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1.
Chinese Journal of School Health ; (12): 1021-1023, 2019.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-818642

RESUMO

Objective@#To investigate the status of eating disorders among overweight and obese adolescents as well as provide the basis for developing obesity precautionary and eating disorders.@*Methods@#910 adolescents of grade 4 to 6 in primary schools and grade 1 to 3 in junior middle schools were recruited in Bengbu by cluster random sampling to examine the association between obesity and eating disorders.@*Results@#A total of 203 children (22.3%) were overweight and obese, 547 children (60.1%) were normal weight and 160 children (17.6%) were low weight. The prevalence of overweight and obese in boys were significantly higher than those in girls (30.6% vs. 13.0%; χ2=40.55, P<0.01). Compared with normal weight group and low weight group, the scores of drive for thinness (DT), body dissatisfaction (BD), low self-esteem (LSE) and eating disorder risk composite (EDRC) were significantly higher in overweight and obese group (P<0.05). There was a positive association between the scores of DT(r=0.19), BD(r=0.30), LSE(r=0.09), interceptive deficits (ID) (r=0.08) and EDRC (rs=0.11) with body mass index (BMI)(P<0.05).@*Conclusion@#Eating disorders were associated with overweight and obesity of adolescents. A targeted strategies and measures should be conducted.

2.
Chinese Journal of Neuromedicine ; (12): 1045-1047, 2010.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-1033116

RESUMO

Objective To identify the ABCD1 gene mutation in a patient suspected with adrenoleukodystrophy (ALD) and perform its gene analysis in his family members to make a definite diagnosis. Methods Total RNA and genomic DNA were extracted from the leukocytes of peripheral blood in the proband and the family members. The ABCD1 coding region of cDNA in the proband was amplified and sequenced. Mutational site in the ABCD1 gene of the proband was further confirmed by PGR and direct sequencing; at the same time, the mutation in the ABCD1 gene of the genomic DNA in the family members was analyzed by direct sequencing. Results Two bases deletions (656_657delGA)were identified and the corresponding mutation of fs R89 was detected in the ABCD1 gene of the proband, which could make the definite diagnosis of ALD that belonged to adrenomyeloneuropathy. The same gene mutation (ALD hemizygote) was noted in his cousin; his mother, younger sister of his mother and his younger female cousin were noted as the ALD carrers. His older sister was noted as ABCD1 normal genotype. Conclusions A novel ABCD1 gene mutation (fs R89) was identified in Chinese patient with ALD. Molecular testing is an effective way in making diagnosis on patient suspected as having X-linked ALD.

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