[Degree of radiation pathomorphosis of a tumor and the results of combination treatment of breast cancer]. / Stepen' luchevogo patomorfoza opukholi i rezul'taty kombinirovannogo lecheniia raka molochnoi zhelezy.

The long-term results of the combined therapy of 284 patients with infiltrative forms of breast cancer were correlated with the manifestations of radiation pathomorphosis in a tumor after preoperative radiation therapy at a single dose of 4 Gy, summary dose of 20 Gy. Surgical intervention was performed in 59% of the patients in the first 3 days after irradiation, in 30% of the patients in 4-9 days, in 11% in 10-20 days. The degree of radiation pathomorphosis was evaluated by the signs of disturbance of the general structure of the tumorous tissue and the structure of some cancer cells. The most significant changes in tumors were recorded 10-20 days after the termination of radiation therapy. An increase in the interval between the termination of irradiation and operation up to 20 days did not influence the long-term results of the combined therapy of patients with breast cancer. No correlation between the degree of radiation pathomorphosis and long-term results of combined therapy was revealed, therefore the qualitative determination of the degree of injury of tissue and cellular elements of a tumor cannot serve as an adequate criterion of efficacy of mean fractional radiation exposure in performing operation in the first 9 days after its completion.

[Allergic heparin-induced infiltrates and skin necrosis caused by subcutaneous injections of heparin]. / Allergicheskie geparinovye infil'traty i nekrozy kozhi, vyzvannye podkozhnym primeneniem geparina.

Application of heparin in low doses to the treatment of 6 patients to prevent postoperative venous thromboembolic complications led to the development of an allergic heparin infiltrate (AHI). In three cases, the AHI eventuated in skin and subcutaneous fat necrosis, while in the remaining cases, underwent a reverse development. Apparently, the basis of the AHI is formed by the immediate type hypersensitivity developing in the area of repeated heparin injections. The AHI should be treated with glucocorticoids, antihistamine drugs, and antibiotics.