Qualitative analysis of the male experience of heart failure.

OBJECTIVE: The purpose of this study was to gain insight from the patient's perspective into how it is to live with moderate chronic heart failure (HF). METHODS: Twenty men with moderate chronic HF in New York Heart Association classes II to III, aged 43 to 73 years, were interviewed with open-ended questions. The interviews were analyzed using qualitative inductive content analysis as a method. RESULTS: Both the consequences of the illness and how the patients adjusted to them were described in the narratives. The consequences were physical, emotional, cognitive, social, and vocational and included thoughts about death. Adjusting to the illness involved changing one's lifestyle, being aware of one's physical ability and disability, developing psychologic strategies, and adjusting to medication. CONCLUSIONS: The findings of this study demonstrate a wider range of disabilities as a consequence of moderate chronic HF and show several more ways of adjusting to the illness than previously reported in men.

Long-term clearance from small airways in patients with chronic bronchitis: experimental and theoretical data.

Long-term clearance (21 days) from small airways was studied in 9 patients with chronic bronchitis (CB), 65 +/- 10 (mean +/- SD) years, and was compared to 15 age-matched healthy subjects of 67 +/- 7 (mean +/- SD) years. Six of the CB patients were studied twice. All subjects inhaled monodisperse 6 microm Teflon particles labelled with 111In with an extremely slow inhalation flow, 0.05 L/s. With this inhalation technique, particles are deposited mainly in the small conducting airways. Lung retention was measured at 0 and 24 hours, and at 7, 14, and 21 days after inhalation. Lung retention at 24 hours (% of deposition) was highly reproducible for the CB patients, studied twice, but it was not significantly different from that found for healthy subjects and, furthermore, not related to airway resistance (Raw), nor FEV1% predicted. Both healthy subjects and CB patients showed significant clearance in the period between 24 hours and day 21. The mean retention were higher (P<.001) in CB patients, 90%, 89%, 87% of 24 hours retention at 7, 14, and 21 days, compared to 80%, 76%, 71% of 24 hours retention at 7, 14, and 21 days measurements for healthy subjects. Clearance after 24 hours (retention at 21 days) was significantly related to FEV1% predicted, but not Raw. Reduced FEV1% predicted values was associated with slower clearance rates. Model calculations were performed to estimate intrapulmonary deposition patterns. A limited effect was shown for airway dimension and uneven ventilation. The differences between healthy and CB patients were, however, limited. It is not possible to conclude whether the difference in clearance after 24 hours is an effect of change in regional deposition, or slower small airway clearance in diseased airways. This technique to target the smallest ciliated airways, using an extremely slow inhalation flow, provides new possibilities to investigate smallest airway function and drug delivery that merits further investigations.