Glutathione and cysteine levels in human tumour biopsies.

There is evidence that some human tumours could be treated with a combination of buthionine sulfoximine and hypoxic cell sensitizers. However, clinical application of this technique requires a prior knowledge of the level of non-protein bound sulfhydryl (NPSH) compounds in these tumours. The present study provides data on the levels of glutathione (GSH) and cysteine (CYS) in human tumour biopsies from the cervix and from the head and neck. The NPSH compounds were measured by high performance liquid chromatography. The median GSH values were 20.5 nmol/mg protein (cervix) and 23 nmol/mg protein (head and neck) while the median CYS values were 4.4 (cervix) and 4.2 nmol/mg protein (head and neck). The values varied widely from one patient to another.

[Nasal chondroma associated with Ollier's disease. Apropos of a case observed at the Gustave-Roussy Institute]. / Chondrome nasal associé à une maladie d'Ollier. A propos d'un cas observé à l'Institut Gustave-Roussy.

A patient with a nasal chondroma and Ollier's disease treated at the Institut Gustave-Roussy, Villejuif, had a long past medical history of over 10 years, starting with a nasal lesion diagnosed as a myxoma. Follow up clinical and radiologic examinations failed to detect recurrences. The discovery, ten years after excision of tumor, of multiple skeletal enchondromas raised the hypothesis of Ollier's disease, this being responsible for the myxoid chondroma of the nasal cavities. A past medical history of surgery to the left lower limb presenting a valgus deformity, and of a left suborbital angioma treated by curietherapy confirmed the diagnosis of Ollier's disease and suggested that of a Maffuci syndrome. Prognosis of the disease is dominated by the risk of onset of chondrosarcoma.