Assuntos
Aldeído Oxirredutases/genética , Anoftalmia/genética , Consanguinidade , Éxons/genética , Mutação de Sentido Incorreto/genética , Adulto , Anoftalmia/diagnóstico , Anoftalmia/fisiopatologia , Eletrorretinografia , Potenciais Evocados Visuais/fisiologia , Feminino , Genes Recessivos , Humanos , Linhagem , Penetrância , Retina/fisiopatologia , Tomografia de Coerência ÓpticaRESUMO
OBJECTIVE: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome. MATERIALS AND METHODS: Participants were randomly allocated to one of three groups of 40 subjects receiving either unmodified curcumin or its phospholipid complex or placebo. Lipid profile and plasma CETP were measured at the start and six weeks after initiation of the treatment. The normality of data distribution was assessed by Kolmogorov-Smirnov test. Wilcoxon test was used for comparing the data before and after the intervention. The percent changes of CETP and biochemical factors among the three groups were compared using Kruskal-Wallis test. RESULTS: Serum CETP levels were not significantly altered among patients receiving curcumin. CONCLUSION: Curcumin and its complex had no significant effect on serum CETP concentrations.
RESUMO
Metabolic syndrome is the aggregation of cardiovascular risk factors that increases the risk of type 2 diabetes and cardiovascular diseases. Family and twin studies, heritability spectrum for its components and different prevalence among ethnicities, have provided genetic susceptibility to the metabolic syndrome. The investigations of genetic base for the disorder have recognized numerous chromosomes, various DNA polymorphisms in candidate genes and many gene variants, that are associated with metabolic syndrome as an entity or its traits, which mostly are related to lipid metabolism. In addition, recent finding of the role of rare variants, epigenetic mechanisms, non-coding RNAs and evaluating the function of genes in molecular networks have improved our knowledge. However, a common genetic basis explaining the co-occurrence of its components has not been identified and more researches are essential.
