[Pathomorphological changes in the pancreatic ductal system in fatty and hemorrhagic pancreonecrosis in experiment].

The pancreatic ductal system was morphologically studied in fatty and hemorrhagic pancreonecrosis in experiments. The latter were carried out on 105 male Wistar rats. The use of the study models of fatty (administration of phospholipase A2, common bile duct ligation, and their combination) and hemorrhagic pancreonecrosis (administration of trypsin and snake venom) has shown that in fatty pancreonecrosis there are changes initially revealed in the pancreatic ductal system with subsequent necrosis of its parenchyma. In hemorrhagic pancreonecrosis, the ductal system retains its structure. Based on the findings, the authors soundly identify two forms of acute pancreatitis: primary acinar (parenchymatous) and hypertensive ductal.