Extramammary Paget's disease of scrotum. A case with local lymph node metastasis.

OBJECTIVE: We describe the clinical, histological and immunohistochemical studies in a case of extramammary Paget's disease localized in the scrotum with lymph node inguinal metastasis. METHODS/RESULTS: A 80-year old man consulted with a one-year history of a pruritic erythematous skin rash of the scrotum. Physical examination showed demarcated erythematous lesion involving the scrotum and right inguinal adenopathy. Final histological examination revealed extramammary Paget's disease with inguinal metastasis. CONCLUSION: Extramammary Paget's disease of the scrotum is a rare disease. This pathological condition may spread to dermal region and the regional lymph nodes. Although genitourinary cancer may accompany scrotal extramammary Paget's disease, an extensive search for cancer may be unnecessary.

[Primary urothelial carcinoma of the bulbomembranous urethra. Histologic and immunohistochemical study of a case]. / Carcinoma urotelial primario de uretra bulbomembranosa. Estudio histológico e inmunohistoquímico de un caso.

OBJECTIVE: We report a case of a primary urothelial carcinoma of the bulbomembranous urethra, with special emphasis on histopathological and immunohistochemical findings. METHODS/RESULTS: A 63-year-old man presented urethral obstruction symptoms. A radical phalectomy was performed and a 4.5 x 4 cm bulbomembranous urethral tumor was observed. Histopathological analysis disclosed an urothelial carcinoma, that showed positive immunostaining for cytokeratin AE1/AE3, cytokeratin 7, carcinoembrionic antigen and epithelial membrane antigen. The patient received radiotherapy and adjuvant chemotherapy and is currently free of disease. CONCLUSION: Posterior male urothelial carcinoma of the urethra is a rare neoplasm that usually is mistaken clinically for a benign lesion. The diagnostic is generally made in advanced stages with a poor therapeutical response.