Assessment of Knowledge, Attitudes, and Practices (KAP): Public Health and Economic Burden of Tuberculosis in Jarso District of West Wollega Zone, Oromia, Western Ethiopia.

Tuberculosis is a communicable mycobacterial disease of humans and animals caused by members of Mycobacterium tuberculosis complex, highly impacting the public health and economy of the country in endemic areas. Retrospective and cross-sectional study was conducted between March and August 2021. For knowledge, attitude, and practices study, five villages were randomly selected using simple random sampling. To quantify the public health burden, one-year data were collected from Jarso Health Center, and unregistered patients were identified using snowball method, and the estimation was based on disability-adjusted life years. Younger age groups (18-40 years) had shown 105.8 times more odds of knowledge towards tuberculosis than the older (>60 years). Moreover, tertiary levels of education had 9395.1 times more odds of knowledge towards tuberculosis compared to illiterates. The estimated economic burden was 7,731.25US$. Of the 51 tuberculosis patients, two died from the disease, resulting in 45.03 disability-adjusted life years. Communities of the study district were heard about tuberculosis, however, unaware of the cause and sources of the infection. Therefore, further strategic and continuous community-based health education and awareness should be given for effective control and prevention of tuberculosis in the study area.

Cross-Sectional Study of Seroprevalence and Associated Risk Factors of Bovine Brucellosis in Selected Districts of Jimma Zone, South Western Oromia, Ethiopia.

Bovine brucellosis is one of the most widespread but neglected zoonotic diseases in developing countries where it is an endemic and growing problem causing public health impacts. Developing a cost-effective control strategy of the disease can only be guaranteed by knowledge of the disease epidemiology that defines its risk profiles. Hence, this study was designed to evaluate epidemiological aspects of bovine brucellosis in selected districts of Jimma zone. A cross-sectional study with multistage sampling techniques was conducted on 424 cattle to evaluate its seroprevalence. Likewise, 114 households were included for the investigation of risk factors. SPSS version 20 for data analysis and C-ELISA test for antibody detection were used. Moreover, the chi-square test for univariable analysis and logistic regression model for multivariable analysis were employed to assess association between seropositivity and risk factors. From this study, 3.3% (95% CI: 1.82-5.48) and 12.3% (95% CI: 6.88-19.75) seroprevalence of the disease was detected with the highest proportion found at Kersa district (6.5 (95% CI: 1.37-17.90) and (21.4 (95% CI: 4.66-50.80)) followed by Seka Chokorsa (1.76 (95% CI: 0.37-5.07) and (6.7 (95% CI: 1.40-18.27)) and Mana (1.75 (95% CI: 0.21-6.20) and (7.1 (95% CI: 0.88-23.50)) at individual animals and herd levels, respectively. Cattle of poor body condition, pregnant, and cows with history of abortion and repeat breeding were found 4.8 (95% CI: 2.00-22.74), 4.3 (95% CI: 1.43-13.04), 3.3 (95% CI: 1.07-10.21), and 2.7 (95% CI: 1.86-8.15) times more likely seropositive than their counterparts, respectively. Besides these, mixed feeding style was highly associated with seropositive reactors than separate feeding (AOR = 8.3; 95% CI: 1.76-38.99). These findings depicted substantial areas to be addressed in implementation of appropriate and immediate control actions and establishment of intervention mechanisms of bovine brucellosis.

Veterinary Drug Prescribing Practices at Selected District Veterinary Clinics of Rift Valley Areas of Ethiopia.

The rational use of drugs in veterinary medicine has various significances, such as reducing the risk of drug resistance, increasing efficacy, reducing drug residue, and decreasing adverse drug reactions. A retrospective study was conducted to assess veterinary drug prescribing practices at Batu and Arsi-Negelle district veterinary clinics in the rift valley areas of Ethiopia. A total of 2,464 cases were recorded from the case registration books at both the clinics for diseases treated between September 2012 and February 2015. The study results showed that for a total of 2,464 cases diagnosed at both clinics, 3,811 different drugs were prescribed, with an average per encounter of 1.6. Among the total drugs, oxytetracycline, ivermectin, penstrep, sulfa drugs, and albendazole were the most leading prescribed drugs with a frequency of 43.0%, 17.6%, 10.2%, 6.5%, and 1.3%, respectively. All drugs were prescribed by the generic name without any laboratory support of the disease. About 68.3% of the cases were diagnosed by unspecified professionals, whereas 21.7% and 10.1% were done by animal health assistants and veterinarians, respectively. The prescribing practices showed 61.0% of antibiotics and 29.7% of anthelmintics where 45.3% and 54.7% of antibiotics and 17.8% and 82.2% of anthelmintics were given at Batu and Arsi-Negelle veterinary clinics, respectively. Of the prescribed drugs, 4.6% oxytetracycline and 2.6% penstrep were prescribed irrationally to treat diseases that were tentatively diagnosed as parasitic cases. Similarly, 40.5% ivermectin and 17.7% albendazole were prescribed for bacterial infections. In conclusion, this study revealed problems in antibiotics and anthelmintics use, description of routes of administration and length of treatment, and shortage of laboratory diagnostic facilities. Therefore, veterinary drugs, particularly antibiotics and anthelmintics, should be used appropriately to safeguard the public from residual drug impacts and resistance development.