RESUMO
The Mini-Mental State Examination and the WAIS-R were administered to 105 patients in the early stages of Alzheimer's disease. MMSE scores correlated 0.83 with full scale IQ, which indicates that the MMSE may be a reasonable alternative measure of overall intellectual functioning in Alzheimer patients, for whom more extensive testing is impractical or clinically inappropriate. The prediction formula is presented, along with a prediction table. Folstein and McHugh report that, as the WAIS Performance IQ falls below 100 in demented patients, that there is a concomitant decline in the MMSE below 24 points. Data from our laboratory further support what some clinicians have long suggested, ie, that in those cases where only the mental status examination can be given, this short test can provide a reasonably valid and reliable prediction of the patient's IQ score.
Assuntos
Doença de Alzheimer , Cognição , Testes de Inteligência , Idoso , Doença de Alzheimer/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
An improved cutter is described for cutting membrane filters in half during the performance of sterility tests on drugs.
Assuntos
Filtração , Esterilização , Tecnologia Farmacêutica , Membranas ArtificiaisAssuntos
Liofilização/instrumentação , Água/análise , Animais , Umidade , Leite/microbiologia , Toxinas Biológicas , VacinasRESUMO
Avian leukosis virus (ALV)-free candidate primary and secondary seed lots were indistinguishable from corresponding ALV-contaminated lots with respect to (i) potency as measured by titration in newborn and weanling mice and in the MA-104 plaque system, (ii) degree of viscerotropism as measured by viremia in monkeys, (iii) neurotropism as determined by the monkey neurovirulence test, and (iv) potency as determined by antibody response in monkeys inoculated by the intracerebral route.
