Neural activity in functional movement disorders after inpatient rehabilitation.

Functional movement disorders (FMD) are a common source of disability in neurology.While treatment of FMD can reduce motor severity and disability, the neural mechanisms implicated in such a response remain unclear. We aimed to investigate neural changes in patients with FMD after a one-week multidisciplinary motor retraining (MoRe) treatment program. Fourteen FMD patients completed an emotional Go/No-Go fMRI task before and after MoRe treatment. Standardized pre- and post-treatment videos were rated for motor severity by a blinded reviewer using the psychogenic movement disorder rating scale (PMDRS). PMDRS scores before and after treatment were used for whole-brain regression. PMDRS scores were significantly reduced after MoRe treatment. Worse severity prior to treatment was associated with greater primary motor cortex (M1) activation at baseline and a larger response to treatment. Globally, increased connectivity between bilateral amygdala and premotor regions was observed following treatment. Lower post-treatment PMDRS scores were associated with increased connectivity between amygdala and ventromedial prefrontal cortex, whereas higher post-treatment PMDRS scores (and poorer treatment response) were associated with increased connectivity between amygdala and M1. Motor retraining in FMD may reorganize activity and connectivity in emotion processing and motor planning networks, with shifts in amygdala connectivity from posterior to frontal/prefrontal regions.

Inhibitory control mediates a negative relationship between body mass index and intelligence: A neurocognitive investigation.

The structure and function of the human brain is closely related to cognitive processes of the mind and physiological processes of the body, suggesting that an intricate relationship exists between cognitive health, body health, and underlying neural architecture. In the current study, morphometric differences in cortical and subcortical gray matter regions, white matter integrity, and resting-state functional connectivity was assessed to determine what combinations of neural variables best explain an interconnected behavioral relationship between body mass index (BMI), general intelligence, and specific measures of executive function. Data for 82 subjects were obtained from the Nathan Kline Institute Rockland Sample. Behavioral results indicated a negative relationship between BMI and intelligence, which exhibited mediation by an inhibitory measure of executive function. Neural analyses further revealed generally contrasting associations of BMI, intelligence, and executive function with cortical morphometric regions important for inhibitory control and directed attention. Moreover, BMI related to morphometric alterations in components of a frontolimbic network, namely reduced thickness in the anterior cingulate cortex and ventromedial prefrontal cortex, whereas intelligence and inhibitory control primarily related to increased thickness and volume in parietal regions, as well as significantly increased across-network connectivity of visual and default mode resting-state networks. These results propose that medial prefrontal structure and interconnected frontolimbic and frontoparietal networks are important to consider in the relationship between BMI, intelligence, and executive function.