RESUMO
Saga Pro is a food supplement product manufactured in Iceland and marketed internationally. It is claimed to have anti-nocturia effect and the flavonoid isoquercitrin has been suggested to play a role in this assumed activity. The purpose of this study was to identify and quantify the main flavonoids and furanocoumarins in the SagaPro tablets and to evaluate the importance of their presence. Isoquercitrin was identified as a constituent in an amount of 158 µg/tablet. This is a p.o. dosage highly unlikely to have an effect on nocturia or any other pharmacologically significant effect in humans. The main furanocoumarins, xanthotoxin and imperatorin, were also identified and quantified to 280 and 2 µg/tablet, respectively.
Assuntos
Angelica archangelica/química , Suplementos Nutricionais/análise , Noctúria/tratamento farmacológico , Flavonoides/análise , Furocumarinas/análise , Humanos , Metoxaleno/análise , Extratos Vegetais/análise , Folhas de Planta/química , Quercetina/análogos & derivados , Quercetina/análise , ComprimidosRESUMO
The anomalous acidic properties of the coarse grades of anhydrous calcium hydrogen phosphate are commented and a tentative elucidation of this is proposed.
Assuntos
Fosfatos de Cálcio/química , Dessecação , Composição de Medicamentos , Excipientes , Concentração de Íons de Hidrogênio , Solubilidade , SuspensõesRESUMO
Tablets manufactured from fine powder (average particle size, D[4,3] = 50.1 microm) benazepril hydrochloride exhibited unacceptable processing and quality properties whereas microcrystalline material (D[4,3] = 4.5-7.7 microm) furnished a product with good processing and quality characteristics.
Assuntos
Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/química , Benzazepinas/administração & dosagem , Benzazepinas/química , Algoritmos , Celulose , Química Farmacêutica , Composição de Medicamentos , Tamanho da Partícula , ComprimidosRESUMO
Tablets containing 91% lactose monohydrate and 4% starch pregelatinized exhibited the best technical properties in comparison to tablets of similar composition with either povidone plus croscarmellose sodium or hydroxypropylcellulose low substituted as binders/disintegrants.
Assuntos
Lactose/química , Comprimidos , Celulose/análogos & derivados , Celulose/química , Química Farmacêutica , Excipientes , Excipientes Farmacêuticos/química , Povidona/química , AmidoRESUMO
Tablets containing an angiotensin-converting enzyme inhibitor and either calcium sulphate dihydrate or lactose monohydrate as main excipients (fillers) exhibited similar technical properties and stability.
Assuntos
Sulfato de Cálcio/química , Excipientes/química , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/química , Química Farmacêutica , Composição de Medicamentos , Estabilidade de Medicamentos , Lactose , ComprimidosRESUMO
The presence of citric acid in the film coating of ranitidine hydrochloride tablets decreased discoloration.
Assuntos
Ácido Cítrico/química , Ranitidina/química , Antiulcerosos/química , Estabilidade de Medicamentos , Concentração de Íons de Hidrogênio , Comprimidos/químicaRESUMO
The formation of two oxidative degradates of diclofenac in solution and the solid state was demonstrated.
Assuntos
Anti-Inflamatórios não Esteroides/farmacocinética , Diclofenaco/farmacocinética , Oxirredução , Solubilidade , Comprimidos/farmacocinéticaRESUMO
Matrix tablets manufactured from a practically insoluble drug using Methocel K4M, Methocel K100LV, and mixtures thereof exhibited non-Fickian dissolution properties governed by both diffusion and erosion (value of diffusional exponent in Peppas's transport equation 0.7). The effects of these two hydroxypropyl methylcellulose (HPMC) varieties were nonlinear and antagonistic.
Assuntos
Metilcelulose/análogos & derivados , Difusão , Derivados da Hipromelose , Metilcelulose/administração & dosagem , Metilcelulose/química , SolubilidadeRESUMO
Tablets manufactured from micronized anhydrous nitrofurantoin exhibited unsatisfactory dissolution properties, whereas excellent results were obtained with unmilled drug material having fine particle size.
Assuntos
Nitrofurantoína/química , Tamanho da Partícula , Solubilidade , ComprimidosRESUMO
A chemical interaction between lisinopril and lactose was demonstrated and quantified in dilute mixtures in the solid state.
