RESUMO
The cavernous hemangiomas of the liver are usually small sized and asymptomatic. Most of them are incidentally diagnosed and a very small portion requires therapy. Giant hemangioma can be symptomatic, and this condition is the indication for treatment. The striking complication of surgical treatment of cavernous hemangiomas is intra-operative bleeding. In this case, we aimed to demonstrate that the risk of intraoperative bleeding can be eliminated with the preoperative percutaneous trans-catheter arterial embolization technique.
Assuntos
Embolização Terapêutica , Hemangioma Cavernoso/cirurgia , Neoplasias Hepáticas/cirurgia , Adulto , Perda Sanguínea Cirúrgica/prevenção & controle , Feminino , Hemangioma Cavernoso/irrigação sanguínea , Humanos , Neoplasias Hepáticas/irrigação sanguínea , Cuidados Pré-OperatóriosRESUMO
Organophosphorus insecticides are used worldwide in the control of agricultural, household and veterinary pests. Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is a commonly used organophosphorus insecticide. In this study, in order to elucidate the toxic nuclear effects of dichlorvos, freshly isolated human peripheral blood lymphocytes were incubated with 5, 10, 20, 40, 80 and 100 microg/mL of dichlorvos. According to the results, dichlorvos induced micronuclei, decreased the mitotic and replication indexes. It is a genotoxic product causing chromosomal damage (an increase in micronucleus) and cell death (decrease in mitotic and replication indexes).
Assuntos
Núcleo Celular/efeitos dos fármacos , Núcleo Celular/patologia , Diclorvós/farmacologia , Inseticidas/farmacologia , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/patologia , Morte Celular/efeitos dos fármacos , Divisão Celular/efeitos dos fármacos , Células Cultivadas , Cromossomos/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Mitose/efeitos dos fármacosRESUMO
Propolis is a natural product that is collected by the honeybee (Apis mellifera L.) from plants. The in vitro genotoxic potential of propolis in human lymphocytes was investigated. Blood samples were obtained from ten healthy (five female and five male), non-smoking and alcohol volunteers, which were incubated and exposed to increasing concentrations of propolis (5, 25, 50 and 250 mg/ml). The mean sister chromatid exchange (SCE) rates were 10.398 +/- 1.47-21.522 +/- 2.08. The differences between the control and exposed cells were statistically significant (p < 0.05). Increasing SCE rates showed that propolis could have genotoxic effects in high concentrations. SCE rates of women donors exceeded those of men donors. Women donors had the highest SCE rates (25.674 +/- 8.71, 22.456 +/- 7.97 and 15.756 +/- 5.09 for mean of SCE).
