[Suppressive effect of circulating immune complexes on cytotoxicity of blood lymphocytes in patients with chronic myeloid leukemia]. / Supressivnoe deistvie tsirkuliruiushchikh immunnykh kompleksov na tsitotoksichnost' limfotsitov krovi bol'nykh khronicheskim mielo- leikozom.

Concentration of circulating immune complexes (CIC) and cytotoxicity (natural and antibody-dependent) of blood lymphocytes were studied in 52 patients at the developed stage of chronic myeloid leukemia (CML). Elevation of CIC level and reduction of cytotoxicity detectable in all CML patients were most manifest in those with high tumor mass and during exacerbation of the leukemia process. A conclusion has been made that CIC are suppressors of natural and antibody-dependent cytotoxicity of blood lymphocytes in CML patients.

[The characteristics of the humoral interaction of lymphocytes with neutrophilic granulocytes of the peripheral blood in patients with chronic lympholeukemia under the influence of Proper-Myl]. / Osobennosti gumoral'nogo vzaimodeistviia limfotsitov s neitrofil'nymi granulotsitami perifericheskoi krovi u bol'nykh khronicheskim limfoleikozom pod vliianiem proper-mila.

A study of 32 patients with chronic lympholeucosis (CL) revealed a reduction of the number of phagocytosing neutrophil granulocytes and a reduction of production of humoral mediators by lymphocytes that stimulated the phagocytic function of granulocytes. It is shown that treatment by usually used cytostatic agents did not essentially effect the investigated values. Inclusion of proper-myl in the treatment course of patients with chronic lympholeucosis furthered increase of the number of phagocytosing neutrophil granulocytes and an increased production of humoral mediator stimulating the phagocytic activity of granulocytes.

[Interactions of peripheral blood lymphocytes and neutrophils in the stimulation of lymphokine production in chronic leukemia]. / Vzaimodeistvie limfotsitov i neitrofilov perifericheskoi krovi v stimuliatsii limfokinoobrazovaniia pri khronicheskikh leikozakh.

Inclusion of T-activin into the combined therapy of patients with chronic myelo- and lympholeukemia promotes intensified lymphokine production by peripheral blood lymphocytes. Lymphokine stimulates neutrophil phagocytic activity, therefore ++T-activin is recommended for prevention and treatment of infectious complications.

[NAD- and NADP-diaphorase activity in the peripheral blood lymphocytes of patients with the B-cell variant of chronic lympholeukemia]. / Aktivnost' NAD- i NADP-diaforaz v limfotsitakh perifericheskoi krovi bol'nykh B-kletochnym variantom khronicheskogo limfoleikoza.

The authors studied the cytotoxic function, activity of NAD- and NADP-diaphorases in the peripheral blood lymphocytes in 57 patients with B-cellular variant of chronic lympholeukoses and found a significant reduction of the natural killer activity of lymphocytes, increased activity of NADP-diaphorase. Reduction of natural killer activity in patients with B-cell variant of chronic lympholeukoses did not depend on the activity of membrane diaphorases in peripheral blood lymphocytes.

[The determination of the activity of natural killer cells in chronic lympholeukemia based on radiometric and morphological data]. / Opredelenie aktivnosti estestvennykh kletok-killerov pri khronicheskom limfoleikoze po dannym radiometricheskogo i morfologicheskogo metodov.

Function of lymphocytes as effector cells of natural cytotoxicity in chronic lympholeukemia was investigated using radiometric and morphological methods. The effectiveness of these methods was compared. A significant decrease in NKC activity in B-cell type of chronic lympholeukemia was detected. A high degree of positive correlation between radiometry and morphology findings was revealed. The radionuclide (51Cr) method of investigation of NKC activity of lymphocytes was shown to have more advantages over the alternative morphological method in terms of practicability, accuracy and objectiveness.