Particle Dynamics at the Onset of the Granular Gas-Liquid Transition.

We study experimentally the dynamical behavior of few large tracer particles placed in a quasi-2D granular "gas" made of many small beads in a low-gravity environment. Multiple inelastic collisions transfer momentum from the uniaxially driven gas to the tracers whose velocity distributions are studied through particle tracking. Analyzing these distributions for an increasing system density reveals that translational energy equipartition is reached at the onset of the gas-liquid granular transition corresponding to the emergence of local clusters. The dynamics of a few tracer particles thus appears as a simple and accurate tool to detect this transition. A model is proposed for describing accurately the formation of local heterogeneities.

Interaction between three stress-related gene polymorphisms and food addiction increases the risk to develop obesity in a sample of Mexican people attending a nutrition clinic.

Chronic stress exposure impacts negatively in individuals leading to food addiction, overweight or obesity. Stress-genes and their translation products are responsible for the responses of humans to adverse environments. Alterations in stress-genes expression or protein function may induce behaviors as compulsive eating of high-energy containing food, which decreases stress-induced negative feelings. However, chronic stress is not assessed in Mexican population. We analyzed here the association between polymorphisms of CRH, CRHR2 and glucocorticoids (GR, NR3C1) receptor genes with food addiction and obesity and overweight in Mexican patients of a Nutrition Clinic. We recruited 508 individuals of both genders, who accepted to participate in the study at their first visit to the clinic, obtaining their fat mass percentage and a blood sample for the genetic analysis. Participants answered the Yale's food addiction scale and were subjected to a Trier social test, as an acute stressful stimulus. Pre and post-test saliva samples were obtained to evaluate cortisol levels and adrenal axis' response to the acute stress. The 63% of participants classified as stressed (S); 6.5% of normal-weight individuals showed food-addiction, whereas 63% of participants with food-addiction were also stressed. The fat mass percentage was greater in stress-addiction than in stressed non-addiction participants. The best interaction model for obesity development risk comprehended the presence of polymorphisms of the three genes that in combination with food addiction increased the risk for developing obesity 2.8-4-fold. Thus, frequent stress exposure favors food-addiction, which along with genetic susceptibility seems to add up to Mexican obesity/overweight rates.

Saturation of the Inverse Cascade in Surface Gravity-Wave Turbulence.

We report on the observation of surface gravity-wave turbulence at scales larger than the forcing ones in a large basin. In addition to the downscale transfer usually reported in gravity-wave turbulence, an upscale transfer is observed, interpreted as the inverse cascade of weak turbulence theory. A steady state is achieved when the inverse cascade reaches a scale in between the forcing wavelength and the basin size, but far from the latter. This inverse cascade saturation, which depends on the wave steepness, is probably due to the emergence of nonlinear dissipative structures such as sharp-crested waves.

Wave Turbulence on the Surface of a Fluid in a High-Gravity Environment.

We report on the observation of gravity-capillary wave turbulence on the surface of a fluid in a high-gravity environment. By using a large-diameter centrifuge, the effective gravity acceleration is tuned up to 20 times Earth's gravity. The transition frequency between the gravity and capillary regimes is thus increased up to one decade as predicted theoretically. A frequency power-law wave spectrum is observed in each regime and is found to be independent of the gravity level and of the wave steepness. While the timescale separation required by weak turbulence is well verified experimentally regardless of the gravity level, the nonlinear and dissipation timescales are found to be independent of the scale, as a result of the finite size effects of the system (large-scale container modes) that are not taken currently into account theoretically.

An instrument for studying granular media in low-gravity environment.

A new experimental facility has been designed and constructed to study driven granular media in a low-gravity environment. This versatile instrument, fully automatized, with a modular design based on several interchangeable experimental cells, allows us to investigate research topics ranging from dilute to dense regimes of granular media such as granular gas, segregation, convection, sound propagation, jamming, and rheology-all without the disturbance by gravitational stresses active on Earth. Here, we present the main parameters, protocols, and performance characteristics of the instrument. The current scientific objectives are then briefly described and, as a proof of concept, some first selected results obtained in low gravity during parabolic flight campaigns are presented.

Pressure dependence of the electrical transport in granular materials.

We report on systematic measurements of the electrical resistance of one- and three-dimensional (1D and 3D) metallic and oxidized granular materials under uni-axial compression. Whatever the dimension of the packing, the resistance follows a power law versus the pressure ([Formula: see text]), with an exponent [Formula: see text] much larger than the ones expected either with elastic or plastic contact between the grains. A simple model based on a statistical description of the micro-contacts between two grains is proposed. It shows that the strong dependence of the resistance on the pressure applied to the granular media is a consequence of large variabilities and heterogeneities present at the contact surface between two grains. Then, the effect of the three-dimensional structure of the packing is investigated using a renormalization process. This allows to reconcile two extreme approaches of a 3D lattice of widely distributed resistances: the effective medium and the percolation theories.

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Mice with a mutation in the Clock gene (ClockΔ19) have been identified as a model of mania; however, the mechanisms that underlie this phenotype, and the changes in the brain that are necessary for lithium's effectiveness on these mice remain unclear. Here, we find that cholecystokinin (Cck) is a direct transcriptional target of CLOCK and levels of Cck are reduced in the ventral tegmental area (VTA) of ClockΔ19 mice. Selective knockdown of Cck expression via RNA interference in the VTA of wild-type mice produces a manic-like phenotype. Moreover, chronic treatment with lithium restores Cck expression to near wild-type and this increase is necessary for the therapeutic actions of lithium. The decrease in Cck expression in the ClockΔ19 mice appears to be due to a lack of interaction with the histone methyltransferase, MLL1, resulting in decreased histone H3K4me3 and gene transcription, an effect reversed by lithium. Human postmortem tissue from bipolar subjects reveals a similar increase in Cck expression in the VTA with mood stabilizer treatment. These studies identify a key role for Cck in the development and treatment of mania, and describe some of the molecular mechanisms by which lithium may act as an effective antimanic agent.

Gravity wave turbulence revealed by horizontal vibrations of the container.

We experimentally study the role of forcing on gravity-capillary wave turbulence. Previous laboratory experiments using spatially localized forcing (vibrating blades) have shown that the frequency power-law exponent of the gravity wave spectrum depends on the forcing parameters. By horizontally vibrating the whole container, we observe a spectrum exponent that does not depend on the forcing parameters for both gravity and capillary regimes. This spatially extended forcing leads to a gravity spectrum exponent in better agreement with the theory than by using a spatially localized forcing. The role of the vessel shape has been also studied. Finally, the wave spectrum is found to scale linearly with the injected power for both regimes whatever the forcing type used.

Carpe diem, Carpe ampulla: a numerical model as an aid to the design of child-resistant closures.

The population of most developed countries is ageing. Despite continuing medical advances, ageing brings with it a host of issues, not least a loss in strength and dexterity. One major area of concern is the ability of elderly consumers to access packaged goods such as food and medicines. In previous studies, the authors developed a numerical model of a human hand that was used to investigate the effect of physical dimensions and choice of grip on joint stresses to aid the understanding between physical effort, ability and discomfort. This previous work was supported by ethnographic studies and led to recommendations for packaging design. In this paper, a small ethnographic study is undertaken which identifies the grip types used to access to a product that is known to cause particular difficulties for the elderly, the "squeeze and turn" child-resistant closure or CRC, commonly used on medicines and cleaning products. One of the grip types used was chosen to be modelled using the numerical model developed in previous studies by the author. Model geometry and loading were adapted to simulate the "squeeze and turn" nature of the initial opening for closures of this type. A series of studies were then undertaken using different hand geometries; an average male hand, an average female hand and a fifth percentile female hand. The prediction from the model here is that female users with smaller hands will experience more discomfort when accessing squeeze and turn CRC's and that the turn process whilst maintaining the squeeze is problematic.

Observation of axisymmetric solitary waves on the surface of a ferrofluid.

We report the first observation of axisymmetric solitary waves on the surface of a cylindrical magnetic fluid layer surrounding a current-carrying metallic tube. According to the ratio between the magnetic and capillary forces, both elevation and depression solitary waves are observed with profiles in good agreement with theoretical predictions based on the magnetic analogue of the Korteweg-de Vries equation. We also report the first measurements of the velocity and the dispersion relation of axisymmetric linear waves propagating on the cylindrical ferrofluid layer that are found in good agreement with theoretical predictions.

Some aspects of electrical conduction in granular systems of various dimensions.

We report on measurements of the electrical conductivity in both a 2D triangular lattice of metallic beads and in a chain of beads. The voltage/current characteristics are qualitatively similar in both experiments. At low applied current, the voltage is found to increase logarithmically in good agreement with a model of widely distributed resistances in series. At high enough current, the voltage saturates due to the local welding of microcontacts between beads. The frequency dependence of the saturation voltage gives an estimate of the size of these welded microcontacts. The DC value of the saturation voltage ( approximately 0.4 V per contact) gives an indirect measure of the number of welded contact carrying the current within the 2D lattice. Also, a new measurement technique provides a map of the current paths within the 2D lattice of beads. For an isotropic compression of the 2D granular medium, the current paths are localized in few discrete linear paths. This quasi-one-dimensional nature of the electrical conductivity thus explains the similarity between the characteristics in the 1D and 2D systems.

Observation of intermittency in wave turbulence.

We report the observation of intermittency in gravity-capillary wave turbulence on the surface of mercury. We measure the temporal fluctuations of surface wave amplitude at a given location. We show that the shape of the probability density function of the local slope increments of the surface waves strongly changes across the time scales. The related structure functions and the flatness are found to be power laws of the time scale on more than one decade. The exponents of these power laws increase nonlinearly with the order of the structure function. All these observations show the intermittent nature of the increments of the local slope in wave turbulence. We discuss the possible origin of this intermittency.

Curación de un síndrome PFAPA / Curing of the PFAPA syndrome

Se presenta el caso de una niña de 23 meses que presentaba episodios febriles con una periodicidad de 22+/-4 días. Se realiza diagnóstico diferencial entre las causas de fiebre periódica. Con el diagnóstico de síndrome PFAPA (fiebre periódica, aftas, faringitis y adenitis cervical), se trata con adenoide-amigdalectomía, obteniéndose un resultado excelente (AU)

Heap corrugation and hexagon formation of powder under vertical vibrations.

We report free-surface instabilities in a deep bed of fine granular material of irregular shape under vertical vibrations. At low frequency of vibration, the conical heap due to convective flow becomes unstable above a critical amplitude of vibration and acquires an azimuthal dependence which makes the heap surface corrugated. At even higher amplitude, the heap is no longer stable and splits into small heaps on a hexagonal lattice. At high frequency, we observe standing waves (stripes) at the same frequency as the driving one. The main mechanism of these instabilities can be traced back to the presence of the surrounding gas, since they vanish under vacuum conditions.

Linfangioma quístico retroperitoneal: presentación de un caso y revisión de la literatura / Retroperitoneal cystic lymphangioma: presentation of a case and review of literature

Se presenta un paciente con un linfangioma quístico retroperitoneal, entidad muy poco frecuente. Se exponen el estudio clínico y los exámenes complementarios realizados, los que incluyeron urograma descendente, nefrotomograma, arteriografía, estómago y duodeno, colon por enema y laparoscopia. Se describe la técnica quirúrgica empleada y el resultado anatomopatológico de la pieza extraída. Se realiza una revisión de la bibliografía internacional y se exponen los criterios más importantes (AU)

Manipulaciones ginecobstétricas como causa de estenosis uretral / Gynecobstrical manipulations as a cause of urethral stenosis

Se realiza una breve reseña anatómica de la región uretrovaginal. Se describen el mecanismo etiopatogénico de la formación de estenosis uretral del tipo periuretritis fibrosa a punto de partida de partos múltiples, aplicación de fórceps y colporrafías anteriores. Se presentan datos estadísticos sobre 62 casos portadores de esta patología, así como 4 casos demostrativos de la entidad cuya etiopatogenia deriva de manipulaciones ginecobstétricas (AU)