Assuntos
Testes para Micronúcleos/instrumentação , Lesões Experimentais por Radiação/genética , Lesões por Radiação/genética , Animais , Aberrações Cromossômicas , Relação Dose-Resposta à Radiação , Citometria de Fluxo , Humanos , Linfócitos/efeitos da radiação , Linfócitos/ultraestrutura , Testes para Micronúcleos/métodos , Lesões por Radiação/sangue , Lesões Experimentais por Radiação/sangueRESUMO
The chromosomal damage (micronuclei) of the peripheral blood lymphocytes of the group of professionals who had participated in the liquidation of the Chernobyl NPP accident and have continued their work at the "Shelter" and of the group of self-settlers who living for about ten year in the Chernobyl NPP alienation zone were studied. Residents of Kyïv were the group for comparison. It was found that in professionals the number of micronuclei was higher due to the presence of cells with several micronuclei while in the self-settlers it was due to the increase in the number of cells with one micronucleus. Also was determined the correlation between the frequency of micronuclei in the lymphocytes of the self-settlers on the one hand and the level of radionuclides contamination of territory and dose loading on the other.
Assuntos
Emigração e Imigração , Exposição Ambiental/efeitos adversos , Linfócitos/efeitos da radiação , Micronúcleos com Defeito Cromossômico/efeitos da radiação , Exposição Ocupacional/efeitos adversos , Centrais Elétricas , Liberação Nociva de Radioativos , Adulto , Aberrações Cromossômicas , Exposição Ambiental/estatística & dados numéricos , Feminino , Humanos , Masculino , Testes para Micronúcleos/estatística & dados numéricos , Pessoa de Meia-Idade , Exposição Ocupacional/estatística & dados numéricos , Doses de Radiação , UcrâniaRESUMO
Blast-transformation of lymphocytes of pregnant and control mice of three lines was studied after their in vitro stimulation with phytohemaglutinin. There was no significant difference between lymphocyte transformation in pregnant and control mice, and the blood sera of pregnant animals do not inhibit blast-transformation. The responsiveness of CBA strain lymphocytes was higher than that of BALB/C and C57BL strains.