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J Endourol ; 33(4): 337-342, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30793930

RESUMO

INTRODUCTION: Renal papillary pits are commonly encountered during ureteroscopy. The mechanism by which such pits arise is unclear. One hypothesis is that pits represent sites where stones overgrowing Randall's plaque (RP) were dislodged. We sought to examine this theory by using digital ureteroscopy and stone µCT. MATERIALS AND METHODS: Patients undergoing endoscopic stone removal had procedures recorded and stones analyzed by using µCT. Stones with evidence of Randall's plaque anchors (RPAs) were identified in a blinded fashion. Surgical videos were reviewed independently by two urologists. RESULTS: Twenty-eight patients had µCT-confirmed stones with RPA. Among them, 93% were recurrent stone formers and 75% had had prior stone procedures. Metabolic abnormalities were present in 87%, with 79% classified as idiopathic calcium oxalate stone formers. A mean of 7.6 stones with RPA were identified per procedure. In each case, papillary pits were visualized before any stone manipulation and in several cases the active dislodgement of an attached stone led to immediate identification of an underlying pit. Such stones routinely demonstrated an RPA on µCT. The average depth of RPA was 302 ± 172 µm, consistent with the corresponding shallow pits visualized on the papillary surface. CONCLUSIONS: Stones overgrowing RP are capable of pulling away a piece of papilla when dislodged, resulting in a visible papillary pit. This process manifests as an RPA on the undersurface of the stone and a papillary pit on the corresponding area of attachment. Identification of pits may help identify patients who form stones primarily by the RP mechanism.


Assuntos
Cálculos Renais/cirurgia , Medula Renal/cirurgia , Rim/cirurgia , Ureteroscopia/métodos , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Rim/diagnóstico por imagem , Cálculos Renais/diagnóstico por imagem , Medula Renal/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Medição de Risco , Urologistas , Microtomografia por Raio-X , Adulto Jovem
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