RESUMO
BACKGROUND: The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria. METHODS: To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used. RESULTS: The root bark extract of I. senegalensis (50, 100, and 200 mg/kg) exhibited a significant (p<0.05) dose-dependent activity against the parasite based on suppressive and curative study. The antimalarial effect of I. senegalensis is compared with that of chloroquine (10 mg/kg), the standard drug. The ethanolic root bark extract also prolonged the survival time of infected mice. CONCLUSIONS: The results showed that the root bark extract possesses a potential antiplasmodial activity, which can be exploited for the possible development of new antimalarial agent.
Assuntos
Antimaláricos/uso terapêutico , Malária/tratamento farmacológico , Casca de Planta , Extratos Vegetais/uso terapêutico , Plasmodium berghei/efeitos dos fármacos , Animais , Antimaláricos/isolamento & purificação , Antimaláricos/farmacologia , Relação Dose-Resposta a Droga , Etanol/farmacologia , Etanol/uso terapêutico , Feminino , Malária/patologia , Masculino , Camundongos , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Plasmodium berghei/fisiologiaRESUMO
Objective: To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis. Methods: The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control. Results: A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time. Conclusions: The results support further investigation on components of traditional medicines as potential new antimalarial agents.
RESUMO
OBJECTIVE@#To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis.@*METHODS@#The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control.@*RESULTS@#A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time.@*CONCLUSIONS@#The results support further investigation on components of traditional medicines as potential new antimalarial agents.
RESUMO
OBJECTIVE@#To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.@*METHODS@#The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.@*RESULTS@#The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).@*CONCLUSIONS@#The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
