[Biochemical and ultrastructural changes in the periodontium during the chronic administration of pro-oxidant xenobiotics]. / Biokhimicheskie i ul'trastrukturnye izmeneniia v parodonte pri khronicheskom vvedenii ksenobiotikov-prooksidantov.

Effects of chronic administration of xenobiotics pro-oxidants on the state of periodontal tissues, level of free-radical oxidation of lipids, and antioxidant provision were studied. Diphenin and delagil were found to promote biochemical and morphological changes similar to the manifestations observed in periodontitis. A conclusion is made about an important role of nonenzymatic free-radical oxidation of lipids and biopolymers in the pathogenesis of periodontitis. The principal stages of contribution of autooxidation to the parodontogenesis are presented.