1.
Org Biomol Chem
; 21(2): 345-350, 2023 01 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36484719
RESUMO
A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtained in moderate to excellent yields and with high enantioselectivities. The stereochemical outcome of the reaction has been explained by DFT calculations.