RESUMO
Clinical efficacy of intravenous gentamicin in combination with oral use of gentamicin, ristomycin and nystatin was studied in 1977. In 1980-1984 two antiinfectious regimens were tested: intravenous administration of gentamicin in combination with total decontamination (oral use of gentamicin and nystatin) and selective decontamination (biseptol with nystatin of amphoglucamine). It was shown that the incidence of severe infections in the patients under the observation dropped against the controls. The incidence and spectrum of infectious complications in cases with acute myelodepressions were proved to depend on the intestinal autoflora inhibition.
Assuntos
Antibacterianos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Infecções por Enterobacteriaceae/prevenção & controle , Enterobacteriaceae/efeitos dos fármacos , Intestinos/microbiologia , Leucemia/tratamento farmacológico , Síndromes Mielodisplásicas/complicações , Infecções Oportunistas/prevenção & controle , Esterilização/métodos , Doença Aguda , Administração Oral , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Humanos , Injeções Intravenosas , Intestinos/efeitos dos fármacos , Leucemia/complicações , Síndromes Mielodisplásicas/induzido quimicamenteRESUMO
The previous experience gained with the treatment of acute radiation sickness supported during the treatment of the victims to the disaster at the Chernobyl NPP has shown the multimodality treatment to be indispensable for the bone marrow syndrome, particularly in terms of correcting postradiation thrombocytopenia and counteracting bleeding sickness. The use of the whole blood was found to be inadvisable because of the low efficacy, with the risk of transfusion complications being fairly high. Adequate replacement therapy with donor's platelets is capable of a complete modifying of the hemorrhagic syndrome.
Assuntos
Transfusão de Componentes Sanguíneos , Lesões por Radiação/terapia , Acidentes , Doença Aguda , Transfusão de Componentes Sanguíneos/métodos , Terapia Combinada , Humanos , Reatores Nucleares , Plasmaferese , Centrais Elétricas , Lesões por Radiação/sangue , Lesões por Radiação/complicações , UcrâniaRESUMO
A patient with the graft-versus-host reaction is described. The description is illustrated with photographs of the patient, with histo- and electron grams.
Assuntos
Doença Enxerto-Hospedeiro/etiologia , Dermatopatias/etiologia , Adulto , Biópsia , Transplante de Medula Óssea/efeitos adversos , Terapia Combinada , Doença Enxerto-Hospedeiro/patologia , Doença Enxerto-Hospedeiro/prevenção & controle , Humanos , Masculino , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Recidiva , Pele/patologia , Dermatopatias/patologia , Dermatopatias/prevenção & controleRESUMO
Description is given of 11 patients with a severe form of protracted corticosteroid-dependent asthma. They died in status asthmaticus. Most of these patients had protracted status asthmaticus and cardiopulmonary failure. Pneumonia with toxic liver and kidney affection developed in some of them in parallel with glucocorticoid therapy. Long-term glucocorticoid treatment may give rise to vasculitis and thromboembolism of the pulmonary trunk. The principal disease can be aggravated by infection, administration of histoglobin, decrease in the dose of glucocorticosteroids or their discontinuation.
