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BMJ Case Rep ; 20182018 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-29477994

RESUMO

Acute endocapillary glomerulonephritis, as its name suggests, is a one-time process, which usually resolves within weeks. However, in a small percentage of patients, the disease becomes chronic. In these cases, a deregulation in the alternative complement pathway, which can be caused by mutations or autoantibodies, has been proposed as a pathophysiological mechanism. As a result, the alternative complement pathway remains active after resolution of infection. We report a patient with two episodes of acute renal failure, both times diagnosed by renal biopsy of acute endocapillary glomerulonephritis, with slow recovery after two episodes of low-serum complement C3, haematuria and proteinuria.


Assuntos
Complemento C3/imunologia , Glomerulonefrite/complicações , Glomerulonefrite/imunologia , Infecções/complicações , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/imunologia , Injúria Renal Aguda/patologia , Idoso , Biópsia , Via Alternativa do Complemento/imunologia , Glomerulonefrite/patologia , Humanos , Infecções/imunologia , Rim/imunologia , Rim/patologia , Masculino , Recidiva
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