RESUMO
A new case of osteomesopyknosis, a rare autosomal dominant axial osteosclerosis is reported, with 4 affected members of the same family. Biochemical investigations, bone mineral content (BMC) measurement, 99mTc HMDP bone scan and microscopy of iliac crest bone and femoral head have been performed on 1 subject. A marked increase of BMC was found, without abnormality of biochemical data. Microscopy of bone showed an increase of trabecular thickness, and a low rate of bone turnover. No abnormality of mineralization was found on microradiographs.
Assuntos
Osso e Ossos/patologia , Genes Dominantes , Osteosclerose/patologia , Osso e Ossos/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Osteosclerose/diagnóstico por imagem , Osteosclerose/genética , Linhagem , RadiografiaAssuntos
Artrite Reumatoide/tratamento farmacológico , Tiopronina/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Interações Medicamentosas , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Penicilamina/efeitos adversos , Fatores de Tempo , Tiopronina/uso terapêuticoRESUMO
The authors compared, with the help of five radiological indices bearing on part (hand and wrists) or the all the articulations of the limbs concerned by rheumatoid arthritis (RA), a group of 45 RA with rheumatoid factor IgA (RF IgA) with a group of 45 RA without RF IgA by matching them according to age, sex and duration of evolution. They did not find any significant difference between the two groups for any of the indices. Although they are more often associated with agglutinant RF IgM, the RA with RF IgA are not more severe on the radiological level than the RA without FR IgA.
Assuntos
Artrite Reumatoide/sangue , Artrite Reumatoide/diagnóstico por imagem , Imunoglobulina A/metabolismo , Fator Reumatoide/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos RetrospectivosRESUMO
Forty-five consecutive primary Sjögren's syndrome (SS) patients were divided into two subgroups according to the presence (n = 30) of Raynaud's phenomenon (RP). Non-erosive arthritis was significantly more frequent in the patients with RP than in those without. RP was not associated with HLA-DR4 in primary SS patients.
Assuntos
Doença de Raynaud/complicações , Síndrome de Sjogren/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Artrite/complicações , Artrite Reumatoide/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Sjogren/fisiopatologiaRESUMO
The antiperinuclear factor (APF) test raises two main problems: the unpredictability of the cells used as substrate and the difficulty in expressing the results. We propose that 10% of the cells have to be stained by a given serum in order for it to be considered positive. APF were found to be present in 76% of rheumatoid arthritis (RA) patients, 3% of healthy controls and occasionally in disease controls. The production of APF was significantly (p less than 0.01) related to the presence of rheumatoid factor in RA, and IgG antibody was predominant in the APF test.
Assuntos
Anticorpos Antinucleares/análise , Anticorpos Antinucleares/imunologia , Artrite Reumatoide/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Autoanticorpos/análise , Bochecha , Estudos de Avaliação como Assunto , Feminino , Teste de Histocompatibilidade , Humanos , Imunoglobulina G/análise , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/análise , Coloração e RotulagemRESUMO
Fifteen patients with rheumatoid arthritis were treated with tiopronine, and an immunological check-up carried out before the onset and after a two-month treatment. The latex test titres decreased, and there was a significant fall in the levels of IgA-containing circulating immune complexes, in parallel with a depletion of plasma complement breakdown products. Patients displayed a decrease in CD8+T cells and in CD4+Leu 8-T cells and a high proportion of activated T lymphocytes. This returned to normal after treatment. Treatment with TP led also to a reduction of adherence and chemotaxis of polymorphonuclear cells.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Tiopronina/uso terapêutico , Adulto , Idoso , Artrite Reumatoide/imunologia , Autacoides/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neutrófilos/imunologia , Linfócitos T/imunologia , Tiopronina/farmacologiaRESUMO
The levels of serum C-reactive protein (CRP) were found to be significantly higher in the presence than in the absence of secondary Sjögren's syndrome in patients with rheumatoid arthritis, while the values of erythrocyte sedimentation rate and serum fibrinogen were not significantly different. The levels of CRP were found to be normal in 22 out of 24 patients with primary Sjögren's syndrome.
Assuntos
Artrite Reumatoide/sangue , Proteína C-Reativa/análise , Síndrome de Sjogren/sangue , Adulto , Idoso , Artrite Reumatoide/complicações , Sedimentação Sanguínea , Feminino , Fibrinogênio/análise , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Sjogren/classificação , Síndrome de Sjogren/etiologiaAssuntos
Infecções Bacterianas/complicações , Prótese Vascular/efeitos adversos , Osteoartropatia Hipertrófica Primária/etiologia , Osteoartropatia Hipertrófica Secundária/etiologia , Idoso , Antibacterianos/uso terapêutico , Infecções Bacterianas/tratamento farmacológico , Humanos , Masculino , Osteoartropatia Hipertrófica Secundária/tratamento farmacológicoAssuntos
Doença Hepática Induzida por Substâncias e Drogas/etiologia , Epirubicina/farmacocinética , Tamoxifeno/efeitos adversos , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/secundário , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/secundário , Neoplasias da Mama , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Osteoartrite do Quadril/diagnóstico por imagem , Policondrite Recidivante/diagnóstico por imagem , Adulto , Feminino , Prótese de Quadril , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/tratamento farmacológico , Osteoartrite do Quadril/patologia , Policondrite Recidivante/tratamento farmacológico , Policondrite Recidivante/patologia , Radiografia , Sulfanilamidas/uso terapêuticoAssuntos
Antígenos HLA-A/análise , Antígenos HLA-B/análise , Antígenos HLA-DR/análise , Hiperparatireoidismo/imunologia , Adenoma/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias das Paratireoides/complicaçõesAssuntos
Ligamentos , Policondrite Recidivante/complicações , Tendinopatia/etiologia , Tíbia , Adulto , Humanos , MasculinoRESUMO
Using a newly developed enzyme-linked immunosorbent assay, antibodies to histones (H1, H2A, H2B, H3 and H4) were found in 32 out of 40 rheumatoid arthritis patients with antinuclear antibodies at a titer greater than or equal to 100 as measured by indirect immunofluorescence. The anti-H2A reactivity was higher in patients with secondary Sjögren's syndrome than in those without, but the highest antihistone reactivity and the most heterogeneous patterns were observed in patients who were receiving D-penicillamine.
