RESUMO
A 39-year-old man had meningitis, which subsequently proved to be due to Neisseria gonorrhoeae. This report describes the second known case of primary gonococcal meningitis. This disease mimics meningococcal meningitis closely, and the diagnosis can only be made by careful bacteriologic study.
Assuntos
Líquido Cefalorraquidiano/microbiologia , Gonorreia/microbiologia , Meningite/microbiologia , Neisseria gonorrhoeae/isolamento & purificação , Adulto , Humanos , MasculinoRESUMO
We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.
Assuntos
Antígenos Glicosídicos Associados a Tumores , Autoanticorpos/análise , Dissacarídeos/imunologia , Gangliosídeo G(M1)/imunologia , Gangliosídeos/imunologia , Imunoglobulina M/análise , Imunoterapia , Neurônios Motores/imunologia , Doenças Neuromusculares/imunologia , Adulto , Cromatografia Líquida de Alta Pressão/métodos , Ensaio de Imunoadsorção Enzimática , Humanos , Masculino , Doenças Neuromusculares/terapiaRESUMO
Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM1 in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.
Assuntos
Autoanticorpos/sangue , Gangliosídeo G(M1)/imunologia , Gangliosídeos/imunologia , Neurônios Motores/metabolismo , Doenças Neuromusculares/imunologia , Feminino , Humanos , Cadeias mu de Imunoglobulina , Masculino , Pessoa de Meia-IdadeRESUMO
Technetium-99m Pseudogas is an ultrafine near monodisperse aerosol of 0.12-microgram diam particle size. This report describes initial clinical experiences with 27 patients referred for investigation of suspected pulmonary embolism, and in whom Pseudogas ventilation images were compared with a high quality commercial aerosol. An additional group of ten patients with severe COPD was examined in a comparative trial of Pseudogas with 81mKr. Pseudogas was better than a conventional aerosol in reaching a diagnosis of pulmonary embolism using a simple blinded comparison with coded images. In addition, bronchial deposition was minimal unless COPD was severe. Moderately well patients had no difficulty inhaling the necessary activity in one or two breaths, and even severely ill and frail aged persons could accomplish the passive breathing maneuver in less than a minute. Clearance of Pseudogas was directly to the systemic circulation with a half-time of 10 min in normal subjects extending up to 100 min in patients with airways disease.