RESUMO
The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crush injury groups were treated prior to injury with an intravascular injection of either ANX1 (50 or 100 µg kg-1) or vehicle. EF was assessed by CN electrical stimulation at 2 and 7 days after CN injury with histomorphometric and immunohistochemical analysis. ANX1 demonstrated functional preservation as the increase in intracavernous pressure (ICP). A dose-response relationship regarding the effect on penile tissue was confirmed, and preservation of the penile dorsal nerves and anti-apoptotic effects in the corpus cavernosum (real P-value vs injured control). ANX1 treatment prevented collagen deposition and smooth muscle loss in the penis. ANX1 normalized the expression of vascular endothelial growth factor and decreased tumor necrosis factor-α in the lumen of the blood vessels of the organ. ANX1 proved effective in preserving EF in a rat model of neurogenic erectile dysfunction. ANX1 treatment before CN injury in rats improved erectile recovery, enhanced vascular regeneration and preserved the micro-architecture of the corpus cavernosum. The clinical availability of this compound merits application in penile rehabilitation studies following radical prostatectomy.
Assuntos
Anexina A1/farmacologia , Anti-Inflamatórios/farmacologia , Disfunção Erétil/tratamento farmacológico , Ereção Peniana/efeitos dos fármacos , Pênis/efeitos dos fármacos , Traumatismos dos Nervos Periféricos/complicações , Animais , Anexina A1/uso terapêutico , Modelos Animais de Doenças , Disfunção Erétil/etiologia , Disfunção Erétil/metabolismo , Disfunção Erétil/fisiopatologia , Masculino , Compressão Nervosa , Ereção Peniana/fisiologia , Pênis/metabolismo , Pênis/fisiopatologia , Traumatismos dos Nervos Periféricos/metabolismo , Traumatismos dos Nervos Periféricos/fisiopatologia , Ratos , Ratos Wistar , Fator de Necrose Tumoral alfa/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismoRESUMO
In this paper we try to examine the hypothesis that there exists differences due to the variable civil status (marriage versus single) in the 16 PF (Form A) between two spanish samples. The first sample consists of 60 general neurotic subjects and the second sample consists of 60 control subjects. The thesis is confirmed, finding in the first sample (general neurotic subjects) significative statistical differences between marriage and single subjects in the I, Q1, Q1V, Pnc (Blanc answers) and Random scale (Az) personality factors. In the control sample the differences are found in the following personality factors: B, C, F, H, O, Q2, Q3, Q1, Q11, Q1V, DM scale (Motivational distorsion) and Random scale (Az).
Assuntos
Casamento , Transtornos Neuróticos/psicologia , Inventário de Personalidade , Personalidade , Pessoa Solteira , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In this paper we try to examine the hypothesis that there exists differences due to the variable civil status (marriage versus single) in the 16 PF (Form A) between two spanish samples. The first sample consists of 60 general neurotic subjects and the second sample consists of 60 control subjects. The thesis is confirmed, finding in the first sample (general neurotic subjects) significative statistical differences between marriage and single subjects in the I, Q1, Q1V, Pnc (Blanc answers) and Random scale (Az) personality factors. In the control sample the differences are found in the following personality factors: B, C, F, H, O, Q2, Q3, Q1, Q11, Q1V, DM scale (Motivational distorsion) and Random scale (Az).