RESUMO
A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response of MCD published, VIH negative, induced with anti CD20.
Assuntos
Anticorpos Monoclonais/uso terapêutico , Hiperplasia do Linfonodo Gigante/tratamento farmacológico , Idoso , Anticorpos Monoclonais Murinos , Antígenos CD20 , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Hiperplasia do Linfonodo Gigante/complicações , Hiperplasia do Linfonodo Gigante/imunologia , Feminino , Soronegatividade para HIV , Infecções por Herpesviridae/complicações , Herpesvirus Humano 8 , Humanos , Pancitopenia/complicações , Indução de Remissão , RituximabRESUMO
A patient with advanced multiple myeloma (MM) and renal failure presented a severe chronic anemia requiring frequent blood transfusions. Treatment with recombinant human erythropoietin (rHuEPO) led to a rapid improvement of anemia, and further blood transfusions were not required. Pathophysiological studies about the erythropoiesis in patients with MM and trials with rHuEPO in myeloma-associated anemia are commented.