the endograft and previously placed coils. The esophageal stent wires were so that they could no longer impinge the common carotid artery.

Superior ophthalmic vein approach to carotid-cavernous fistulas. Technical note.

Endovascular procedures have revolutionized the treatment of carotid-cavernous fistulas through transarterial and transvenous routes. In some circumstances, however, traditional endovascular approaches may fail. Direct access to the superior ophthalmic vein (SOV) can be used to treat fistulas in this circumstance. The authors discuss the technical aspects of direct exposure of the SOV for access to the cavernous sinus.