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1.
Nephron ; 23(4): 205-9, 1979.
Artigo em Inglês | MEDLINE | ID: mdl-471144

RESUMO

Renal tubular necrosis was observed following intramuscular injections of cephalothin into rats. Lesions were consistently produced with 5.0g/kg and were maximal in severity at the 2nd and 3rd days following injection. Renal tubular necrosis following cephalothin was similar in morphology to that produced by nephrotoxic doses (2.0 g/kg) of cephaloridine. The nephrotoxic potential of cephalothin has been demonstrated in the rat model and caution is urged in using large doses of cephalothin.


Assuntos
Injúria Renal Aguda/induzido quimicamente , Cefalotina/efeitos adversos , Necrose Tubular Aguda/induzido quimicamente , Rim/patologia , Animais , Cefalotina/administração & dosagem , Relação Dose-Resposta a Droga , Injeções Intramusculares , Necrose Tubular Aguda/patologia , Masculino , Ratos
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