1.
Molecules
; 16(4): 3380-90, 2011 Apr 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21512446
RESUMO
A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected ßaminoalcohol by potassium permanganate.