[Comparative effectiveness of current pathogenetic methods of treating neurodermatitis]. / Sravnitel'naia éffektivnost' sovremennykh patogeneticheskikh metodov lecheniia neirodermita.

The authors compare various present-day pathogenetic methods used in the treatment of 258 patients with disseminated neurodermatitis (81 cases with the atopic form and 177 ones with the nonatopic form). Clinical and laboratory studies have demonstrated the efficacy of adrenoblockers, pyrroxan and butyroxan, included in multiple-modality therapy for patients with manifest disorders of the autonomic nervous system. Combinations of glycyrrham and voltaren and decimetric wave exposure of the adrenal area have been also effective, as well as parmidine, an antibradykinin drug, in a daily dose of 2.0 g. In the most severe and stubborn cases corticosteroids may be administered; the schemes of therapy should be sparing and physiological, with the drugs given every other day, this helping reduce the total dose of the drug.

[The role of various classes of catecholamines in the central regulation of the hypothalamo-hypophyseo-adrenal cortex system]. / Rol' katekholaminov razlichnykh klassov v tsentral'noi reguliatsii gipotalamo-gipofizarno-adrenokortikal'noi sistemy.

Adrenaline, norepinephrine and dopamine were stereotaxically administered into mediobasal hypothalamus of rats. The data obtained revealed an activating catecholamine effect on the hypothalamo-hypophyseal-adrenal system (HHAS). The most obvious activating effect on the hormonal status of HHAS was characteristic of norepinephrine, less pronounced was the effect of "stress" doses of adrenaline and dopamine, the aforementioned effect was insignificant with dopamine in physiological concentration.

[Phases of the initial reaction of the sympatho-adrenal system to stress]. / Fazy pervichnoi reaktsii simpatiko-adrenalovoi sistemy na stress.

Changes in the content and ratio of catecholamines, their precursors and metabolites in canine blood and tissues during the initial period of stress have been studied. A sharp increase in tissue adrenaline (A) and dopamine (DA) and a decrease in tissue noradrenaline (NA); decline in blood A and rise in blood NA; inhibition of monoamine oxidase activity and a fall in metanephrine and normetanephrine blood and tissue level have been demonstrated in the first phase of reaction developing right after exposure to stress. A sharp synchronous rise in A, NA and DA and a parallel increase in their metabolic intensity towards oxidative deamination and O-methylation have been found in the second phase of reaction that develops in 60 sec. The first phase of the reaction has been designated as dissociation phase of sympathoadrenal secretory synthetic activity, and the second phase was termed the phase of synchronous system activation.

[Electrophysiological and catecholamine mechanisms of negative feedback in regulation of the hypothalamus by male sex glands]. / Elektrofiziologicheskie i katekholaminovye mekhanizymy otritsatel'noi obratnoi sviazi v gipotalamicheskoi reguliatsii muzhskimi polovymi zhelezami.

The immediate response on the part of the sympathoadrenal system (SAS) in mature male rats to testosterone propionate involves an increase in the content of dopamine and lowering of adrenaline and noradrenaline content in the hypothalamus, brain cortex, adrenals and peripheral organs, paralleled by an increase in the amplitude of evoked potentials and reduction in the frequency of induced impulse activity of arcuate neurons of the hypothalamus. This attests to the specificity of the associated response of the SAS and the hypothalamus-pituitary-gonadal system (HPGS) to hyperandrogenization and to the dopaminergic nature of the negative feed-back mechanism in the HPGS.

[Primary response mechanisms of the adrenal cortex in dogs to pain stress]. / O mekhanizmakh pervichnogo otveta kory nadpochechnikov sobak na bolevoi stress.

The adrenal cortex of dogs shows a drop in the glucocorticoid content 10--15 sec after the pain action in the presence of the free cholesterol level increase and its esterified form drop. The concentrations of hormones in the blood falls chiefly at the expense of protein bound hydrocortisone. The subsequent phase of the reaction (after 30--60 sec) is characterized by a considerable accumulation of the hormones by the gland. The level of free glucocorticoids significantly increases, the initial ratio of hydrocortisone and cortisone restores, and transcortin depot is filled up. The role of the adrenal and transcortine depot in realization of feedback mechanisms under stress is discussed.