[Shifts in subcellular content of blood serum and urine at asthma: animal model, clinic and monitoring data].

We reproduced mouse model of bronchial asthma, evaluated metabolic shifts of serum homeostasis during disease development, and compared these results with the data on metabolic shifts in bronchial asthma patients. In experimental mice pronounced pathological changes in the lungs, considerable lymphocytosis and decrease in neutrophil count were detected. Metabolic shifts were studied using method of laser correlation spectroscopy (LCS) of blood serum and urine. Method of LCS allows determining the dispersion composition of the studied fluid by the relative contribution of particle components into light scattering. The relative content of particles of different size.characterizes the direction of metabolic shifts in the organism. Similar patterns of particle distribution in biological fluids of experimental animals and patients suggest that LCS can be used as an additional method for evaluation of the severity of the disease and efficiency of therapy.

[Age-related characteristics of lipid changes in the lungs, heart and brain of albino rats in relation to dietary factors]. / Vozrastnye osobennosti izmeneniia lipidov legkikh, serdtsa i mozga belykh krys pod vliianiem dieticheskikh faktorov.

It has been studied how long-term periodical calorie-insufficient and growth-restraining nutrition of the Wistar albino rats influences the lipid metabolism. It is shown that diet has a marked effect on the levels of phospholipids, cholesterol, neutral lipids, fatty acids in different tissues. The lipid composition in aged rats with prolonged life is closer to that of young animals of the control group.