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1.
J R Coll Surg Edinb ; 44(6): 352-61, 1999 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-10612956

RESUMO

In this article the basic biology and function of fatty acids (FAs) will be reviewed. The literature relating to FAs and prostate cancer will be evaluated and possible mechanisms for the mode of action of FAs in the carcinogenesis and progression of prostate cancer will be discussed. In addition, the potential role for specific FAs in the treatment and prevention of prostate cancer will be assessed.


Assuntos
Ácidos Graxos/fisiologia , Neoplasias da Próstata , Animais , Apoptose , Transformação Celular Neoplásica/patologia , Progressão da Doença , Ácidos Graxos/metabolismo , Humanos , Peroxidação de Lipídeos , Masculino , Neoplasias da Próstata/patologia , Neoplasias da Próstata/prevenção & controle , Neoplasias da Próstata/terapia
2.
J R Coll Surg Edinb ; 43(3): 163-8, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9654876

RESUMO

Various prognostic factors for survival have been identified in patients with colorectal cancer. However, although it has been suggested that the pre-treatment serum albumin concentration is a prognostic indicator in certain malignant diseases (melanoma, prostate cancer, leukaemia), its value in patients with colorectal cancer remains unclear. This study investigated the prognostic value of serum albumin in this patient group. A total of 431 patients presenting to the Professorial Surgical Unit between 1972 and 1985 were analysed in this study. Using the Cox proportional hazard model, age, tumour stage (Dukes' stage) and tumour differentiation were shown to be independent prognostic factors for survival in patients with localized colorectal cancer. In addition, the pre-treatment serum albumin concentration was found to be an independent prognostic indicator. This is the first such documentation for patients with 'curable' colorectal cancer.


Assuntos
Biomarcadores Tumorais/análise , Neoplasias Colorretais/sangue , Neoplasias Colorretais/diagnóstico , Albumina Sérica/análise , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Colorretais/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Modelos de Riscos Proporcionais , Sensibilidade e Especificidade , Taxa de Sobrevida
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