EEG Amplitude Modulation Analysis across Mental Tasks: Towards Improved Active BCIs.

Brain-computer interface (BCI) technology has emerged as an influential communication tool with extensive applications across numerous fields, including entertainment, marketing, mental state monitoring, and particularly medical neurorehabilitation. Despite its immense potential, the reliability of BCI systems is challenged by the intricacies of data collection, environmental factors, and noisy interferences, making the interpretation of high-dimensional electroencephalogram (EEG) data a pressing issue. While the current trends in research have leant towards improving classification using deep learning-based models, our study proposes the use of new features based on EEG amplitude modulation (AM) dynamics. Experiments on an active BCI dataset comprised seven mental tasks to show the importance of the proposed features, as well as their complementarity to conventional power spectral features. Through combining the seven mental tasks, 21 binary classification tests were explored. In 17 of these 21 tests, the addition of the proposed features significantly improved classifier performance relative to using power spectral density (PSD) features only. Specifically, the average kappa score for these classifications increased from 0.57 to 0.62 using the combined feature set. An examination of the top-selected features showed the predominance of the AM-based measures, comprising over 77% of the top-ranked features. We conclude this paper with an in-depth analysis of these top-ranked features and discuss their potential for use in neurophysiology.

Neuromorphic Computing via Fission-based Broadband Frequency Generation.

The performance limitations of traditional computer architectures have led to the rise of brain-inspired hardware, with optical solutions gaining popularity due to the energy efficiency, high speed, and scalability of linear operations. However, the use of optics to emulate the synaptic activity of neurons has remained a challenge since the integration of nonlinear nodes is power-hungry and, thus, hard to scale. Neuromorphic wave computing offers a new paradigm for energy-efficient information processing, building upon transient and passively nonlinear interactions between optical modes in a waveguide. Here, an implementation of this concept is presented using broadband frequency conversion by coherent higher-order soliton fission in a single-mode fiber. It is shown that phase encoding on femtosecond pulses at the input, alongside frequency selection and weighting at the system output, makes transient spectro-temporal system states interpretable and allows for the energy-efficient emulation of various digital neural networks. The experiments in a compact, fully fiber-integrated setup substantiate an anticipated enhancement in computational performance with increasing system nonlinearity. The findings suggest that broadband frequency generation, accessible on-chip and in-fiber with off-the-shelf components, may challenge the traditional approach to node-based brain-inspired hardware design, ultimately leading to energy-efficient, scalable, and dependable computing with minimal optical hardware requirements.

Automated Multi-Wavelength Quality Assessment of Photoplethysmography Signals Using Modulation Spectrum Shape Features.

Photoplethysmography (PPG) is used to measure blood volume changes in the microvascular bed of tissue. Information about these changes along time can be used for estimation of various physiological parameters, such as heart rate variability, arterial stiffness, and blood pressure, to name a few. As a result, PPG has become a popular biological modality and is widely used in wearable health devices. However, accurate measurement of various physiological parameters requires good-quality PPG signals. Therefore, various signal quality indexes (SQIs) for PPG signals have been proposed. These metrics have usually been based on statistical, frequency, and/or template analyses. The modulation spectrogram representation, however, captures the second-order periodicities of a signal and has been shown to provide useful quality cues for electrocardiograms and speech signals. In this work, we propose a new PPG quality metric based on properties of the modulation spectrum. The proposed metric is tested using data collected from subjects while they performed various activity tasks contaminating the PPG signals. Experiments on this multi-wavelength PPG dataset show the combination of proposed and benchmark measures significantly outperforming several benchmark SQIs with improvements of 21.3% BACC (balanced accuracy) for green, 21.6% BACC for red, and 19.0% BACC for infrared wavelengths, respectively, for PPG quality detection tasks. The proposed metrics also generalize for cross-wavelength PPG quality detection tasks.

Using CNN Saliency Maps and EEG Modulation Spectra for Improved and More Interpretable Machine Learning-Based Alzheimer's Disease Diagnosis.

Biomarkers based on resting-state electroencephalography (EEG) signals have emerged as a promising tool in the study of Alzheimer's disease (AD). Recently, a state-of-the-art biomarker was found based on visual inspection of power modulation spectrograms where three "patches" or regions from the modulation spectrogram were proposed and used for AD diagnostics. Here, we propose the use of deep neural networks, in particular convolutional neural networks (CNNs) combined with saliency maps, trained on power modulation spectrogram inputs to find optimal patches in a data-driven manner. Experiments are conducted on EEG data collected from fifty-four participants, including 20 healthy controls, 19 patients with mild AD, and 15 moderate-to-severe AD patients. Five classification tasks are explored, including the three-class problem, early-stage detection (control vs. mild-AD), and severity level detection (mild vs. moderate-to-severe). Experimental results show the proposed biomarkers outperform the state-of-the-art benchmark across all five tasks, as well as finding complementary modulation spectrogram regions not previously seen via visual inspection. Lastly, experiments are conducted on the proposed biomarkers to test their sensitivity to age, as this is a known confound in AD characterization. Across all five tasks, none of the proposed biomarkers showed a significant relationship with age, thus further highlighting their usefulness for automated AD diagnostics.

Quantifying time perception during virtual reality gameplay using a multimodal biosensor-instrumented headset: a feasibility study.

We have all experienced the sense of time slowing down when we are bored or speeding up when we are focused, engaged, or excited about a task. In virtual reality (VR), perception of time can be a key aspect related to flow, immersion, engagement, and ultimately, to overall quality of experience. While several studies have explored changes in time perception using questionnaires, limited studies have attempted to characterize them objectively. In this paper, we propose the use of a multimodal biosensor-embedded VR headset capable of measuring electroencephalography (EEG), electrooculography (EOG), electrocardiography (ECG), and head movement data while the user is immersed in a virtual environment. Eight gamers were recruited to play a commercial action game comprised of puzzle-solving tasks and first-person shooting and combat. After gameplay, ratings were given across multiple dimensions, including (1) the perception of time flowing differently than usual and (2) the gamers losing sense of time. Several features were extracted from the biosignals, ranked based on a two-step feature selection procedure, and then mapped to a predicted time perception rating using a Gaussian process regressor. Top features were found to come from the four signal modalities and the two regressors, one for each time perception scale, were shown to achieve results significantly better than chance. An in-depth analysis of the top features is presented with the hope that the insights can be used to inform the design of more engaging and immersive VR experiences.

Enhancing motor imagery detection efficacy using multisensory virtual reality priming.

Brain-computer interfaces (BCI) have been developed to allow users to communicate with the external world by translating brain activity into control signals. Motor imagery (MI) has been a popular paradigm in BCI control where the user imagines movements of e.g., their left and right limbs and classifiers are then trained to detect such intent directly from electroencephalography (EEG) signals. For some users, however, it is difficult to elicit patterns in the EEG signal that can be detected with existing features and classifiers. As such, new user control strategies and training paradigms have been highly sought-after to help improve motor imagery performance. Virtual reality (VR) has emerged as one potential tool where improvements in user engagement and level of immersion have shown to improve BCI accuracy. Motor priming in VR, in turn, has shown to further enhance BCI accuracy. In this pilot study, we take the first steps to explore if multisensory VR motor priming, where haptic and olfactory stimuli are present, can improve motor imagery detection efficacy in terms of both improved accuracy and faster detection. Experiments with 10 participants equipped with a biosensor-embedded VR headset, an off-the-shelf scent diffusion device, and a haptic glove with force feedback showed that significant improvements in motor imagery detection could be achieved. Increased activity in the six common spatial pattern filters used were also observed and peak accuracy could be achieved with analysis windows that were 2 s shorter. Combined, the results suggest that multisensory motor priming prior to motor imagery could improve detection efficacy.

Estimating distribution shifts for predicting cross-subject generalization in electroencephalography-based mental workload assessment.

Assessment of mental workload in real-world conditions is key to ensuring the performance of workers executing tasks that demand sustained attention. Previous literature has employed electroencephalography (EEG) to this end despite having observed that EEG correlates of mental workload vary across subjects and physical strain, thus making it difficult to devise models capable of simultaneously presenting reliable performance across users. Domain adaptation consists of a set of strategies that aim at allowing for improving machine learning systems performance on unseen data at training time. Such methods, however, might rely on assumptions over the considered data distributions, which typically do not hold for applications of EEG data. Motivated by this observation, in this work we propose a strategy to estimate two types of discrepancies between multiple data distributions, namely marginal and conditional shifts, observed on data collected from different subjects. Besides shedding light on the assumptions that hold for a particular dataset, the estimates of statistical shifts obtained with the proposed approach can be used for investigating other aspects of a machine learning pipeline, such as quantitatively assessing the effectiveness of domain adaptation strategies. In particular, we consider EEG data collected from individuals performing mental tasks while running on a treadmill and pedaling on a stationary bike and explore the effects of different normalization strategies commonly used to mitigate cross-subject variability. We show the effects that different normalization schemes have on statistical shifts and their relationship with the accuracy of mental workload prediction as assessed on unseen participants at training time.

Multimodal resting-state connectivity predicts affective neurofeedback performance.

Neurofeedback has been suggested as a potential complementary therapy to different psychiatric disorders. Of interest for this approach is the prediction of individual performance and outcomes. In this study, we applied functional connectivity-based modeling using electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) modalities to (i) investigate whether resting-state connectivity predicts performance during an affective neurofeedback task and (ii) evaluate the extent to which predictive connectivity profiles are correlated across EEG and fNIRS techniques. The fNIRS oxyhemoglobin and deoxyhemoglobin concentrations and the EEG beta and gamma bands modulated by the alpha frequency band (beta-m-alpha and gamma-m-alpha, respectively) recorded over the frontal cortex of healthy subjects were used to estimate functional connectivity from each neuroimaging modality. For each connectivity matrix, relevant edges were selected in a leave-one-subject-out procedure, summed into "connectivity summary scores" (CSS), and submitted as inputs to a support vector regressor (SVR). Then, the performance of the left-out-subject was predicted using the trained SVR model. Linear relationships between the CSS across both modalities were evaluated using Pearson's correlation. The predictive model showed a mean absolute error smaller than 20%, and the fNIRS oxyhemoglobin CSS was significantly correlated with the EEG gamma-m-alpha CSS (r = -0.456, p = 0.030). These results support that pre-task electrophysiological and hemodynamic resting-state connectivity are potential predictors of neurofeedback performance and are meaningfully coupled. This investigation motivates the use of joint EEG-fNIRS connectivity as outcome predictors, as well as a tool for functional connectivity coupling investigation.

Cross-Language Speech Emotion Recognition Using Bag-of-Word Representations, Domain Adaptation, and Data Augmentation.

To date, several methods have been explored for the challenging task of cross-language speech emotion recognition, including the bag-of-words (BoW) methodology for feature processing, domain adaptation for feature distribution "normalization", and data augmentation to make machine learning algorithms more robust across testing conditions. Their combined use, however, has yet to be explored. In this paper, we aim to fill this gap and compare the benefits achieved by combining different domain adaptation strategies with the BoW method, as well as with data augmentation. Moreover, while domain adaptation strategies, such as the correlation alignment (CORAL) method, require knowledge of the test data language, we propose a variant that we term N-CORAL, in which test languages (in our case, Chinese) are mapped to a common distribution in an unsupervised manner. Experiments with German, French, and Hungarian language datasets were performed, and the proposed N-CORAL method, combined with BoW and data augmentation, was shown to achieve the best arousal and valence prediction accuracy, highlighting the usefulness of the proposed method for "in the wild" speech emotion recognition. In fact, N-CORAL combined with BoW was shown to provide robustness across languages, whereas data augmentation provided additional robustness against cross-corpus nuance factors.

Modulation Spectral Signal Representation for Quality Measurement and Enhancement of Wearable Device Data: A Technical Note.

Wearable devices are burgeoning, and applications across numerous verticals are emerging, including human performance monitoring, at-home patient monitoring, and health tracking, to name a few. Off-the-shelf wearables have been developed with focus on portability, usability, and low-cost. As such, when deployed in highly ecological settings, wearable data can be corrupted by artifacts and by missing data, thus severely hampering performance. In this technical note, we overview a signal processing representation called the modulation spectrum. The representation quantifies the rate-of-change of different spectral magnitude components and is shown to separate signal from noise, thus allowing for improved quality measurement, quality enhancement, and noise-robust feature extraction, as well as for disease characterization. We provide an overview of numerous applications developed by the authors over the last decade spanning different wearable modalities and list the results obtained from experimental results alongside comparisons with various state-of-the-art benchmark methods. Open-source software is showcased with the hope that new applications can be developed. We conclude with a discussion on possible future research directions, such as context awareness, signal compression, and improved input representations for deep learning algorithms.

Immersive media experience: a survey of existing methods and tools for human influential factors assessment.

Virtual reality (VR) applications, especially those where the user is untethered to a computer, are becoming more prevalent as new hardware is developed, computational power and artificial intelligence algorithms are available, and wireless communication networks are becoming more reliable, fast, and providing higher reliability. In fact, recent projections show that by 2022 the number of VR users will double, suggesting the sector was not negatively affected by the worldwide COVID-19 pandemic. The success of any immersive communication system is heavily dependent on the user experience it delivers, thus now more than ever has it become crucial to develop reliable models of immersive media experience (IMEx). In this paper, we survey the literature for existing methods and tools to assess human influential factors (HIFs) related to IMEx. In particular, subjective, behavioural, and psycho-physiological methods are covered. We describe tools available to monitor these HIFs, including the user's sense of presence and immersion, cybersickness, and mental/affective states, as well as their role in overall experience. Special focus is placed on psycho-physiological methods, as it was found that such in-depth evaluation was lacking from the existing literature. We conclude by touching on emerging applications involving multiple-sensorial immersive media and provide suggestions for future research directions to fill existing gaps. It is hoped that this survey will be useful for researchers interested in building new immersive (adaptive) applications that maximize user experience.

Predicting Driver Stress Levels with a Sensor-Equipped Steering Wheel and a Quality-Aware Heart Rate Measurement Algorithm.

Unobtrusive monitoring of driver mental states has been regarded as an important element in improving the safety of existing transportation systems. While many solutions exist relying on camera-based systems for e.g., drowsiness detection, these can be sensitive to varying lighting conditions and to driver facial accessories, such as eye/sunglasses. In this work, we evaluate the use of physiological signals derived from sensors embedded directly into the steering wheel. In particular, we are interested in monitoring driver stress levels. To achieve this goal, we first propose a modulation spectral signal representation to reliably extract electrocardiogram (ECG) signals from the steering wheel sensors, thus allowing for heart rate and heart rate variability features to be computed. When input to a simple logistic regression classifier, we show that up to 72% accuracy can be achieved when discriminating between stressful and non-stressful driving conditions. In particular, the proposed modulation spectral signal representation allows for direct quality assessment of the obtained heart rate information, thus can provide additional intelligence to autonomous driver monitoring systems.

Remote COPD Severity and Exacerbation Detection Using Heart Rate and Activity Data Measured from a Wearable Device.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of human mortality worldwide. Traditionally, estimating COPD severity has been done in controlled clinical conditions using cough sounds, respiration, and heart rate variability, with the latter reporting insights on the autonomic dysfunction caused by the disease. Advancements in remote monitoring and wearable device technologies, in turn, have allowed for remote COPD monitoring in daily life conditions. In this study, we explore the potential for predicting COPD severity and exacerbation using a low-cost wearable device that measures heart rate and activity data. We collected smartwatch sensor data from 35 COPD patients over a period of three months. Our evaluation shows that future trajectory of the disease can be predicted using only the first few days of continuous unobtrusive wearable data collected from COPD patients. Using features extracted from wearable device an Isolation Forest was able to predict exacerbation with an area under curve (AUC) 0.69 thus showing improvement over a random choice classifier.

Multimodal Prediction of Alzheimer's Disease Severity Level Based on Resting-State EEG and Structural MRI.

While several biomarkers have been developed for the detection of Alzheimer's disease (AD), not many are available for the prediction of disease severity, particularly for patients in the mild stages of AD. In this paper, we explore the multimodal prediction of Mini-Mental State Examination (MMSE) scores using resting-state electroencephalography (EEG) and structural magnetic resonance imaging (MRI) scans. Analyses were carried out on a dataset comprised of EEG and MRI data collected from 89 patients diagnosed with minimal-mild AD. Three feature selection algorithms were assessed alongside four machine learning algorithms. Results showed that while MRI features alone outperformed EEG features, when both modalities were combined, improved results were achieved. The top-selected EEG features conveyed information about amplitude modulation rate-of-change, whereas top-MRI features comprised information about cortical area and white matter volume. Overall, a root mean square error between predicted MMSE values and true MMSE scores of 1.682 was achieved with a multimodal system and a random forest regression model.

Neurofeedback and the Aging Brain: A Systematic Review of Training Protocols for Dementia and Mild Cognitive Impairment.

Dementia describes a set of symptoms that occur in neurodegenerative disorders and that is characterized by gradual loss of cognitive and behavioral functions. Recently, non-invasive neurofeedback training has been explored as a potential complementary treatment for patients suffering from dementia or mild cognitive impairment. Here we systematically reviewed studies that explored neurofeedback training protocols based on electroencephalography or functional magnetic resonance imaging for these groups of patients. From a total of 1,912 screened studies, 10 were included in our final sample (N = 208 independent participants in experimental and N = 81 in the control groups completing the primary endpoint). We compared the clinical efficacy across studies, and evaluated their experimental designs and reporting quality. In most studies, patients showed improved scores in different cognitive tests. However, data from randomized controlled trials remains scarce, and clinical evidence based on standardized metrics is still inconclusive. In light of recent meta-research developments in the neurofeedback field and beyond, quality and reporting practices of individual studies are reviewed. We conclude with recommendations on best practices for future studies that investigate the effects of neurofeedback training in dementia and cognitive impairment.

Adaptive Filtering for Improved EEG-Based Mental Workload Assessment of Ambulant Users.

Recently, due to the emergence of mobile electroencephalography (EEG) devices, assessment of mental workload in highly ecological settings has gained popularity. In such settings, however, motion and other common artifacts have been shown to severely hamper signal quality and to degrade mental workload assessment performance. Here, we show that classical EEG enhancement algorithms, conventionally developed to remove ocular and muscle artifacts, are not optimal in settings where participant movement (e.g., walking or running) is expected. As such, an adaptive filter is proposed that relies on an accelerometer-based referential signal. We show that when combined with classical algorithms, accurate mental workload assessment is achieved. To test the proposed algorithm, data from 48 participants was collected as they performed the Revised Multi-Attribute Task Battery-II (MATB-II) under a low and a high workload setting, either while walking/jogging on a treadmill, or using a stationary exercise bicycle. Accuracy as high as 95% could be achieved with a random forest based mental workload classifier with ambulant users. Moreover, an increase in gamma activity was found in the parietal cortex, suggesting a connection between sensorimotor integration, attention, and workload in ambulant users.

Affective Neurofeedback Under Naturalistic Conditions: A Mini-Review of Current Achievements and Open Challenges.

Affective neurofeedback training allows for the self-regulation of the putative circuits of emotion regulation. This approach has recently been studied as a possible additional treatment for psychiatric disorders, presenting positive effects in symptoms and behaviors. After neurofeedback training, a critical aspect is the transference of the learned self-regulation strategies to outside the laboratory and how to continue reinforcing these strategies in non-controlled environments. In this mini-review, we discuss the current achievements of affective neurofeedback under naturalistic setups. For this, we first provide a brief overview of the state-of-the-art for affective neurofeedback protocols. We then discuss virtual reality as a transitional step toward the final goal of "in-the-wild" protocols and current advances using mobile neurotechnology. Finally, we provide a discussion of open challenges for affective neurofeedback protocols in-the-wild, including topics such as convenience and reliability, environmental effects in attention and workload, among others.

WAUC: A Multi-Modal Database for Mental Workload Assessment Under Physical Activity.

Assessment of mental workload is crucial for applications that require sustained attention and where conditions such as mental fatigue and drowsiness must be avoided. Previous work that attempted to devise objective methods to model mental workload were mainly based on neurological or physiological data collected when the participants performed tasks that did not involve physical activity. While such models may be useful for scenarios that involve static operators, they may not apply in real-world situations where operators are performing tasks under varying levels of physical activity, such as those faced by first responders, firefighters, and police officers. Here, we describe WAUC, a multimodal database of mental Workload Assessment Under physical aCtivity. The study involved 48 participants who performed the NASA Revised Multi-Attribute Task Battery II under three different activity level conditions. Physical activity was manipulated by changing the speed of a stationary bike or a treadmill. During data collection, six neural and physiological modalities were recorded, namely: electroencephalography, electrocardiography, breathing rate, skin temperature, galvanic skin response, and blood volume pulse, in addition to 3-axis accelerometry. Moreover, participants were asked to answer the NASA Task Load Index questionnaire after each experimental section, as well as rate their physical fatigue level on the Borg fatigue scale. In order to bring our experimental setup closer to real-world situations, all signals were monitored using wearable, off-the-shelf devices. In this paper, we describe the adopted experimental protocol, as well as validate the subjective, neural, and physiological data collected. The WAUC database, including the raw data and features, subjective ratings, and scripts to reproduce the experiments reported herein will be made available at: http://musaelab.ca/resources/.

PASS: A Multimodal Database of Physical Activity and Stress for Mobile Passive Body/ Brain-Computer Interface Research.

With the burgeoning of wearable devices and passive body/brain-computer interfaces (B/BCIs), automated stress monitoring in everyday settings has gained significant attention recently, with applications ranging from serious games to clinical monitoring. With mobile users, however, challenges arise due to other overlapping (and potentially confounding) physiological responses (e.g., due to physical activity) that may mask the effects of stress, as well as movement artifacts that can be introduced in the measured signals. For example, the classical increase in heart rate can no longer be attributed solely to stress and could be caused by the activity itself. This makes the development of mobile passive B/BCIs challenging. In this paper, we introduce PASS, a multimodal database of Physical Activity and StresS collected from 48 participants. Participants performed tasks of varying stress levels at three different activity levels and provided quantitative ratings of their perceived stress and fatigue levels. To manipulate stress, two video games (i.e., a calm exploration game and a survival game) were used. Peripheral physical activity (electrocardiography, electrodermal activity, breathing, skin temperature) as well as cerebral activity (electroencephalography) were measured throughout the experiment. A complete description of the experimental protocol is provided and preliminary analyses are performed to investigate the physiological reactions to stress in the presence of physical activity. The PASS database, including raw data and subjective ratings has been made available to the research community at http://musaelab.ca/pass-database/. It is hoped that this database will help advance mobile passive B/BCIs for use in everyday settings.