Consumption of Gongronema latifolium Aqueous Leaf Extract During Lactation May Improve Metabolic Homeostasis in Young Adult Offspring.

BACKGROUND AND OBJECTIVE: Medicinal plants constitute a fundamental component of the traditional healthcare system in rural communities throughout Africa and Gongronema latifolium (GL), is widely trusted in Nigeria to have strong nutritional and medicinal values. This study was done to determine the effect of maternal consumption of GL during lactation in young adult offspring. MATERIALS AND METHODS: Twenty four female albino Wistar rats were used for this study and were randomly assigned to four (4) groups. Group I: Control, Group II, 100 mg kg-1, III, 200 mg kg-1 and IV: 400 mg kg-1 at delivery. The extract was administered orally and daily throughout lactation. RESULTS: At postnatal day 42, offspring of extract-treated groups showed a dose-related significant decrease (p<0.05) in body weight, food intake, glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and a significant increase in liver weight index, pancreatic weight index, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations of the offspring when compared with control in both sexes. Histological examination showed that GL extract caused histological alterations of the liver structures with various changes in the size of the sinusoids, with mild inflammatory cells without hepatotoxicity and cellular multiplication when compared with control. CONCLUSION: This study suggested that consumption of GL extract by lactating dams may improve metabolic homeostasis in young adult offspring.

Assessment of body mass index and blood pressure among university students in, Enugu, South East, Nigeria.

BACKGROUND: Body Mass Index (BMI) has been described as a significant predictor of Blood Pressure (B.P) but few studies have demonstrated this association in our environment. The study aims to determine the pattern of relationship between BMI and blood pressure in our environment. METHODOLOGY: Two thousand and ninety six (2096) students in two Universities located in Enugu, South East Nigeria completed the study. The blood pressure, weight and height were measured. Body mass index was calculated as weight in Kilograms divided by height in meters square (kg/m2). RESULTS: More females than males were underweight (9.4% versus 4.7%). More males than females were overweight (8% versus 4%).Obesity occurred more in males than females (7% versus 0.9%). Blood pressure parameters increased significantly with BMI (p < 0.0001) with higher values in males than in females; (the mean systolic blood pressure 124.88 +/- 10.97 mmHg versus 114.93 +/- 6.82 mmHg, P < 0.0001; the mean diastolic blood pressure was 80.1 +/- 7.2 mmHg versus 73.36 +/- 6.82 mmHg, p = 0.035 and the mean arterial Pressure (MAP) 95.02 +/- 7.78 mmHg versus 87.2 +/- 9.58 mmHg, p < 0.0001). CONCLUSION: A significant relationship between BMI and Blood pressure was demonstrated among university students in South East Nigeria.

Assessment of Body Mass Index and Blood Pressure among University Students in; Enugu; South East; Nigeria

Body Mass Index (BMI) has been described as a significant predictor of Blood Pressure (B.P) but few studies have demonstrated this association in our environment. The study aims to determine the pattern of relationship between BMI and blood pressure in our environment Two thousand and ninety six (2096) students in two Universities located in Enugu; South East Nigeria completed the study. The blood pressure; weight and height were measured. Body mass index was calculated as weight in Kilograms divided by height in meters square (kg/m ). More females than males were underweight (9.4versus 4.7). More males than females were overweight (8versus 4).Obesity occurred more in males than females (7versus 0.9).Blood pressure parameters increased significantly with BMI (p