RESUMO
The authors performed a study in 14 top weightlifters, in order to make evident some effects of inosine. The athletes of A group received daily 1.5 g inosine (3 x 500 mg) for 6 weeks while the athletes of the B group (control group) received placebo. Six weeks inosine treatment induced significant changes for serum lipids and FFA (increase), urine mucoproteins (decrease), evoked muscular potential for the right median nerve and motric speed conductibility of the right external sciaticus popliteus nerve; the activity of serum CPK also increased. Some of these changes (CPK, evoked muscular potential, urine mucoproteins etc.) were evident even after 3 weeks of treatment.
Assuntos
Inosina/farmacologia , Resistência Física , Levantamento de Peso , Adolescente , Adulto , Creatina Quinase/sangue , Potenciais Evocados/efeitos dos fármacos , Humanos , Lipídeos/sangue , Nervo Mediano/fisiologia , Mucoproteínas/urina , Condução Nervosa/efeitos dos fármacos , Nervo Isquiático/fisiologiaRESUMO
Chronic and acute effects of L-Carnitina (vials of 1 g L-Carnitina endovenous; per orally administered vials of 1 g L-Carnitina; tablets of 1 g L-Carnitina) were recorded in 110 top athletes (rowing, kayak-canoe, swimming, weightlifting medium and long-distance runners), 47 girls and 63 boys, by six double blind placebo trials and cross over. Significant changes were registered after L-Carnitina treatment (both for a single dose or after 3 weeks of treatment) compared to placebo, for FFA, triglycenides, lactic acid after exercise, evoked muscular potential, plasma carnitine (free and acetyl-carnitine), urine carnitine (free carnitine) and others. The authors explain these changes by the increase of free carnitine, which permits a larger quantity of FFA to enter the mitochondria and to be more extensively used as energy source in endurance and strength efforts. Based on these results the authors recommend L-Carnitina as an ergogenic aid in elite athletes, especially in endurance and strength sports.
Assuntos
Carnitina/farmacologia , Esportes , Adolescente , Adulto , Carnitina/sangue , Carnitina/urina , Potenciais Evocados/fisiologia , Ácidos Graxos não Esterificados/sangue , Feminino , Humanos , Cinética , Lactatos/sangue , Ácido Láctico , Masculino , Mucoproteínas/urina , Músculos/fisiologia , Esforço Físico/fisiologia , Triglicerídeos/sangueRESUMO
Acute effects of l-carnitine (vials of 1 g endovenous) were recorded in a group of elite athletes (17 swimmers) by a prospective double-blind placebo-controlled trial and cross over. Significant changes were registered after l-carnitine injection, compared to placebo, for FFA, triglycerides, lactic acid after exercise, evoked muscular potential, 90 to 120 minutes after injection. The authors explain these changes by the increase of free carnitine, which permits a larger quantity of FFA to enter the mitochondria and to be more extensively used as energy source.
