RESUMO
This study investigated the association between HLA antigens and inflammatory bowel disease in 65 Iraqi patients (50 ulcerative colitis, 15 Crohn disease) compared with 67 matched controls. At HLA class I region, the patients showed significantly increased frequencies of A9 and B41 and a decrease of A11. Similar results were found when the clinical types were considered separately, except for A11, which was not significant. At HLA class II region, DR8 was significantly increased in the total patients, but the association was not maintained for ulcerative colitis or Crohn disease patients; instead Crohn disease was positively associated with DQ1. Comparing the clinical types revealed a significant difference in the antigen 816, suggesting that 816 is a differentiating marker in the disease.
Assuntos
Colite Ulcerativa/sangue , Colite Ulcerativa/genética , Doença de Crohn/sangue , Doença de Crohn/genética , Antígenos HLA , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Colite Ulcerativa/epidemiologia , Colite Ulcerativa/imunologia , Doença de Crohn/epidemiologia , Doença de Crohn/imunologia , Feminino , Marcadores Genéticos/genética , Marcadores Genéticos/imunologia , Predisposição Genética para Doença/epidemiologia , Predisposição Genética para Doença/etiologia , Predisposição Genética para Doença/genética , Variação Genética/genética , Variação Genética/imunologia , Antígenos HLA/sangue , Antígenos HLA/genética , Antígenos HLA/imunologia , Antígenos HLA-A/sangue , Antígeno HLA-A11 , Antígenos HLA-B/sangue , Antígenos HLA-DQ/sangue , Antígenos HLA-DR/sangue , Subtipos Sorológicos de HLA-DR , Humanos , Iraque/epidemiologia , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético/genética , Polimorfismo Genético/imunologia , Adulto JovemRESUMO
This study investigated the association between HLA antigens and inflammatory bowel disease in 65 Iraqi patients [50 ulcerative colitis, 15 Crohn disease] compared with 67 matched controls. At HLA class I region, the patients showed significantly increased frequencies of A9 and B41 and a decrease of A11. Similar results were found when the clinical types were considered separately, except for A11, which was not significant. At HLA class II region, DR8 was significantly increased in the total patients, but the association was not maintained for ulcerative colitis or Crohn disease patients; instead Crohn disease was positively associated with DQ1. Comparing the clinical types revealed a significant difference in the antigen B16, suggesting that B16 is a differentiating marker in the disease
