Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.

The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of ALM on hypertension-induced cardiac hypertrophy, as well as explore its underlying mechanisms. We evaluated the effects of ALM on spontaneously hypertensive rats and rat cardiomyocytes treated with Ang II. We found that ALM was not effective in lowering blood pressure in SHR, but it attenuated hypertension-mediated cardiac fibrosis, oxidative stress, inflammation, and hypertrophy in rats. After that, in cultured H9C2 cells stimulated with Ang II, ALM increased the expression of antioxidant proteins that were decreased in the Ang II group. ALM also alleviated cell hypertrophy and the accumulation of ROS, while LY294002 partially abrogated these effects. Collectively, these results demonstrate that ALM could alleviate oxidative stress in cardiac hypertrophy, potentially through the activation of the PI3K/Akt-mediated Nrf2 signaling pathway.

Farmers' adoption and perceived benefits of diversified crop rotations in the margins of U.S. Corn Belt.

Monoculture and simplified two-crop rotation systems compromise the ecosystem services essential to crop production, diminish agricultural productivity, and cause detrimental effects on the environment. In contrast to the simplified two-crop rotation, diversified crop rotation (DCR) refers to rotation systems that contain three or more crops. Despite multiple benefits generated by DCR, its usage has dwindled over the past several decades. This paper examined determinants of farmers' adoption decisions and perceived benefits of DCR in the west margins of the U.S. Corn Belt where crop diversity has declined. We analyzed 708 farmer responses from a farmer survey conducted in the eastern South Dakota in 2018, accounting for county-level climate variables, as well as cropland data, soil and topographic variables in close proximity of the farm. Our findings indicated that farmers were more likely to utilize DCR as an adaptive strategy to cope with water deficit and reduce soil erosion on marginal land. Additionally, livestock integration and organic farming helped necessitate DCR adoption and magnify its benefits. Producer concerns towards lack of equipment and new crop profitability diluted producers' interests in DCR practice and compromised its benefits. Enhanced technical and policy support, along with infrastructure and market development, could help producers fully utilize DCR benefits and expand DCR usage to more regions.

Willingness to Pay for Enhanced Mandatory Labelling of Genetically Modified Soybean Oil: Evidence from a Choice Experiment in China.

This study investigates consumers' preferences for mandatory labelling conveying the health and safety attributes of genetically modified soybean oil. The enhanced mandatory labelling includes allergen presence labelling, nutrient and compositional change labelling and traceability codes. The data were collected from a consumer survey in the eastern, central and western regions of China, with a total sample size of 804 respondents. We evaluated consumer willingness to pay (WTP) for enhanced mandatory labelling using a choice experiment approach. The results show that Chinese consumers are most favorable to traceability codes with a WTP of RMB 8.92, followed by allergen presences labelling, with RMB 6.57. Eastern consumers would like to pay a higher premium for the three types of enhanced mandatory labelling information, while central consumers only show a positive preference for traceability codes. The results imply that the efforts and policy strategies for enhanced mandatory labelling will benefit residents. Further studies can be expended to other genetically modified (GM) foods. This study provides information for the agency to improve mandatory GM food labelling management. This paper contributes to the growing body of the GM food literature by explicitly investigating consumer preference and WTP for mandatory labelling conveying the health and safety attributes of the GM foods.

Does the New Rural Pension Scheme improve residents' livelihoods? Empirical evidence from Northwestern China.

The sustainable development of pension systems has been investigated from a financial perspective worldwide. However, the pension adequacy and its effect on the sustainability of a national pension system are still understudied. Using actual replacement rate and modified living standards replacement rate, this study empirically evaluates whether China's New Rural Pension Scheme (NRPS) grants enough livelihood protection for the rural residents in the Northwestern China. The results show that the NRPS fails to meet the basic needs of the elderly people (i.e., age of sixty years or older) or the middle-aged people (forty-five to fifty-nine years old), while it only provides limited protection for the young people (sixteen to forty-four years old). These findings suggest that the current NRPS benefits are very low in the Northwestern China and policy reforms should be further implemented to improve the sustainable development of the New Rural Pension Scheme.

Consumer perception, mandatory labeling, and traceability of GM soybean oil: evidence from Chinese urban consumers.

Consumer preference for the mandatory labeling of genetically modified (GM) foods promotes public support for the implementation of GM food policies. This study analyzes consumers' preference for the traceability of GM soybean oil. Survey data were collected through a self-administered survey covering 804 randomly sampled urban residents in the eastern, central and western regions of China. Using a logit model, this analysis examines the impacts of influential factors on consumers' preference for traceability. The results show that about 56.5% of the respondents have a positive preference for the traceability of GM soybean oil. Factors increasing the preference for traceability include a better perception of the attributes of nutrition benefit and potential health risk, perceived inadequacy of simple mandatory labels, more attention paid to food labels, and distrust in the agencies overseeing GM food safety. Enhancing consumers' perceptions of GM-related attributes and awareness of food labels will help improve the mandatory labeling management of GM foods.

Consumer intention to purchase GM soybean oil in China: effects of information consistency and source credibility.

Consumers' potential reactions toward genetically modified (GM) foods affect their commercial feasibility and determine the decisions of economic agents. Inconsistent information on GM foods has created a sense of uncertainty in Chinese consumers' mind. This paper studies how the information about risks and benefits of GM foods from major sources influences Chinese consumer intention to purchase GM soybean oil. This analysis uses data from a survey of 880 residents randomly sampled from 13 cities in Jiangsu province. Using a multinomial logit model, we analyze the effects of information consistency and source credibility. The results show because of new information about 17.36% of consumers increase their intention to purchase GM soybean oil, and 15.10% of consumers decrease purchase intention. Compared to consistent information, inconsistent information can maximize change of purchase intention. The attitude change is greatest when there is a moderate difference between the new information and the initial consumer attitude. Furthermore, trust in biotechnology research institutes, government departments about GM, and GM experts are easier to promote consumers to change their intention to purchase GM soybean oil in a positive direction. Finally, we discuss implications for agencies as to strengthening the regulation and supervision of information sources, and including public-involved policies.Abbreviations: GM, Genetically modified; GMOs, Genetically modified organisms; AGGMO, Center of Agriculture's Genetically Modified Organisms' safety management and policy research organization at Nanjing Agricultural University; MARA, Ministry of Agriculture and Rural Affairs; ¥1 (RMB)≈$6.8 (USD).

Modification of Susceptible and Toxic Herbs on Grassland Disease.

Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to fungal diseases and increases in prevalence during over grazing due its toxicity to livestock. This study aimed to examine the effects of A. inebrians on biological control organisms and levels of plant diseases in overgrazed grasslands in northwestern China. The results showed that A. inebrians plants were seriously infected by fungal diseases and that this led to a high incidence of the mycoparasitic species Ampelomyces quisqualis and Sphaerellopsis filum. In addition, the fungivore, Aleocharinae, was found only in the soil growing A. inebrians rather than in the overgrazed area without A. inebrians. Overall, in an overgrazed grassland fenced for one year, disease levels in blocks without A. inebrians were significantly higher than those in blocks with A. inebrians. Our findings indicated that the disease susceptible, toxic A. inebrians can help control plant disease levels in overgrazed grasslands.

Fabrication of ordered lamellar polyacrylamide/P123 composite membranes via solvent-evaporation-induced self-assembly.

A series of composite membranes of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (P123) and polyacrylamide (PAM) have been successfully prepared by solvent-evaporation-induced self-assembly. Micellar self-assembly of P123 in aqueous solution plays an important role as a model for the formation of composite membranes. XRD patterns show that the synthesized compositions are in a lamellar mesostructure. The lattice spacing changes with P123 concentration: the higher the concentration of P123, the smaller the lattice spacing of the composite membranes. The data on sizes and zeta potentials of pure p-PAM aggregates, P123 micelles, p-PAM/P123 mixtures, and c-PAM/P123 composite aggregates suggest that interactions take place between PAM and P123 aggregations. The fabrication of the lamellar membranes via water-evaporation-induced self-assembly is recorded by fluorescent emission spectroscopy and dynamic light-scattering methods. Based on analysis of the results, a tentative mechanism for the formation of the lamellar membranes has been proposed.