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Molecules ; 29(15)2024 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-39125107

RESUMO

Photothermal, photodynamic and sonodynamic cancer therapies offer opportunities for precise tumor ablation and reduce side effects. The cyclic guanylate adenylate synthase-stimulator of interferon genes (cGAS-STING) pathway has been considered a potential target to stimulate the immune system in patients and achieve a sustained immune response. Combining photothermal, photodynamic and sonodynamic therapies with cGAS-STING agonists represents a newly developed cancer treatment demonstrating noticeable innovation in its impact on the immune system. Recent reviews have concentrated on diverse materials and their function in cancer therapy. In this review, we focus on the molecular mechanism of photothermal, photodynamic and sonodynamic cancer therapies and the connected role of cGAS-STING agonists in treating cancer.


Assuntos
Proteínas de Membrana , Neoplasias , Nucleotidiltransferases , Fotoquimioterapia , Humanos , Neoplasias/terapia , Neoplasias/tratamento farmacológico , Neoplasias/metabolismo , Nucleotidiltransferases/metabolismo , Proteínas de Membrana/metabolismo , Fotoquimioterapia/métodos , Transdução de Sinais/efeitos dos fármacos , Animais , Terapia por Ultrassom/métodos , Fármacos Fotossensibilizantes/farmacologia , Fármacos Fotossensibilizantes/uso terapêutico , Fármacos Fotossensibilizantes/química
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