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J Proteomics ; 72(2): 183-99, 2009 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-19457345

RESUMO

This communication revises the state of the art concerning antivenoms against snakes, spiders and scorpions. An overview of the historical facts that preceded the therapeutic use of antibodies is mentioned. A brief list of the major protein components of these venomous animals is revised with a short discussion of what is known on the proteomic analysis of their venoms, but the emphasis is placed on the type of antivenoms available commercially, including pertinent literature and addresses of the companies that prepare these antivenoms. The final section revises and discusses current research on the field and new potential applications that are being developed geared at obtaining new therapeutic antibodies or fragments of antibodies for neutralization of toxic components of venomous animals.


Assuntos
Antivenenos/análise , Proteômica/métodos , Venenos de Escorpião/toxicidade , Venenos de Serpentes/toxicidade , Venenos de Aranha/toxicidade , Animais , Antivenenos/imunologia , Cromatografia Líquida de Alta Pressão , Humanos , Imunoglobulina G/química , Camundongos , Proteoma , Proteínas Recombinantes/química , Venenos de Escorpião/análise , Escorpiões , Venenos de Serpentes/análise , Venenos de Aranha/análise , Aranhas
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