1.
J Org Chem
; 81(7): 3023-30, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26959867
RESUMO
Highly enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles with α,ß-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).
2.
J Am Chem Soc
; 137(15): 4936-9, 2015 Apr 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25849154
RESUMO
A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed. The new strategy led to a series of optically active indolines bearing C2-quaternary stereocenters in modest to good yields with excellent enantioselectivities (up to 99% ee).