1.
Org Lett
; 14(7): 1830-3, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22455465
RESUMO
A simple and efficient FeCl(3)-promoted cyclization/chlorination of cyclic tosylamine-tethered 8-aryl-2-en-7-yn-1-ols was observed. The reaction proceeded instantaneously at 23 °C in air to afford (Z)-4-(arylchloromethylene)-substituted azaspirocycles in good to excellent yields. This transformation can also be applied to the synthesis of spirocarbocyclic analogues from cyclic 8-aryl-2-en-7-yn-1-ols and FeCl(3).