RESUMO
The effect of glutathione S-transferase variants on pediatric busulfan metabolism was investigated by noncompartmental and population pharmacokinetic modeling. Twenty-nine children who underwent related or unrelated bone marrow or umbilical cord blood hematopoietic cell transplant were retrospectively studied. GSTA1, GSTP1, and GSTM1 variants were explored for their effects on busulfan exposures. Noncompartmental pharmacokinetic analyses showed that carriers of GSTA1*B had a 2.6-fold higher busulfan area under the curve and concentration at steady state compared with noncarriers (P Assuntos
Bussulfano/farmacocinética
, Variação Genética
, Glutationa Transferase/metabolismo
, Transplante de Células-Tronco Hematopoéticas
, Agonistas Mieloablativos/farmacocinética
, Adolescente
, Fatores Etários
, Peso Corporal
, Bussulfano/administração & dosagem
, Criança
, Pré-Escolar
, Simulação por Computador
, Feminino
, Genótipo
, Glutationa S-Transferase pi/metabolismo
, Glutationa Transferase/genética
, Humanos
, Lactente
, Infusões Intravenosas
, Masculino
, Modelos Biológicos
, Método de Monte Carlo
, Agonistas Mieloablativos/administração & dosagem
, Fenótipo
, Estudos Retrospectivos
, Adulto Jovem
